Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Morphine addiction 💬
1件: ADORA1 💬 D00045 💬 Adenosine 3件: 13, 58, 65 💬
2 Morphine addiction 💬
1件: ADORA1 💬 D02769 💬 Adenosine phosphate 1件: 46 💬
3 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00227 💬 Aminophylline 1件: 63 💬
4 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D05429 💬 Aminophylline 1件: 63 💬
5 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
6 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
7 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D02017 💬 Theophylline 2件: 236, 299 💬
8 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
9 Morphine addiction 💬
17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06104 💬 Theophylline 2件: 236, 299 💬
10 Morphine addiction 💬
9件: ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
11 Morphine addiction 💬
9件: ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
12 Morphine addiction 💬
1件: CACNA1B 💬 D01173 💬 Cilnidipine 1件: 67 💬
13 Morphine addiction 💬
1件: DRD1 💬 D02004 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
14 Morphine addiction 💬
1件: DRD1 💬 D07460 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
15 Morphine addiction 💬
1件: DRD1 💬 D09886 💬 Dexpramipexole 1件:  2  💬
16 Morphine addiction 💬
1件: DRD1 💬 D00633 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
17 Morphine addiction 💬
1件: DRD1 💬 D07870 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
18 Morphine addiction 💬
1件: DRD1 💬 D01044 💬 Flupentixol 1件: 97 💬
19 Morphine addiction 💬
1件: DRD1 💬 D11839 💬 Foslevodopa 1件:  6  💬
20 Morphine addiction 💬
1件: DRD1 💬 D00059 💬 Levodopa 8件:  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
21 Morphine addiction 💬
1件: DRD1 💬 D00502 💬 Pergolide 1件:  6  💬
22 Morphine addiction 💬
1件: DRD1 💬 D08339 💬 Pergolide 1件:  6  💬
23 Morphine addiction 💬
1件: DRD1 💬 D11431 💬 Tavapadon 1件:  6  💬
24 Morphine addiction 💬
2件: GABBR1, GABBR2 💬 D09791 💬 Arbaclofen 2件: 13, 206 💬
25 Morphine addiction 💬
2件: GABBR1, GABBR2 💬 D08861 💬 Arbaclofen Placarbil 1件: 13 💬
26 Morphine addiction 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 7件:  2 , 10, 13, 18, 65, 149, 206 💬
27 Morphine addiction 💬
1件: GABRA1 💬 D00548 💬 Etomidate 1件:  6  💬
28 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam 2件:  8 , 75 💬
29 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone 1件: 205 💬
30 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00267 💬 Chlordiazepoxide 1件: 46 💬
31 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00693 💬 Chlordiazepoxide 1件: 46 💬
32 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
33 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00280 💬 Clonazepam 1件:  6  💬
34 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D07784 💬 Delorazepam 3件:  6 , 46, 97 💬
35 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00293 💬 Diazepam 3件: 46, 155, 298 💬
36 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D02624 💬 Eszopiclone 3件:  6 , 13, 46 💬
37 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01514 💬 Etizolam 1件: 46 💬
38 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
39 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04282 💬 Gaboxadol 2件: 201, 206 💬
40 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone 4件: 145, 152, 158, 206 💬
41 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00365 💬 Lorazepam 2件: 36, 231 💬
42 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00550 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
43 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00696 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
44 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D05028 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
45 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 10件:  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
46 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
47 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00706 💬 Zolpidem 3件:  5 ,  6 , 46 💬
48 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D08690 💬 Zolpidem 3件:  5 ,  6 , 46 💬
49 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01372 💬 Zopiclone 1件:  6  💬
50 Morphine addiction 💬
2件: KCNJ3, KCNJ5 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
51 Morphine addiction 💬
2件: KCNJ3, KCNJ5 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
52 Morphine addiction 💬
1件: OPRM1 💬 D00836 💬 Buprenorphine 3件: 46, 70, 298 💬
53 Morphine addiction 💬
1件: OPRM1 💬 D07132 💬 Buprenorphine 3件: 46, 70, 298 💬
54 Morphine addiction 💬
1件: OPRM1 💬 D01481 💬 Dihydrocodeine 1件: 310 💬
55 Morphine addiction 💬
1件: OPRM1 💬 D07831 💬 Dihydrocodeine 1件: 310 💬
56 Morphine addiction 💬
1件: OPRM1 💬 D00320 💬 Fentanyl 4件: 46, 70, 215, 231 💬
57 Morphine addiction 💬
1件: OPRM1 💬 D01399 💬 Fentanyl 4件: 46, 70, 215, 231 💬
58 Morphine addiction 💬
1件: OPRM1 💬 D00839 💬 Hydromorphone 1件: 70 💬
59 Morphine addiction 💬
1件: OPRM1 💬 D08047 💬 Hydromorphone 1件: 70 💬
60 Morphine addiction 💬
1件: OPRM1 💬 D00729 💬 Loperamide 2件: 13, 97 💬
61 Morphine addiction 💬
1件: OPRM1 💬 D07113 💬 Loperamide 2件: 13, 97 💬
62 Morphine addiction 💬
1件: OPRM1 💬 D08144 💬 Loperamide 2件: 13, 97 💬
63 Morphine addiction 💬
1件: OPRM1 💬 D01383 💬 Meperidine 1件: 298 💬
64 Morphine addiction 💬
1件: OPRM1 💬 D08343 💬 Meperidine 1件: 298 💬
65 Morphine addiction 💬
1件: OPRM1 💬 D00842 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
66 Morphine addiction 💬
1件: OPRM1 💬 D02271 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
67 Morphine addiction 💬
1件: OPRM1 💬 D08233 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
68 Morphine addiction 💬
1件: OPRM1 💬 D00843 💬 Nalbuphine 1件: 85 💬
69 Morphine addiction 💬
1件: OPRM1 💬 D08246 💬 Nalbuphine 1件: 85 💬
70 Morphine addiction 💬
1件: OPRM1 💬 D05111 💬 Nalmefene 1件:  6  💬
71 Morphine addiction 💬
1件: OPRM1 💬 D01340 💬 Naloxone 2件:  6 , 226 💬
72 Morphine addiction 💬
1件: OPRM1 💬 D08249 💬 Naloxone 2件:  6 , 226 💬
73 Morphine addiction 💬
1件: OPRM1 💬 D02095 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
74 Morphine addiction 💬
1件: OPRM1 💬 D05113 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
75 Morphine addiction 💬
1件: OPRM1 💬 D03783 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
76 Morphine addiction 💬
1件: OPRM1 💬 D05312 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
77 Morphine addiction 💬
1件: OPRM1 💬 D05462 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
78 Morphine addiction 💬
1件: OPRM1 💬 D08323 💬 Oxymorphone 1件: 70 💬
79 Morphine addiction 💬
1件: OPRM1 💬 D01177 💬 Remifentanil 2件:  6 , 70 💬
80 Morphine addiction 💬
1件: OPRM1 💬 D08473 💬 Remifentanil 2件:  6 , 70 💬
81 Morphine addiction 💬
1件: OPRM1 💬 D00845 💬 Sufentanil 2件: 70, 280 💬
82 Morphine addiction 💬
1件: OPRM1 💬 D05938 💬 Sufentanil 2件: 70, 280 💬
83 Morphine addiction 💬
1件: OPRM1 💬 D01355 💬 Tramadol 5件: 46, 70, 78, 226, 271 💬
84 Morphine addiction 💬
1件: OPRM1 💬 D08623 💬 Tramadol 5件: 46, 70, 78, 226, 271 💬
85 Morphine addiction 💬
1件: OPRM1 💬 D08639 💬 Trimebutine 1件: 51 💬
86 Morphine addiction 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07546 💬 Bucladesine 1件: 246 💬
87 Morphine addiction 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00718 💬 Flavoxate 1件: 226 💬
88 Morphine addiction 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07961 💬 Flavoxate 1件: 226 💬
89 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 D01896 💬 Cilostazol 3件: 51, 70, 124 💬
90 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 D04720 💬 Levosimendan 1件:  2  💬
91 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 D00417 💬 Milrinone 1件: 294 💬
92 Morphine addiction 💬
2件: PDE3A, PDE3B 💬 D02085 💬 Milrinone 1件: 294 💬
93 Morphine addiction 💬
6件: PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D01385 💬 Ibudilast 2件:  2 , 13 💬
94 Morphine addiction 💬
1件: PDE4A 💬 D00302 💬 Dipyridamole 6件: 46, 49, 51, 66, 96, 224 💬
95 Morphine addiction 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D08860 💬 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271 💬
96 Morphine addiction 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D05744 💬 Roflumilast 2件: 84, 299 💬
97 Morphine addiction 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D01783 💬 Rolipram 2件:  8 , 13 💬