Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Caffeine 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
2 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Caffeine hydrate 💬 Caffeine 8件:  2 ,  6 , 21, 46, 78, 96, 97, 265 💬
3 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Istradefylline 💬 Istradefylline 1件:  6  💬
4 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Preladenant 💬 Preladenant 1件:  6  💬
5 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Regadenoson 💬 Regadenoson 1件: 58 💬
6 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Regadenoson 💬 Regadenoson 1件: 58 💬
7 Rap1 signaling pathway 💬
1件: ADORA2A 💬 Tozadenant 💬 Tozadenant 1件:  6  💬
8 Rap1 signaling pathway 💬
2件: ADORA2A, ADORA2B 💬 Adenosine 💬 Adenosine 3件: 13, 58, 65 💬
9 Rap1 signaling pathway 💬
2件: ADORA2A, ADORA2B 💬 Adenosine phosphate 💬 Adenosine phosphate 1件: 46 💬
10 Rap1 signaling pathway 💬
1件: ADORA2B 💬 Aminophylline 💬 Aminophylline 1件: 63 💬
11 Rap1 signaling pathway 💬
1件: ADORA2B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
12 Rap1 signaling pathway 💬
1件: ADORA2B 💬 Theophylline 💬 Theophylline 2件: 236, 299 💬
13 Rap1 signaling pathway 💬
1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬
14 Rap1 signaling pathway 💬
6件: BRAF, FLT4, KDR, KIT, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬
15 Rap1 signaling pathway 💬
1件: CNR1 💬 Cannabidiol 💬 Cannabidiol 20件:  2 ,  6 ,  8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
16 Rap1 signaling pathway 💬
1件: CNR1 💬 Dronabinol 💬 Dronabinol 8件:  2 ,  8 , 13, 36, 46, 96, 271, 298 💬
17 Rap1 signaling pathway 💬
1件: CNR1 💬 Nabilone 💬 Nabilone 3件:  6 , 13, 127 💬
18 Rap1 signaling pathway 💬
1件: CNR1 💬 Rimonabant 💬 Rimonabant 1件: 193 💬
19 Rap1 signaling pathway 💬
7件: CSF1R, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬
20 Rap1 signaling pathway 💬
2件: CSF1R, KIT 💬 Pexidartinib 💬 Pexidartinib 1件: 34 💬
21 Rap1 signaling pathway 💬
1件: DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬
22 Rap1 signaling pathway 💬
1件: DRD2 💬 Aripiprazole 💬 Aripiprazole 2件:  6 , 206 💬
23 Rap1 signaling pathway 💬
1件: DRD2 💬 Bromocriptine 💬 Bromocriptine 2件:  6 , 74 💬
24 Rap1 signaling pathway 💬
1件: DRD2 💬 Buspirone 💬 Buspirone 2件:  6 , 51 💬
25 Rap1 signaling pathway 💬
1件: DRD2 💬 Cabergoline 💬 Cabergoline 3件:  6 , 74, 75 💬
26 Rap1 signaling pathway 💬
1件: DRD2 💬 Cariprazine 💬 Cariprazine 1件: 21 💬
27 Rap1 signaling pathway 💬
1件: DRD2 💬 Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
28 Rap1 signaling pathway 💬
1件: DRD2 💬 Dexpramipexole 💬 Dexpramipexole 1件:  2  💬
29 Rap1 signaling pathway 💬
1件: DRD2 💬 Domperidone 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
30 Rap1 signaling pathway 💬
1件: DRD2 💬 Domperidone maleate 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬
31 Rap1 signaling pathway 💬
1件: DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬
32 Rap1 signaling pathway 💬
1件: DRD2 💬 Flupentixol 💬 Flupentixol 1件: 97 💬
33 Rap1 signaling pathway 💬
1件: DRD2 💬 Foslevodopa 💬 Foslevodopa 1件:  6  💬
34 Rap1 signaling pathway 💬
1件: DRD2 💬 Haloperidol 💬 Haloperidol 1件:  8  💬
35 Rap1 signaling pathway 💬
1件: DRD2 💬 Iloperidone 💬 Iloperidone 1件:  6  💬
36 Rap1 signaling pathway 💬
1件: DRD2 💬 Levodopa 💬 Levodopa 6件:  6 , 17, 90, 140, 164, 201 💬
37 Rap1 signaling pathway 💬
1件: DRD2 💬 Lisuride 💬 Lisuride 2件:  6 , 86 💬
38 Rap1 signaling pathway 💬
1件: DRD2 💬 Melperone 💬 Melperone 1件:  6  💬
39 Rap1 signaling pathway 💬
1件: DRD2 💬 Metoclopramide 💬 Metoclopramide 2件: 46, 51 💬
40 Rap1 signaling pathway 💬
1件: DRD2 💬 Olanzapine 💬 Olanzapine 2件:  2 ,  8  💬
41 Rap1 signaling pathway 💬
1件: DRD2 💬 Pardoprunox 💬 Pardoprunox 1件:  6  💬
42 Rap1 signaling pathway 💬
1件: DRD2 💬 Pergolide 💬 Pergolide 1件:  6  💬
43 Rap1 signaling pathway 💬
1件: DRD2 💬 Pimozide 💬 Pimozide 1件:  2  💬
44 Rap1 signaling pathway 💬
1件: DRD2 💬 Piribedil 💬 Piribedil 1件:  6  💬
45 Rap1 signaling pathway 💬
1件: DRD2 💬 Pramipexole 💬 Pramipexole 3件:  2 ,  6 , 20 💬
46 Rap1 signaling pathway 💬
1件: DRD2 💬 Pridopidine 💬 Pridopidine 3件:  2 ,  6 ,  8  💬
47 Rap1 signaling pathway 💬
1件: DRD2 💬 Quetiapine 💬 Quetiapine 2件:  6 , 13 💬
48 Rap1 signaling pathway 💬
1件: DRD2 💬 Risperidone 💬 Risperidone 5件:  8 , 156, 179, 187, 206 💬
49 Rap1 signaling pathway 💬
1件: DRD2 💬 Ropinirole 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬
50 Rap1 signaling pathway 💬
1件: DRD2 💬 Rotigotine 💬 Rotigotine 1件:  6  💬
51 Rap1 signaling pathway 💬
1件: DRD2 💬 Sulpiride 💬 Sulpiride 2件:  6 , 70 💬
52 Rap1 signaling pathway 💬
1件: DRD2 💬 Terguride 💬 Terguride 2件: 51, 86 💬
53 Rap1 signaling pathway 💬
1件: DRD2 💬 Tiapride 💬 Tiapride 1件:  8  💬
54 Rap1 signaling pathway 💬
1件: DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine 2件: 283, 284 💬
55 Rap1 signaling pathway 💬
1件: DRD2 💬 Trifluoperazine 💬 Trifluoperazine 2件: 283, 284 💬
56 Rap1 signaling pathway 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 2件: 51, 86 💬
57 Rap1 signaling pathway 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 1件: 94 💬
58 Rap1 signaling pathway 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬
59 Rap1 signaling pathway 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬
60 Rap1 signaling pathway 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
61 Rap1 signaling pathway 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬
62 Rap1 signaling pathway 💬
3件: EGFR, FLT4, KDR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬
63 Rap1 signaling pathway 💬
4件: EPHA2, KIT, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
64 Rap1 signaling pathway 💬
4件: EPHA2, KIT, PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬
65 Rap1 signaling pathway 💬
1件: FGF23 💬 Burosumab 💬 Burosumab 1件: 238 💬
66 Rap1 signaling pathway 💬
3件: FGFR1, FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib 1件: 276 💬
67 Rap1 signaling pathway 💬
8件: FGFR1, FGFR2, FGFR3, FLT1, FLT4, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬
68 Rap1 signaling pathway 💬
1件: FGFR2 💬 Palifermin 💬 Palifermin 5件: 13, 36, 38, 39, 65 💬
69 Rap1 signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 Axitinib 💬 Axitinib 1件: 34 💬
70 Rap1 signaling pathway 💬
3件: FLT1, FLT4, KDR 💬 Cediranib 💬 Cediranib 1件: 34 💬
71 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Acamprosate 💬 Acamprosate 2件:  6 , 206 💬
72 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Amantadine 💬 Amantadine 4件:  6 ,  8 , 13, 127 💬
73 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Dextromethorphan 💬 Dextromethorphan 11件:  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
74 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Esketamine 💬 Esketamine 3件:  2 ,  4 , 70 💬
75 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Ketamine 💬 Ketamine 8件:  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
76 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Latrepirdine 💬 Latrepirdine 1件:  8  💬
77 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Memantine 💬 Memantine 8件:  2 ,  6 ,  8 , 13, 49, 127, 205, 206 💬
78 Rap1 signaling pathway 💬
3件: GRIN1, GRIN2A, GRIN2B 💬 Riluzole 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
79 Rap1 signaling pathway 💬
1件: IGF1R 💬 Linsitinib 💬 Linsitinib 1件: 232 💬
80 Rap1 signaling pathway 💬
1件: IGF1R 💬 Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
81 Rap1 signaling pathway 💬
1件: IGF1R 💬 Teprotumumab 💬 Teprotumumab 1件: 51 💬
82 Rap1 signaling pathway 💬
1件: INSR 💬 Insulin detemir 💬 Insulin detemir 1件: 299 💬
83 Rap1 signaling pathway 💬
1件: INSR 💬 Insulin glargine 💬 Insulin glargine 1件: 299 💬
84 Rap1 signaling pathway 💬
1件: INSR 💬 Insulin human 💬 Insulin human 2件: 96, 156 💬
85 Rap1 signaling pathway 💬
1件: ITGAL 💬 Efalizumab 💬 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
86 Rap1 signaling pathway 💬
2件: KDR, MET 💬 Cabozantinib 💬 Cabozantinib 1件: 34 💬
87 Rap1 signaling pathway 💬
1件: KIT 💬 Masitinib 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
88 Rap1 signaling pathway 💬
2件: KIT, PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
89 Rap1 signaling pathway 💬
3件: KIT, PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
90 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬
91 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬
92 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬
93 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬
94 Rap1 signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬
95 Rap1 signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Losmapimod 💬 Losmapimod 2件: 113, 222 💬
96 Rap1 signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 Neflamapimod 💬 Neflamapimod 1件:  8  💬
97 Rap1 signaling pathway 💬
1件: NGF 💬 Tanezumab 💬 Tanezumab 2件: 226, 298 💬
98 Rap1 signaling pathway 💬
1件: NGFR 💬 Cenegermin 💬 Cenegermin 2件: 53, 90 💬
99 Rap1 signaling pathway 💬
3件: PGF, VEGFA, VEGFB 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬
100 Rap1 signaling pathway 💬
1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬
101 Rap1 signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬
102 Rap1 signaling pathway 💬
1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬
103 Rap1 signaling pathway 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬
104 Rap1 signaling pathway 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬
105 Rap1 signaling pathway 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬
106 Rap1 signaling pathway 💬
1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬
107 Rap1 signaling pathway 💬
1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬