:Methionine    (DrugBank: Methionine)

7 diseases
告示番号疾患名(ページ内リンク)臨床試験数
34神経線維腫症1
75クッシング病1
84サルコイドーシス2
93原発性胆汁性胆管炎2
229肺胞蛋白症(自己免疫性又は先天性)1
298遺伝性膵炎1
300IgG4関連疾患1

34. 神経線維腫症 [臨床試験数:120,薬物数:182(DrugBank:72),標的遺伝子数:84,標的パスウェイ数:194
Searched query = "Neurofibromatosis", "NF1", "von Recklinghausen disease", "NF2"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 120 trial found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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1EUCTR2010-019759-23-GB12/01/201113/12/2010Evaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PETEvaluation of [11C]-methionine positron emission computerised tomography (PET CT) in diagnosing neurofibromatosis 1(NF1) - malignant peripheral nerve sheath tumours (MPNST) - Methionine PET The diagnosis of malignant peripheral nerve sheath tumours in patients with neurofibromatosis 1
MedDRA version: 12Level: LLTClassification code 10029268Term: Neurofibromatosis 1 associated malignant peripheral nerve sheath tumour
Product Name: [11C]-methionine
INN or Proposed INN: 2-amino-4-(methyl[11C]sulfanyl)butanoic acid
Other descriptive name: Methionine
Guys' and St. Thomas' NHS Foundation TrustNULLNot RecruitingFemale: yes
Male: yes
United Kingdom

75. クッシング病 [臨床試験数:191,薬物数:172(DrugBank:48),標的遺伝子数:61,標的パスウェイ数:121
Searched query = "Cushing disease", "Cushing"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 191 trial found
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Public_titleScientific_titleConditionInterventionPrimary_
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1NCT03346954December 11, 201715/11/2017Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's DiseaseImpact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's DiseaseCushing's DiseaseOther: [11C]-Methionine PET/MRIHospices Civils de LyonNULLCompleted18 YearsN/AAll33N/AFrance

84. サルコイドーシス [臨床試験数:143,薬物数:221(DrugBank:79),標的遺伝子数:82,標的パスウェイ数:165
Searched query = "Sarcoidosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 143 trials found
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1NCT02824419May 201627/5/2016Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary SarcoidosisImaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary SarcoidosisPulmonary SarcoidosisDrug: Methionine;Drug: DOTANOCTurku University HospitalNULLRecruiting18 YearsN/ABoth10Phase 2/Phase 3Finland
2EUCTR2015-001815-11-FI19/04/201629/12/2015PET imaging of pulmonary sarcoidosisImaging of active granulomas with [18F]FDG and selected inflammatory PET tracers in pulmonary sarcoidosis Pulmonary sarcoidosis with active garnulomas in the lungs. The diagnosis is based on the clinical evidence or biopsy.
MedDRA version: 18.1Level: PTClassification code 10037430Term: Pulmonary sarcoidosisSystem Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]
Product Name: 18F-fluorodeoxyglucose
Product Code: FDG
INN or Proposed INN: FLUORINE (18F) FLUDEOXYGLUCOSE
Product Name: C11-methionine
INN or Proposed INN: L-methionine
Other descriptive name: L-METHIONINE ([11C]METHYL)
Product Name: 68Ga-DOTANOC
INN or Proposed INN: DOTANOC
Other descriptive name: DOTANOC
Turku PET CentreNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Finland

93. 原発性胆汁性胆管炎 [臨床試験数:230,薬物数:215(DrugBank:51),標的遺伝子数:34,標的パスウェイ数:107
Searched query = "Primary biliary cholangitis", "Primary biliary cirrhosis", "PBC"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 230 trials found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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1NCT02557360November 201521/9/2015Effectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary CirrhosisEffectiveness of S-adenosyl-L-methionine in Patients With Primary Biliary CirrhosisPrimary Biliary CirrhosisDietary Supplement: S-adenosyl-L-methioninePomeranian Medical University SzczecinLaval UniversityCompletedN/AN/AAll24Phase 4Poland
2NCT00125281July 25, 200529/7/2005SAMe to Treat Biliary Cirrhosis SymptomsS-Adenosyl Methionine for Symptomatic Treatment of Primary Biliary CirrhosisLiver Cirrhosis, BiliaryDrug: S-adenosyl-methionine (SAMe) capsulesNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLTerminated21 YearsN/AAll50Phase 2United States

229. 肺胞蛋白症(自己免疫性又は先天性) [臨床試験数:35,薬物数:30(DrugBank:8),標的遺伝子数:3,標的パスウェイ数:12
Searched query = "Autoimmune pulmonary alveolar proteinosis", "Congenital pulmonary alveolar proteinosis", "Hereditary pulmonary alveolar proteinosis", "Pulmonary alveolar proteinosis", "PAP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 35 trial found
No.TrialIDDate_
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Public_titleScientific_titleConditionInterventionPrimary_
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1NCT03887169September 16, 201912/3/2019Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.Pulmonary Alveolar Proteinosis;Mutation Ala393Thr of the MARS Gene;mutationSer567Leu of the MARS GeneDrug: Methionine;Drug: Vitamin B12, B9, B6, C supplementation;Diagnostic Test: Methionine/homocysteine Dosage;Diagnostic Test: Thoracic CT scan;Diagnostic Test: Abdominal and liver ultrasound.;Diagnostic Test: Brain MRIAssistance Publique - Hôpitaux de ParisNULLCompletedN/A18 YearsAll3Phase 1/Phase 2France

298. 遺伝性膵炎 [臨床試験数:93,薬物数:168(DrugBank:51),標的遺伝子数:48,標的パスウェイ数:134
Searched query = "Hereditary pancreatitis", "Chronic pancreatitis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 93 trial found
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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1EUCTR2006-000087-83-GB19/12/200804/12/2007EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2EUROPAC2 trial to investigate the efficacy of ANTOX(vers) 1.2 and MGCT (magnesiocard) for the treatment of hereditary pancreatitis and idiopathic chronic pancreatitis. - EUROPAC2 Hereditary Pancreatitis and Idiopathic Chronic Pancreatitis
MedDRA version: 13.1Level: HLTClassification code 10033646Term: Acute and chronic pancreatitisSystem Organ Class: 10017947 - Gastrointestinal disorders
MedDRA version: 13.1Level: PTClassification code 10056976Term: Hereditary pancreatitisSystem Organ Class: 10010331 - Congenital, familial and genetic disorders
Trade Name: Magnesiocard 2.5mmol
Other descriptive name: MAGNESIUM ASPARTATE HYDROCHLORIDE
Product Name: ANTOX (vers) 1.2
Product Code: ANTOX
Other descriptive name: TOCOPHEROL
INN or Proposed INN: ASCORBIC ACID
Other descriptive name: SELENIUM
INN or Proposed INN: METHIONINE
University of LiverpoolThe Royal Liverpool and Broadgreen University Hospitals NHS TrustAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
240Phase 3United Kingdom

300. IgG4関連疾患 [臨床試験数:31,薬物数:33(DrugBank:16),標的遺伝子数:11,標的パスウェイ数:81
Searched query = "IgG4-related disease", "Autoimmune pancreatitis", "IgG4-related sclerosing cholangitis", "IgG4-related lacrimal gland, orbital, and salivary gland lesions", "IgG4-related kidney disease"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 31 trial found
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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agemax
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1JPRN-UMIN0000199082016/01/0101/01/2016Preliminary study of [11C]methionine PET/CT in the diagnosis of IgG4 related disease IgG4 related disease[11C]methionine PET/CT, [18F]FDG PET/CTSaitama Medical University International Medical CenterSaitama Medical University HospitalComplete: follow-up complete20years-oldNot applicableMale and Female30Not selectedJapan