Drug Description in Trials / DrugBank / KEGG DRUG /

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No.	Drug (Description in trials)	DrugBank	KEGG DRUG	KEGG GENES	KEGG PATHWAY	Disease ID
1	(-)-Epicatechin	[1] Epicatechin	-	-	-	[2] 86, 113
2	(18F)FPGLU	-	-	-	-	[1] 86
3	(Pyr1)apelin-13	-	-	-	-	[1] 86
4	(S)-2-(4,6-dimethylpyrimidin-2-yloxy)-3-methoxy-3,3-diphenylpropanoic acid	-	-	-	-	[1] 86
5	(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2- YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM	-	-	-	-	[1] 86
6	(S)-3-((3-(1-((6-(3,4-DIMETHOXYPHENYL)PRYAZIN-2-YL)AMINO)ETHYL)PHENYL)CARBAMOYL)-5-METHYLPRIDIN-1-IUM	-	-	-	-	[1] 86
7	Comment- IMP inhalation solution identical to ventavis inhalation solution, but IMP is in a different volume presentation. Please see covering letter.	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
8	10-nitro-9(E)-octadec-9-enoic acid	-	-	-	-	[1] 86
9	11C-ACETATE	[2] Acetate, Acetic acid C-11	-	-	-	[4] 6, 13, 86, 88
10	120 mg sodium nitrite inhalation solution	[1] Nitrite	-	-	-	[1] 86
11	129Xe Hyperpolarized	-	-	-	-	[1] 86
12	15 mg sodium nitrite inhalation solution	[1] Nitrite	-	-	-	[1] 86
13	150mg CXA-10	[1] CXA-10	-	-	-	[1] 86
14	171	-	-	-	-	[1] 86
15	2-(4-[5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy)-N-(methylsulfonyl)actamide	-	-	-	-	[1] 86
16	2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl) acetamide	[1] Acetamide	-	-	-	[1] 86
17	20 mg sildenafil citrate by mouth	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
18	20 mg/ml Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
19	25% MTD sodium nitrite inhalation solution	[1] Nitrite	-	-	-	[1] 86
20	400 mg BIA 5-1058	[1] BIA	-	-	-	[1] 86
21	45 mg sodium nitrite inhalation solution	[1] Nitrite	-	-	-	[1] 86
22	4AU76	-	-	-	-	[1] 86
23	66215-101	-	-	-	-	[1] 86
24	6R-BH4	[1] Sapropterin	[1] D08505	-	-	[3] 86, 124, 240
25	75mg CXA-10	[1] CXA-10	-	-	-	[1] 86
26	90 mg sodium nitrite inhalation solution	[1] Nitrite	-	-	-	[1] 86
27	: 2-{4-[(5,6-difenilpirazin-2-yl)(isopropil)amino]butoxi}-N-	-	-	-	-	[1] 86
28	[11C]-GSK2256098 500 MBq	[1] GSK2256098	-	-	-	[1] 86
29	[18F] FES	-	-	-	-	[1] 86
30	[18F]Fluoro-2-deoxy-2-D-glucose	[1] D-glucose	[1] D00009	-	-	[2] 86, 88
31	Access program - sildenafil citrate, Viagra, Revatio	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
32	ACE-011	-	-	-	-	[1] 86
33	ACE-011 / MK - 7962	-	-	-	-	[1] 86
34	ACE-011 / MK-7962	-	-	-	-	[1] 86
35	ACE-011/ MK-7962	-	-	-	-	[1] 86
36	Acetamide	[1] Acetamide	-	-	-	[2] 86, 154
37	Acetaminophen	[1] Acetaminophen	[1] D00217	[2] PTGS1, PTGS2 💬	[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬	[13] 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337
38	Acetate	[1] Acetate	-	-	-	[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
39	ACT - 064992	-	-	-	-	[1] 86
40	ACT-050089	-	-	-	-	[1] 86
41	ACT-050089 (Ro 61-0612)	-	-	-	-	[1] 86
42	ACT-064992	-	-	-	-	[5] 51, 85, 86, 88, 210
43	ACT-064992 / JNJ-67896062	-	-	-	-	[1] 86
44	ACT-064992/ JNJ-67896062	-	-	-	-	[1] 86
45	ACT-064992D	-	-	-	-	[1] 86
46	ACT-178418	-	-	-	-	[1] 86
47	ACT-293987	-	-	-	-	[3] 51, 86, 88
48	ACT-293987 (NS-304)	-	-	-	-	[1] 86
49	ACT-385781A	-	-	-	-	[1] 86
50	ACT-385781A (Actelion Epoprostenol)	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
51	ActRIIA-IgG1Fc	-	-	-	-	[1] 86
52	Adcirca	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
53	ADCIRCA 20 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
54	Adcirca®	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
55	Adempas	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[5] 51, 86, 88, 225, 299
56	Adempas (Riociguat, BAY63-2521)	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 86, 88
57	ADEMPAS - 0,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
58	ADEMPAS - 1 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 51, 86
59	ADEMPAS - 1,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 51, 86
60	ADEMPAS - 2 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 51, 86
61	ADEMPAS - 2,5 MG - COMPRESSA RIVESTITA CON FILM - USO ORALE - BLISTER (PP/ALU) - 42 COMPRESSE	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 51, 86
62	Adempas 0.5 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 86, 299
63	Adempas 0.5 mg Film Coated Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
64	Adempas 1 mg Film Coated Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
65	Adempas 1.0 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 86, 299
66	Adempas 1.5 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
67	Adempas 1.5 mg Film Coated Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
68	Adempas 2 mg Film Coated Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
69	Adempas 2.0 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 86, 299
70	Adempas 2.5 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
71	Adempas 2.5 mg Film Coated Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
72	Adempas®	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[2] 86, 88
73	Adempas® 0.5 mg film-coated tablets	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
74	Adempas® 1.0 mg film-coated tablets	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
75	Adempas® 1.5 mg film-coated tablets	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
76	Adempas® 2.0 mg film-coated tablets	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
77	Adempas® 2.5 mg film-coated tablets	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
78	Adempas¿ 0.5 mg compressa rivestita con film	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
79	Adempas¿ 1.0	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
80	Adempas¿ 1.5 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
81	Adempas¿ 2.0 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
82	Adempas¿ 2.5 mg	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
83	Adipose derived mesenchymal stem cells	-	-	-	-	[1] 86
84	AER-901 Solution for Nebulization	-	-	-	-	[1] 86
85	Aerosolized iloprost	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
86	AIR001	-	-	-	-	[1] 86
87	AIR001 (sodium nitrite inhalation solution)	[1] Nitrite	-	-	-	[1] 86
88	AIR001 Inhalation Solution	-	-	-	-	[1] 86
89	AIR001 Inhalation Solution (Expansion arm)	-	-	-	-	[1] 86
90	AL	-	-	-	-	[11] 5, 6, 7, 13, 28, 51, 67, 86, 97, 114, 127
91	Albuterol	[1] Salbutamol	[1] D02147	[1] ADRB2 💬	[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[7] 12, 13, 86, 89, 113, 256, 299
92	Albuterol.	[1] Salbutamol	[1] D02147	[1] ADRB2 💬	[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
93	Allogeneic Human Cardiosphere-Derived Stem Cells	-	-	-	-	[1] 86
94	Ambrisentan	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[7] 51, 84, 85, 86, 88, 210, 211
95	Ambrisentan - high dose	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
96	Ambrisentan - low dose	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
97	Ambrisentan 5 mg film-coated tablets	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
98	Ambrisentan 5mg film-coated tablets [marketed product]	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
99	Ambrisentan plus Spironolactone	[2] Ambrisentan, Spironolactone	[2] D00443 , D07077	[2] EDNRA, NR3C2 💬	[8] Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
100	Ambrisentan Tablet	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
101	AMN107	-	-	-	-	[2] 34, 86
102	Anakinra	[1] Anakinra	[1] D02934	[2] IL1R1, IL1R2 💬	[15] Amoebiasis, Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, Pathogenic Escherichia coli infection, Prostate cancer, Shigellosis, Th17 cell differentiation, Transcriptional misregulation in cancer 💬	[16] 2, 13, 15, 28, 37, 41, 46, 49, 50, 56, 84, 86, 97, 106, 107, 299
103	ANASTROZOLE	[1] Anastrozole	[1] D00960	[1] CYP19A1 💬	[3] Metabolic pathways, Ovarian steroidogenesis, Steroid hormone biosynthesis 💬	[3] 78, 86, 193
104	Angiotensin	[1] Angiotensin II	[2] D00150 , D02014	[2] AGTR1, AGTR2 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[7] 17, 19, 46, 66, 86, 222, 224
105	Apabetalone	[1] Apabetalone	[1] D11131	[4] BRD2, BRD3, BRD4, BRDT 💬	-	[1] 86
106	APD811	-	-	-	-	[1] 86
107	Apelin	-	-	-	-	[1] 86
108	AR392830	-	-	-	-	[1] 86
109	Aspirin	[1] Acetylsalicylic acid	[1] D00109	[2] PTGS1, PTGS2 💬	[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬	[12] 13, 22, 46, 49, 51, 58, 64, 86, 113, 158, 210, 231
110	Assigned pulmonary hypertension medication	-	-	-	-	[1] 86
111	Autologous EPCs transfected	-	-	-	-	[1] 86
112	Autologous EPCs transfected with human eNOS	-	-	-	-	[1] 86
113	AV-101	[1] AV-101	-	-	-	[2] 6, 86
114	Aviptadil	[1] Aviptadil	[1] D12127	-	-	[5] 49, 51, 84, 85, 86
115	AZD4831	-	-	-	-	[1] 86
116	Background PAH Therapy	-	-	-	-	[1] 86
117	Bardoxolone	[1] Bardoxolone	[1] D09584	-	-	[7] 66, 67, 84, 85, 86, 218, 222
118	Bardoxolone methyl	[2] Bardoxolone, Bardoxolone methyl	[2] D09584 , D09585	-	-	[7] 66, 67, 84, 85, 86, 218, 222
119	Bardoxolone methyl capsules	[2] Bardoxolone, Bardoxolone methyl	[2] D09584 , D09585	-	-	[4] 66, 67, 86, 222
120	BARDOXOLONE METHYL, CDDO-Me, CDDO-Methyl Ester, NSC 713200, Chemical Name: Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-, methyl ester	[2] Bardoxolone, Bardoxolone methyl	[2] D09584 , D09585	-	-	[1] 86
121	BAY 63-2521	-	-	-	-	[2] 86, 88
122	BAY 63-2521 0.06 %	-	-	-	-	[1] 86
123	BAY 63-2521 0.3 %	-	-	-	-	[1] 86
124	BAY 63-2521 coated tablets 0.5 mg	-	-	-	-	[2] 86, 88
125	BAY 63-2521 coated tablets 1 mg	-	-	-	-	[2] 86, 88
126	BAY 63-2521 coated tablets 1.5 mg	-	-	-	-	[2] 86, 88
127	BAY 63-2521 coated tablets 2 mg	-	-	-	-	[2] 86, 88
128	BAY 63-2521 coated tablets 2.5 mg	-	-	-	-	[2] 86, 88
129	BAY 63-2521 IR tablets 0.5 mg	-	-	-	-	[1] 86
130	BAY 63-2521 IR tablets 1 mg	-	-	-	-	[1] 86
131	BAY 63-2521 IR tablets 1.0 mg	-	-	-	-	[1] 86
132	BAY 63-2521 IR tablets 1.5 mg	-	-	-	-	[1] 86
133	BAY 63-2521 IR tablets 2.0 mg	-	-	-	-	[1] 86
134	BAY 63-2521 IR tablets 2.5 mg	-	-	-	-	[1] 86
135	BAY 63-2521 Tablet	-	-	-	-	[1] 86
136	BAY 63-2521 tablets 0.5 mg	-	-	-	-	[2] 86, 88
137	BAY 63-2521 tablets 1 mg	-	-	-	-	[2] 86, 88
138	BAY 63-2521 tablets 1.5 mg	-	-	-	-	[2] 86, 88
139	BAY 63-2521 tablets 2 mg	-	-	-	-	[2] 86, 88
140	BAY 63-2521 tablets 2.5 mg	-	-	-	-	[2] 86, 88
141	Bay Q 6256	-	-	-	-	[1] 86
142	BAY1237592	-	-	-	-	[2] 86, 88
143	BAY63-2521	-	-	-	-	[3] 51, 86, 299
144	Beetroot juice	-	-	-	-	[2] 67, 86
145	Benzbromaron	-	-	-	-	[1] 86
146	Benzbromaron AL	-	-	-	-	[1] 86
147	BENZBROMARONE	[1] Benzbromarone	[1] D01056	[1] SLC22A12 💬	-	[1] 86
148	Beraprost	[1] Beraprost	[1] D02720	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
149	Beraprost Sodium	[1] Beraprost	[1] D02720	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
150	Beraprost Sodium 314d Modified Release Tablets	[1] Beraprost	[1] D02720	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
151	Beraprost Sodium Modified Release	[1] Beraprost	[1] D02720	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
152	BH4	-	-	-	-	[5] 51, 86, 124, 240, 299
153	BIA	[1] BIA	-	-	-	[2] 6, 86
154	BIA 5-1058	[1] BIA	-	-	-	[1] 86
155	BIA-5-1058	[1] BIA	-	-	-	[1] 86
156	Biological DMARDs	-	-	-	-	[2] 86, 107
157	BISOPROLOL	[1] Bisoprolol	[1] D02342	[1] ADRB1 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[4] 58, 67, 86, 113
158	Bosentan	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[10] 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
159	Bosentan administration	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
160	Bosentan and Sildenafil	[2] Bosentan, Sildenafil	[3] D01227 , D07538 , D08514	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
161	BOSENTAN MONOHIDRATO	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
162	Bosentan monohydrat	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
163	BOSENTAN MONOHYDRATE	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[4] 51, 84, 86, 88
164	Bosentan, Ambrisentan	[2] Ambrisentan, Bosentan	[3] D01227 , D07077 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
165	BPS-314d-MR	-	-	-	-	[1] 86
166	BPS-MR	-	-	-	-	[1] 86
167	Bromure d'Ipratropium	[1] Ipratropium	-	-	-	[1] 86
168	BSF 208075	-	-	-	-	[1] 86
169	BSF 208075 or LU 208075	-	-	-	-	[1] 86
170	C07AB07	-	-	-	-	[1] 86
171	C225	-	-	-	-	[2] 51, 86
172	Capsaicin	[1] Capsaicin	[1] D00250	[1] TRPV1 💬	[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬	[3] 6, 86, 226
173	Captopril	[1] Captopril	[1] D00251	[1] ACE 💬	[6] Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬	[2] 17, 86
174	Carbon	[1] Activated charcoal	-	-	-	[6] 6, 85, 86, 96, 97, 158
175	Carbon monoxide	[2] Activated charcoal, Carbon monoxide	[1] D09706	-	-	[2] 85, 86
176	Carnitine	[1] Levocarnitine	[1] D02176	-	-	[9] 5, 13, 58, 86, 96, 97, 265, 298, 316
177	Carvedilol	[1] Carvedilol	[1] D00255	[5] ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2 💬	[13] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[4] 57, 86, 113, 210
178	Cetuximab	[1] Cetuximab	[1] D03455	[1] EGFR 💬	[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬	[2] 51, 86
179	Chlorhexidine	[1] Chlorhexidine	[1] D07668	-	-	[2] 86, 299
180	Cialis	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 51, 86
181	Cialis 10 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 86, 113
182	Cialis 2.5 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 86, 113
183	CIALIS 20 mg comprimidos recubiertos con película	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
184	Cialis 20 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 86, 113
185	Cialis 5 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 86, 113
186	Cicletanine	[1] Cicletanine	[1] D03487	-	-	[1] 86
187	Cicletanine hydrochloride	[1] Cicletanine	[1] D03487	-	-	[1] 86
188	Citrulline	[1] Citrulline	-	-	-	[2] 86, 113
189	CJNJ-68150420-ZZZ-G001 (ACT- 064992D)	-	-	-	-	[1] 86
190	CJNJ-68150420-ZZZ-G001 (ACT-064992D)	-	-	-	-	[1] 86
191	CJNJ-68150420-ZZZ-G001(ACT-064992D)	-	-	-	-	[1] 86
192	Clopidogrel	[1] Clopidogrel	[3] D07729 , D10823 , D10824	[1] P2RY12 💬	[1] Platelet activation 💬	[3] 49, 51, 86
193	Coenzyme Q-10	[1] Ubidecarenone	[1] D01065	-	-	[1] 86
194	Coenzyme Q-10 in Normal Control subjects	[1] Ubidecarenone	[1] D01065	-	-	[1] 86
195	Coenzyme Q-10 in Pulmonary Hypertension subjects	[1] Ubidecarenone	[1] D01065	-	-	[1] 86
196	Combination Product:	-	-	-	-	[1] 86
197	Combination Product: Implantable System for Remodulin (treprostinil)	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
198	Combination Product: Treprostinil via implanted pump	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
199	Commercial Ventavis® (iloprost)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
200	Conivaptan	[1] Conivaptan	[1] D07748	[2] AVPR1A, AVPR2 💬	[5] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬	[1] 86
201	Conventional drug therapy(expectorant,bronchodilator)	-	-	-	-	[1] 86
202	CosmoFer	-	-	-	-	[3] 86, 96, 97
203	CS1 Administration	-	-	-	-	[1] 86
204	Current marketed FLOLAN (epoprostenol sodium)	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
205	CXA-10	[1] CXA-10	-	-	-	[2] 86, 222
206	D-glucose	[1] D-glucose	[1] D00009	-	-	[3] 49, 86, 88
207	D.3.6.2 - dose massima specificare: giornaliera	-	-	-	-	[1] 86
208	Dapagliflozin	[1] Dapagliflozin	[1] D08897	[1] SLC5A2 💬	-	[7] 19, 49, 66, 67, 86, 88, 222
209	Dapagliflozin 10 MG [Farxiga]	[1] Dapagliflozin	[1] D08897	[1] SLC5A2 💬	-	[2] 86, 88
210	DHEA	[1] Prasterone	[1] D08409	[3] AR, ESR1, ESR2 💬	[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬	[3] 49, 86, 96
211	DHEA tablet	[1] Prasterone	[1] D08409	[3] AR, ESR1, ESR2 💬	[12] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Oocyte meiosis, Pathways in cancer, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬	[1] 86
212	Dichloroacetate	[1] Dichloroacetic acid	-	-	-	[1] 86
213	Dichloroacetate Sodium	[2] Dichloroacetic acid, Sodium dichloroacetate	[1] D05857	[3] PDK2, PDK3, PDK4 💬	[1] Diabetic cardiomyopathy 💬	[1] 86
214	Diet	-	-	-	-	[4] 86, 97, 240, 299
215	Dietanolamina de treprostinilo	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
216	Diltiazem	[1] Diltiazem	[1] D07845	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[3] 51, 58, 86
217	Diltiazem Hydrochloride	[1] Diltiazem	[1] D07845	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
218	DIMETHYL FUMARATE	[1] Dimethyl fumarate	[1] D03846	[1] KEAP1 💬	[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬	[4] 13, 51, 86, 296
219	Dimethyl Fumarate (DMF)	[1] Dimethyl fumarate	[1] D03846	[1] KEAP1 💬	[6] Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬	[3] 13, 51, 86
220	Diphenhydramine	[1] Diphenhydramine	[1] D00300	[1] HRH1 💬	[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬	[8] 11, 13, 49, 51, 70, 86, 222, 256
221	Dobutamine	[1] Dobutamine	[1] D03879	[1] ADRB1 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[4] 57, 58, 86, 215
222	Dobutamine test	[1] Dobutamine	[1] D03879	[1] ADRB1 💬	[11] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
223	Duo-Therapy with Sildenafil + Bosentan	[2] Bosentan, Sildenafil	[3] D01227 , D07538 , D08514	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
224	EFI/ACT-385781A	-	-	-	-	[1] 86
225	Elafin	[1] Elafin	-	-	-	[1] 86
226	Endothelin receptor antagonist therapy	-	-	-	-	[1] 86
227	Endothelin Receptor Antagonists	-	-	-	-	[1] 86
228	Endothelin-3	-	-	-	-	[1] 86
229	ENOS transfected EPCs will be delivered via a PA line	-	-	-	-	[1] 86
230	Epicatechin	[1] Epicatechin	-	-	-	[2] 86, 113
231	EPOPROSTENOL	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
232	Epoprostenol for injection	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
233	EPOPROSTENOL SODICO	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
234	EPOPROSTENOL SODIUM	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
235	Epoprostenol-Actelion	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
236	Epoprostenolo per iniezione	-	-	-	-	[1] 86
237	Equal	-	-	-	-	[4] 6, 13, 67, 86
238	ERA and PDE-5I (Sildenafil, Tadalafil, Bosentan, Macitentan)	[4] Bosentan, Macitentan, Sildenafil, Tadalafil	[5] D01227 , D02008 , D07538 , D08514 , D10135	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
239	ERA as specific PAH treatment	-	-	-	-	[1] 86
240	Erbitux	[1] Cetuximab	[1] D03455	[1] EGFR 💬	[48] Adherens junction, Bladder cancer, Breast cancer, Calcium signaling pathway, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Coronavirus disease - COVID-19, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH signaling pathway, HIF-1 signaling pathway, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanoma, MicroRNAs in cancer, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis 💬	[2] 51, 86
241	Esomeprazole	[1] Esomeprazole	[1] D07917	[2] ATP4A, ATP4B 💬	[4] Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬	[8] 13, 46, 86, 98, 107, 113, 298, 299
242	ESR-specific PET scan	-	-	-	-	[1] 86
243	Esuberaprost	-	-	-	-	[1] 86
244	Eutonic Treprostinil Solution	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
245	Famotidine	[1] Famotidine	[1] D00318	[1] HRH2 💬	[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬	[5] 6, 46, 86, 98, 107
246	Famotidine 20 MG	[1] Famotidine	[1] D00318	[1] HRH2 💬	[3] Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction 💬	[1] 86
247	FDC macitentan/tadalafil	[2] Macitentan, Tadalafil	[2] D02008 , D10135	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
248	Ferinject	-	-	-	-	[2] 86, 299
249	Ferinject or CosmoFer	-	-	-	-	[1] 86
250	FERRIC CARBOXYMALTOSE	[1] Ferric carboxymaltose	[1] D08920	-	-	[4] 86, 96, 97, 299
251	Ferricarboxymaltose	-	-	-	-	[1] 86
252	FK506 level 2-3 ng/ml	-	-	-	-	[1] 86
253	FK506 level 3-5 ng/ml	-	-	-	-	[1] 86
254	FK506 level < 2 ng/ml	-	-	-	-	[1] 86
255	Flolan	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
256	FLOLAN injection with currently marketed diluent	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
257	FLOLAN injection with reformulated diluent	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
258	FLOLAN TM and Glycine Diluent	[2] Epoprostenol, Glycine	[2] D00011 , D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
259	Flolan®	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
260	FLOLAN™ and Glycine Diluent	[2] Epoprostenol, Glycine	[2] D00011 , D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
261	FLUOXETINE	[1] Fluoxetine	[1] D00326	[1] SLC6A4 💬	[2] Serotonergic synapse, Synaptic vesicle cycle 💬	[4] 13, 17, 78, 86
262	Forxiga	[1] Dapagliflozin	[1] D08897	[1] SLC5A2 💬	-	[2] 86, 88
263	Forxiga (dapagliflozin)	[1] Dapagliflozin	[1] D08897	[1] SLC5A2 💬	-	[2] 86, 88
264	Fulvestrant	[1] Fulvestrant	[1] D01161	[2] ESR1, ESR2 💬	[10] Breast cancer, Chemical carcinogenesis - receptor activation, Endocrine and other factor-regulated calcium reabsorption, Endocrine resistance, Estrogen signaling pathway, GnRH secretion, Pathways in cancer, Prolactin signaling pathway, Proteoglycans in cancer, Thyroid hormone signaling pathway 💬	[1] 86
265	Furosemide	[1] Furosemide	[1] D00331	[1] SLC12A2 💬	[3] Pancreatic secretion, Salivary secretion, Vibrio cholerae infection 💬	[2] 6, 86
266	G04BE03	-	-	-	-	[1] 86
267	G04BE03- Sildenafil - sildenafil (citrato)	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
268	G04BE08	-	-	-	-	[1] 86
269	GB002	-	-	-	-	[1] 86
270	GB002 (seralutinib)	-	-	-	-	[1] 86
271	GB002 Capsules	-	-	-	-	[1] 86
272	GLIVEC	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[2] 51, 86
273	GLIVEC 100 mg comprimidos recubiertos con película	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[2] 34, 86
274	Glivec 100 mg Filmtabletten	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[2] 51, 86
275	Glivec 100 mg Hartkapsel	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
276	Glivec®	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
277	Glivec® 100 mg Filmtabletten	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
278	Glucose	[1] Dextrose, unspecified form	-	-	-	[12] 2, 6, 13, 49, 50, 66, 86, 88, 96, 97, 257, 299
279	GLYCINE	[1] Glycine	[1] D00011	-	-	[5] 35, 60, 86, 226, 299
280	GMA301 Injection	-	-	-	-	[1] 86
281	Gold	[1] Gold	-	-	-	[43] 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 63, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 167, 171, 193, 218, 222, 224, 226, 227, 230, 271, 291, 296, 298, 310, 318
282	GS-4997 18 mg	-	-	-	-	[1] 86
283	GS-4997 2 mg	-	-	-	-	[1] 86
284	GS-4997 6 mg	-	-	-	-	[1] 86
285	GSK1325760	-	-	-	-	[2] 86, 88
286	GSK1325760A	-	-	-	-	[1] 86
287	GSK2256098	[1] GSK2256098	-	-	-	[1] 86
288	GSK2586881	-	-	-	-	[1] 86
289	HGP1206	-	-	-	-	[1] 86
290	Hydroxyurea	[1] Hydroxyurea	[1] D00341	[1] RRM2 💬	[7] Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Nucleotide metabolism, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬	[8] 3, 13, 19, 20, 65, 85, 86, 284
291	Hyperpolarized 129Xe	-	-	-	-	[1] 86
292	Hyperpolarized Xe129	-	-	-	-	[4] 51, 85, 86, 299
293	HypotonicTreprostinil Solution	-	-	-	-	[1] 86
294	I.v. selexipag	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
295	Ilomedin 20	-	-	-	-	[1] 86
296	Ilomedin 20 [20 µg / ml]	-	-	-	-	[1] 86
297	Iloprost	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[4] 51, 84, 85, 86
298	Iloprost (5 µg)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
299	Iloprost (Ventavis BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
300	Iloprost (Ventavis inhaled, BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
301	Iloprost (Ventavis, BAYQ 6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
302	Iloprost (Ventavis, BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
303	Iloprost (Ventavis®)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
304	Iloprost Inhalation Solution (Ventavis)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[2] 85, 86
305	Iloprost PD-15	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
306	Iloprost PD-6	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
307	Iloprost,(Ventavis, BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
308	Imatinib	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[12] 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
309	IMATINIB MESILATE	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[3] 13, 86, 88
310	Imatinib Mesylate	[1] Imatinib	[1] D08066	[3] ABL1, KIT, PDGFRA 💬	[32] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[5] 13, 28, 34, 51, 86
311	Inhaled dry powder treprostinil (LIQ861)	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
312	Inhaled Iloprost (5 µg)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
313	Inhaled iloprost (Ventavis, BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
314	Inhaled Nitric Oxide	[1] Nitric Oxide	[1] D00074	-	-	[2] 85, 86
315	Inhaled nitric oxide & INOpulse delivery	[1] Nitric Oxide	[1] D00074	-	-	[1] 86
316	Inhaled nitric oxide 75 mcg/kg IBW/hr	[1] Nitric Oxide	[1] D00074	-	-	[2] 85, 86
317	Inhaled NO with pulsed delivery	-	-	-	-	[1] 86
318	Inhaled prostacyclin	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
319	Inhaled Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[3] 84, 85, 86
320	INO	-	-	-	-	[2] 85, 86
321	Intestinal microbiota transplant (IMT)	-	-	-	-	[1] 86
322	Intravenous administration of ferric carboxymaltose	[1] Ferric carboxymaltose	[1] D08920	-	-	[1] 86
323	Intravenous Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
324	Ipratropium	[1] Ipratropium	-	-	-	[2] 6, 86
325	Iron supplement	-	-	-	-	[1] 86
326	JNJ-67896049	-	-	-	-	[1] 86
327	JNJ-67896049 (ACT-293987)	-	-	-	-	[1] 86
328	JNJ-67896062 / ACT-064992	-	-	-	-	[2] 86, 88
329	JNJ-67896062/ ACT-064992	-	-	-	-	[2] 86, 88
330	JNJ-67896062/ACT-064922	-	-	-	-	[1] 86
331	JTT-251	-	-	-	-	[1] 86
332	KAR5585 Capsules	-	-	-	-	[1] 86
333	L-Carnitine	[1] Levocarnitine	[1] D02176	-	-	[7] 13, 86, 96, 97, 265, 298, 316
334	L-Citrulline Malate	[1] Citrulline	-	-	-	[1] 86
335	L606 (Liposomal Treprostinil) Inhalation Solution 51ug	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
336	Levitra	[1] Vardenafil	[1] D08668	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 13, 86
337	Lidocaine	[1] Lidocaine	[2] D00358 , D08127	[5] SCN1A, SCN2A, SCN3A, SCN5A, SCN9A 💬	[3] Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬	[12] 6, 13, 22, 34, 46, 51, 70, 86, 107, 168, 226, 256
338	LIQ861 100 µg	-	-	-	-	[1] 86
339	LIQ861 106 µg	-	-	-	-	[1] 86
340	LIQ861 25 µg	-	-	-	-	[1] 86
341	LIQ861 26.5 µg	-	-	-	-	[1] 86
342	LIQ861 50 µg	-	-	-	-	[1] 86
343	LIQ861 53 µg	-	-	-	-	[1] 86
344	LIQ861 75 µg	-	-	-	-	[1] 86
345	LIQ861 79.5 µg	-	-	-	-	[1] 86
346	LIQ861 Inhaled Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
347	LISURIDE	[1] Lisuride	[1] D08132	[3] DRD2, DRD3, DRD4 💬	[8] Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬	[2] 6, 86
348	Lloprost(Ventavis,BAYQ6252, 10 µg/mL)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
349	Lloprost(Ventavis,BAYQ6252, 20 µg/mL)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
350	LTP001	-	-	-	-	[2] 85, 86
351	LY450190	-	-	-	-	[1] 86
352	Macitentan	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[5] 51, 85, 86, 88, 210
353	Macitentan (ACT-064992)	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
354	Macitentan 10 mg	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[3] 51, 86, 88
355	Macitentan 10 mg tablet, once daily.	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
356	Macitentan 37.5 mg	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
357	Macitentan 75 mg	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
358	MACITENTAN COMPRESSE	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 86, 88
359	Macitentan Group	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
360	MACITENTAN TABLETS	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 86, 88
361	MD-711	-	-	-	-	[1] 86
362	Medical air	[2] Medical air, Oxygen	[1] D00003	-	-	[3] 85, 86, 193
363	Metformin	[1] Metformin	[1] D04966	[2] PRKAA1, PRKAA2 💬	[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬	[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
364	Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo	-	-	-	-	[1] 86
365	Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-yl]-5-pyrimidinyl(methyl)carb	-	-	-	-	[2] 86, 88
366	Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]meth	-	-	-	-	[2] 86, 88
367	Methylprednisolone	[1] Methylprednisolone	[1] D00407	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction 💬	[46] 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296
368	MK-4836	-	-	-	-	[2] 86, 88
369	MK-5475	-	-	-	-	[1] 86
370	MK-7962	-	-	-	-	[1] 86
371	MK-8892	-	-	-	-	[1] 86
372	MN-08 24 mg/day	-	-	-	-	[1] 86
373	MN-08 60 mg/day	-	-	-	-	[1] 86
374	Mono-Therapy with Sildenafil	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
375	Morphine	[1] Morphine	[1] D08233	[1] OPRM1 💬	[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬	[5] 36, 46, 70, 85, 86
376	MORPHINE SULFATE	[2] Morphine, Sulfate ion	[1] D08233	[1] OPRM1 💬	[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬	[3] 46, 85, 86
377	Moxifloxacin	[1] Moxifloxacin	[1] D08237	-	-	[9] 2, 6, 46, 49, 85, 86, 113, 240, 299
378	Moxifloxacin 400 mg	[1] Moxifloxacin	[1] D08237	-	-	[1] 86
379	MultiHance	[1] Gadobenic acid	[1] D08018	-	-	[2] 86, 88
380	Nab-sirolimus (also known as ABI-009, nab-rapamycin, albumin-bound rapamycin)	[1] Sirolimus	[1] D00753	[1] MTOR 💬	[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬	[1] 86
381	Nebulized combination ipratropium bromide with salbutamol	[2] Ipratropium, Salbutamol	[1] D02147	[1] ADRB2 💬	[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
382	Nebulized ipratropium bromide	[1] Ipratropium	-	-	-	[1] 86
383	New thermo stable formulation of epoprostenol sodium	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
384	Nicardipine	[1] Nicardipine	[1] D08270	[4] CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬	[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 70, 86
385	Nilotinib	[1] Nilotinib	[1] D08953	[4] ABL1, KIT, PDGFRA, PDGFRB 💬	[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[5] 6, 8, 34, 51, 86
386	Nilotinib 50 mg	[1] Nilotinib	[1] D08953	[4] ABL1, KIT, PDGFRA, PDGFRB 💬	[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
387	NITRIC OXIDE	[1] Nitric Oxide	[1] D00074	-	-	[7] 85, 86, 88, 210, 251, 294, 299
388	Nitric Oxide for inhalation	[1] Nitric Oxide	[1] D00074	-	-	[2] 86, 299
389	Nitric Oxide generated by the GeNO nitrosyl delivery system	[1] Nitric Oxide	[1] D00074	-	-	[1] 86
390	Nitric Oxide plus Oxygen	[2] Nitric Oxide, Oxygen	[2] D00003 , D00074	-	-	[1] 86
391	Nitrite	[1] Nitrite	-	-	-	[2] 58, 86
392	Nitrosyl	[1] Nitric Oxide	[1] D00074	-	-	[1] 86
393	NO	-	-	-	-	[9] 6, 46, 58, 62, 86, 97, 222, 299, 321
394	Non-Biologic DMARDs	-	-	-	-	[3] 46, 86, 107
395	NS-304	-	-	-	-	[3] 70, 86, 88
396	Null	-	-	-	-	[16] 6, 13, 15, 28, 37, 46, 49, 51, 63, 86, 90, 96, 97, 107, 145, 271
397	NX1011	-	-	-	-	[1] 86
398	Observational study with patients treated with Tracleer, Ventavis, Veletri, Opsumit and/or Uptravi	[4] Epoprostenol, Iloprost, Macitentan, Selexipag	[4] D00106 , D02721 , D09994 , D10135	[3] EDNRA, EDNRB, PTGIR 💬	[10] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Platelet activation, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
399	Olaparib	[1] Olaparib	[1] D09730	[2] PARP1, PARP2 💬	[5] Apoptosis, Base excision repair, Diabetic cardiomyopathy, NF-kappa B signaling pathway, Necroptosis 💬	[2] 86, 285
400	Opsumit	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[3] 86, 88, 210
401	Opsumit (macitentan)	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
402	Opsumit®	[1] Macitentan	[1] D10135	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[3] 86, 88, 210
403	Oral anticoagulant treatment	-	-	-	-	[1] 86
404	Oral ERA	-	-	-	-	[1] 86
405	Oral PDE5 inhibitors	-	-	-	-	[1] 86
406	Oral selexipag (Uptravi)	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
407	Oral sildenafil	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
408	Oral treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[2] 51, 86
409	Oral treprostinil (UT-15C) Sustained Release Tablets	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
410	Ossido Nitrico	-	-	-	-	[1] 86
411	Oxygen	[1] Oxygen	[1] D00003	-	-	[13] 6, 49, 70, 85, 86, 88, 90, 96, 168, 193, 271, 299, 330
412	Oxygen supplementation	[1] Oxygen	[1] D00003	-	-	[1] 86
413	Oxygen, liquid	[1] Oxygen	[1] D00003	-	-	[2] 86, 88
414	PAH	-	-	-	-	[3] 49, 53, 86
415	PAH medication	-	-	-	-	[1] 86
416	PAH Therapies	-	-	-	-	[1] 86
417	Parenteral Remodulin (treprostinil) injection	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
418	Parenteral Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
419	PB1046	-	-	-	-	[1] 86
420	PB1046 Subcutaneous Injection	-	-	-	-	[1] 86
421	PB1046, VIP-ELP1-120, Vasomera	-	-	-	-	[1] 86
422	PDE5 inhibitor	-	-	-	-	[1] 86
423	Pemziviptadil (PB1046) Injection	-	-	-	-	[1] 86
424	Pentoxifylline	[1] Pentoxifylline	[1] D00501	-	-	[12] 26, 56, 84, 86, 93, 96, 97, 113, 220, 222, 296, 298
425	PF-00489791	[1] PF-00489791	-	-	-	[1] 86
426	Pioglitazone	[1] Pioglitazone	[1] D08378	[1] PPARG 💬	[11] AMPK signaling pathway, Huntington disease, Lipid and atherosclerosis, Longevity regulating pathway, Non-alcoholic fatty liver disease, Osteoclast differentiation, PPAR signaling pathway, Pathways in cancer, Thermogenesis, Thyroid cancer, Transcriptional misregulation in cancer 💬	[17] 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
427	Placebo	-	-	-	-	[28] 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
428	PLX-PAD	[1] Placental Mesenchymal Stem Cells	-	-	-	[1] 86
429	Prednisone	[1] Prednisone	[1] D00473	[1] NR3C1 💬	[1] Neuroactive ligand-receptor interaction 💬	[45] 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331
430	Prostacyclin	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
431	Prostacyclin Receptor Agonist	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
432	Puri-Nethol	-	-	-	-	[3] 86, 96, 97
433	Q4W GMA301 IV injections (1000 mg)	-	-	-	-	[1] 86
434	Q4W GMA301 IV injections (300 mg)	-	-	-	-	[1] 86
435	Q4W GMA301 IV injections (600 mg)	-	-	-	-	[1] 86
436	QCC374	-	-	-	-	[1] 86
437	QCC374 0.015 mg	-	-	-	-	[1] 86
438	QCC374 0.06 mg	-	-	-	-	[1] 86
439	QTI571	-	-	-	-	[1] 86
440	Qutenza	-	-	-	-	[1] 86
441	Qutenza (8% capsaicin)	[1] Capsaicin	[1] D00250	[1] TRPV1 💬	[2] Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction 💬	[1] 86
442	RALINEPAG	[1] Ralinepag	[1] D10725	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
443	Ranolazine	[1] Ranolazine	[1] D05700	-	-	[6] 2, 58, 86, 96, 113, 114
444	Rapamycin	[1] Sirolimus	[1] D00753	[1] MTOR 💬	[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬	[18] 15, 34, 35, 46, 49, 51, 53, 60, 61, 67, 86, 89, 96, 157, 158, 193, 256, 279
445	Rapid Dose Titration Group of Subcutaneous Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
446	Recombinant Human Angiotensin-Converting Enzyme 2	[2] Alunacedase alfa, Angiotensin II	[2] D00150 , D02014	[2] AGTR1, AGTR2 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
447	Recombinant Human Angiotensin-converting enzyme 2 (ACE2), APN01	[2] Alunacedase alfa, Angiotensin II	[2] D00150 , D02014	[2] AGTR1, AGTR2 💬	[16] AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Coronavirus disease - COVID-19, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Neuroactive ligand-receptor interaction, Pathways in cancer, Phospholipase D signaling pathway, Renin secretion, Renin-angiotensin system, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
448	Remodulin	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[2] 86, 88
449	Remodulin (treprostinil sodium)	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
450	Remodulin® (treprostinil) 1 mg/ml solution for infusion	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
451	Remodulin® (treprostinil) 10 mg/ml solution for infusion	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
452	Remodulin® (treprostinil) 2.5 mg/ml solution for infusion	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
453	Remodulin® (treprostinil) 5 mg/ml solution for infusion	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
454	Revatio	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[3] 85, 86, 113
455	Revatio 10 mg/ml powder for oral suspension	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
456	Revatio 20 mg film coated tablets	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
457	Revatio 20 mg film-coated tablets	-	-	-	-	[1] 86
458	Revatio 20 mg Filmtabletten	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
459	REVATIO 20 mg, comprimidos recubiertos con película	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
460	Revatio inyectable	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
461	Revatio oral	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
462	Revatio POS	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
463	Revatio Tablets	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
464	Revatio ® 20 mg film-coated tablets	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
465	Revatio®	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
466	Riciguat Group	-	-	-	-	[1] 86
467	Rifampin	[1] Rifampicin	[1] D00211	-	-	[5] 6, 13, 84, 86, 299
468	RIOCIGUAT	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[6] 51, 84, 86, 88, 225, 299
469	Riociguat (Adempas, BAY63-2521)	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[4] 51, 86, 88, 299
470	Riociguat (BAY63-2521)	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
471	Riociguat granules 0.3% for oral application	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
472	Riociguat Oral Product	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
473	Riociguat Oral Tablet	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[3] 51, 86, 88
474	Riociguat Pill	[1] Riociguat	[1] D09572	[3] GUCY1A1, GUCY1A2, GUCY1B1 💬	[11] Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬	[1] 86
475	Ritonavir	[1] Ritonavir	[1] D00427	-	-	[3] 2, 86, 265
476	RITUXIMAB	[1] Rituximab	[1] D02994	[1] MS4A1 💬	[1] Hematopoietic cell lineage 💬	[48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
477	Ro 47-0203	-	-	-	-	[4] 51, 85, 86, 88
478	Ro 47-0203 / ACT-050088	-	-	-	-	[1] 86
479	Ro-47-0203	-	-	-	-	[1] 86
480	Ro-47-0203/029	-	-	-	-	[1] 86
481	Ro47-0203	-	-	-	-	[1] 86
482	Ro47-0203 / ACT-050088	-	-	-	-	[2] 51, 86
483	RoActemra	[1] Tocilizumab	[1] D02596	[1] IL6R 💬	[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	[11] 40, 41, 44, 46, 50, 51, 86, 107, 266, 271, 331
484	Rodatristat ethyl	-	-	-	-	[1] 86
485	Rodatristat ethyl 300 mg tablet BID	-	-	-	-	[1] 86
486	Rodatristat ethyl 600 mg BID	-	-	-	-	[1] 86
487	RT234 - vardenafil inhalation powder	[1] Vardenafil	[1] D08668	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
488	RTA 402	-	-	-	-	[3] 67, 86, 218
489	RVG 33865	-	-	-	-	[1] 86
490	RVT-1201	-	-	-	-	[1] 86
491	Salbutamol	[1] Salbutamol	[1] D02147	[1] ADRB2 💬	[9] Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[8] 3, 11, 49, 85, 86, 111, 256, 299
492	Saline	-	-	-	-	[10] 6, 13, 17, 53, 67, 78, 86, 97, 168, 299
493	Sapropterin	[1] Sapropterin	[1] D08505	-	-	[3] 86, 124, 240
494	Sapropterin dihydrochloride (6R-BH4)	[1] Sapropterin	[1] D08505	-	-	[1] 86
495	Saquinavir	[1] Saquinavir	[1] D00429	-	-	[2] 86, 265
496	Saquinavir and ritonavir	[2] Ritonavir, Saquinavir	[2] D00427 , D00429	-	-	[1] 86
497	SATRALIZUMAB	[1] Satralizumab	[1] D11079	[1] IL6R 💬	[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	[3] 11, 13, 86
498	Satralizumab (Genetical Recombination)	[1] Satralizumab	[1] D11079	[1] IL6R 💬	[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	[1] 86
499	Sauerstoff	-	-	-	-	[2] 86, 88
500	SELEXIPAG	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[5] 51, 70, 84, 86, 88
501	Selexipag (Uptravi)	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
502	Selexipag, ACT-293987 (NS-304)	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
503	Selonsertib	[1] Selonsertib	[1] D10988	[1] MAP3K5 💬	[20] Alcoholic liver disease, Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Huntington disease, Lipid and atherosclerosis, MAPK signaling pathway, Neurotrophin signaling pathway, Non-alcoholic fatty liver disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Protein processing in endoplasmic reticulum, Sphingolipid signaling pathway, Spinocerebellar ataxia, TNF signaling pathway, Thermogenesis, Tight junction 💬	[1] 86
504	Seralutinib	-	-	-	-	[1] 86
505	Serine	[1] Serine	[1] D00016	-	-	[4] 2, 6, 86, 96
506	Sham O2 (medical air)	[2] Medical air, Oxygen	[1] D00003	-	-	[1] 86
507	SILDENAF	-	-	-	-	[1] 86
508	Sildenafil	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[17] 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
509	Sildenafil (as citrate)	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
510	Sildenafil (REVATIO)	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
511	Sildenafil (Revatio) 20 mg TID	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
512	Sildenafil 20mg	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 51, 86
513	Sildenafil 20mg and Bosentan 62.5mg	[2] Bosentan, Sildenafil	[3] D01227 , D07538 , D08514	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 51, 86
514	Sildenafil citrate	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[4] 51, 85, 86, 225
515	Sildenafil citrate (UK-92,480)	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
516	Sildenafil Filmtabletten	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
517	Sildenafil singly or in association with Bosentan	[2] Bosentan, Sildenafil	[3] D01227 , D07538 , D08514	[3] EDNRA, EDNRB, PDE5A 💬	[11] Calcium signaling pathway, Melanogenesis, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
518	SILDENAFILO	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
519	Simvastatin	[1] Simvastatin	[1] D00434	[1] HMGCR 💬	[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	[21] 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
520	Simvastatin 40 mg	[1] Simvastatin	[1] D00434	[1] HMGCR 💬	[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	[1] 86
521	Simvastatin 40 mg tablets	[1] Simvastatin	[1] D00434	[1] HMGCR 💬	[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬	[1] 86
522	Sirolimus	[1] Sirolimus	[1] D00753	[1] MTOR 💬	[51] AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬	[35] 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 98, 137, 157, 158, 192, 222, 277, 278, 279, 280, 281, 283, 300, 331
523	Sitaxentan	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
524	Sitaxentan sodium	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
525	Sitaxsentan	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
526	Sitaxsentan alone	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
527	Sitaxsentan and Sildenafil	[2] Sildenafil, Sitaxentan	[2] D07171 , D08514	[2] EDNRA, PDE5A 💬	[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
528	SITAXSENTAN SODIUM	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
529	Slow Dose Titration Group of Subcutaneous Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
530	SODIUM NITRITE	[1] Nitrite	-	-	-	[1] 86
531	Sodium Nitrite Inhalation Solution	[1] Nitrite	-	-	-	[1] 86
532	Sodium tanshinone IIA sulfonate diluted with 5% glucose solution,20mg sildenafil citrate by mouth	[2] Dextrose, unspecified form, Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
533	Sorafenib	[1] Sorafenib	[1] D08524	[8] BRAF, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET 💬	[89] Acute myeloid leukemia, Alcoholism, Alzheimer disease, Apelin signaling pathway, Apoptosis, Autophagy - animal, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Breast cancer, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Choline metabolism in cancer, Chronic myeloid leukemia, Colorectal cancer, Cushing syndrome, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endometrial cancer, ErbB signaling pathway, Estrogen signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Fluid shear stress and atherosclerosis, Focal adhesion, FoxO signaling pathway, Gap junction, Gastric cancer, Glioma, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Hepatocellular carcinoma, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Influenza A, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-small cell lung cancer, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parathyroid hormone synthesis, secretion and action, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Prostate cancer, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Renal cell carcinoma, Salmonella infection, Serotonergic synapse, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, Thyroid cancer, Thyroid hormone signaling pathway, Transcriptional misregulation in cancer, Tuberculosis, VEGF signaling pathway, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway, mTOR signaling pathway 💬	[2] 34, 86
534	SOTATERCEPT	[1] Sotatercept	[1] D09670	[1] ACVR2A 💬	[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬	[2] 86, 284
535	Sotatercept - 45 mg/vial	[1] Sotatercept	[1] D09670	[1] ACVR2A 💬	[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬	[1] 86
536	Sotatercept - 60 mg/vial	[1] Sotatercept	[1] D09670	[1] ACVR2A 💬	[4] Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬	[1] 86
537	Spironolactone	[1] Spironolactone	[1] D00443	[1] NR3C2 💬	[1] Aldosterone-regulated sodium reabsorption 💬	[8] 46, 58, 67, 86, 113, 210, 218, 225
538	Spironolactone and conivaptan	[2] Conivaptan, Spironolactone	[2] D00443 , D07748	[3] AVPR1A, AVPR2, NR3C2 💬	[6] Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vascular smooth muscle contraction, Vasopressin-regulated water reabsorption 💬	[1] 86
539	Spironolactone captopril carvedilol	[3] Captopril, Carvedilol, Spironolactone	[3] D00251 , D00255 , D00443	[7] ACE, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, NR3C2 💬	[19] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone-regulated sodium reabsorption, Calcium signaling pathway, Chagas disease, Chemical carcinogenesis - receptor activation, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dilated cardiomyopathy, Gap junction, Hypertrophic cardiomyopathy, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Renin-angiotensin system, Salivary secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
540	STI571	-	-	-	-	[2] 51, 86
541	Subcutaneous and intravenous prostacyclin	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
542	Subcutaneous Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
543	Sugar pill	-	-	-	-	[8] 5, 6, 49, 67, 70, 86, 206, 210
544	SULFASALAZINE	[1] Sulfasalazine	[1] D00448	-	-	[6] 46, 86, 94, 107, 270, 271
545	Sulfate	[1] Sulfate ion	-	-	-	[27] 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 85, 86, 96, 111, 218, 222, 224, 226, 265, 296, 297, 299
546	Tadalafil	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[7] 6, 51, 75, 84, 86, 113, 210
547	Tadalafil 20 mg film-coated tablets	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
548	Tadalafil 40 mg	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
549	Tadalafil and ambrisentan upfront combination therapy	[2] Ambrisentan, Tadalafil	[2] D02008 , D07077	[2] EDNRA, PDE5A 💬	[9] Calcium signaling pathway, Metabolic pathways, Neuroactive ligand-receptor interaction, Pathways in cancer, Purine metabolism, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 51, 86
550	Tadalafil oral suspension	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
551	Tadalafil- Tablet or Oral suspension	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
552	TADALAFILO	[1] Tadalafil	[1] D02008	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[1] 86
553	Tasigna	[1] Nilotinib	[1] D08953	[4] ABL1, KIT, PDGFRA, PDGFRB 💬	[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[2] 34, 86
554	Tasigna®	[1] Nilotinib	[1] D08953	[4] ABL1, KIT, PDGFRA, PDGFRB 💬	[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
555	Tasigna® 150 mg	[1] Nilotinib	[1] D08953	[4] ABL1, KIT, PDGFRA, PDGFRB 💬	[33] Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬	[1] 86
556	TBD	-	-	-	-	[5] 19, 86, 90, 276, 299
557	Tegaderm	-	-	-	-	[1] 86
558	Terguride	[1] Terguride	[1] D01348	[2] DRD2, PRL 💬	[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬	[2] 51, 86
559	Terguride 0,5mg tablet	[1] Terguride	[1] D01348	[2] DRD2, PRL 💬	[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬	[1] 86
560	Terguride 0.5 mg tablet	[1] Terguride	[1] D01348	[2] DRD2, PRL 💬	[12] Alcoholism, Cocaine addiction, Cytokine-cytokine receptor interaction, Dopaminergic synapse, Gap junction, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, Parkinson disease, Prolactin signaling pathway, Rap1 signaling pathway, cAMP signaling pathway 💬	[1] 86
561	Tezosentan	[1] Tezosentan	-	-	-	[1] 86
562	The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:	-	-	-	-	[1] 86
563	The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:	-	-	-	-	[1] 86
564	Thelin	[1] Sitaxentan	[1] D07171	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
565	Threonine	[1] Threonine	[1] D00041	-	-	[2] 86, 97
566	Tocilizumab	[1] Tocilizumab	[1] D02596	[1] IL6R 💬	[12] Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, EGFR tyrosine kinase inhibitor resistance, HIF-1 signaling pathway, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, Non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, Pathways in cancer, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬	[21] 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
567	TOLVAPTAN	[1] Tolvaptan	[1] D01213	[1] AVPR2 💬	[3] Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬	[4] 67, 72, 86, 225
568	TPN171H	-	-	-	-	[1] 86
569	TPN171H single dose	-	-	-	-	[1] 86
570	Traclear	-	-	-	-	[1] 86
571	Tracleer	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[8] 13, 51, 84, 85, 86, 88, 210, 211
572	TRACLEER 62,5 mg comprimidos recubiertos con película	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
573	TRACLEER 62,5MG 56CPR RIV.	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
574	TRACLEER*125MG 56CPR RIV.	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[2] 51, 86
575	TRACLEER*56CPR RIV 125MG	[1] Bosentan	[2] D01227 , D07538	[2] EDNRA, EDNRB 💬	[9] Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[3] 51, 86, 88
576	Tracleer®	-	-	-	-	[1] 86
577	Transdihydrolisuride	-	-	-	-	[2] 51, 86
578	TRE	-	-	-	-	[1] 86
579	Treprosinil Diethanolamine	-	-	-	-	[1] 86
580	Treprostin	-	-	-	-	[1] 86
581	Treprostinil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[6] 51, 84, 85, 86, 88, 210
582	Treprostinil dietanolamina	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
583	Treprostinil diethanolamine	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[2] 51, 86
584	Treprostinil Diolamine	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
585	Treprostinil Inhalation Powder	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
586	Treprostinil inhalations	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
587	Treprostinil Injectable Product	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
588	Treprostinil Palmitil	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
589	TREPROSTINIL SODIUM	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[3] 51, 86, 88
590	Treprostinil Sodium Solution for Inhalation	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
591	TREPROSTINIL SODIUM, UT-15	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
592	Treprostinil, UT-15, LRX-15, 15AU81, BW A15AU, U-62, 840	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
593	Treprostinilo	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
594	Trimetazidine	[1] Trimetazidine	[1] D08642	-	-	[3] 2, 58, 86
595	Trisuva(r)	-	-	-	-	[1] 86
596	TRK-100STP	-	-	-	-	[1] 86
597	Tyrosine	[1] Tyrosine	[1] D00022	-	-	[3] 6, 86, 111
598	Tyvaso	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
599	Tyvaso Inhalation Solution	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
600	Ubenimex	[1] Ubenimex	[1] D00087	[1] ANPEP 💬	[4] Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system 💬	[1] 86
601	Udenafil	[1] Udenafil	[1] D10027	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[2] 86, 210
602	UK 092480	-	-	-	-	[1] 86
603	UK-92,480	-	-	-	-	[1] 86
604	UK-92,480-10	-	-	-	-	[1] 86
605	ULARITIDE	[1] Ularitide	-	-	-	[1] 86
606	Uptravi	[1] Selexipag	[1] D09994	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[3] 84, 86, 88
607	Urodilatin	-	-	-	-	[1] 86
608	UT-15C	-	-	-	-	[1] 86
609	UT-15C (treprostinil diethanolamine)	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
610	UT-15C 0.25 mg	-	-	-	-	[1] 86
611	UT-15C 1 mg	-	-	-	-	[1] 86
612	UT-15C 5 mg	-	-	-	-	[1] 86
613	UT-15C LP	-	-	-	-	[1] 86
614	UT-15C SR	-	-	-	-	[2] 51, 86
615	UT-15C SR (treprostinil diethanolamine)	[1] Treprostinil	[1] D06213	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
616	UT-15C-SR	-	-	-	-	[2] 51, 86
617	Vardenafil	[1] Vardenafil	[1] D08668	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[3] 13, 86, 299
618	Vasomera (PB1046) Injection	-	-	-	-	[1] 86
619	Veletri	[1] Epoprostenol	[1] D00106	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
620	Ventavis	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
621	Ventavis (Iloprost, BAYQ6256)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
622	Ventavis 10	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
623	Ventavis(Iloprost)	[1] Iloprost	[1] D02721	[1] PTGIR 💬	[3] Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬	[1] 86
624	VIAGRA	[1] Sildenafil	[1] D08514	[1] PDE5A 💬	[3] Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬	[3] 86, 96, 225
625	VIP	-	-	-	-	[3] 49, 51, 86
626	Volibris	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[4] 51, 85, 86, 88
627	VOLIBRIS 10 mg comprimidos recubiertos con película	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
628	VOLIBRIS 5 mg comprimidos recubiertos con película	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
629	VOLIBRIS® (ambrisentan)	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
630	VOLIBRIS™ tablets	[1] Ambrisentan	[1] D07077	[1] EDNRA 💬	[7] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬	[1] 86
631	Warfarin	[1] Warfarin	[1] D08682	[2] NQO1, VKORC1 💬	[7] Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬	[11] 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91
632	ZAMICASTAT	[1] Zamicastat	-	-	-	[1] 86