Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 IFNG [6] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D04242 Fontolizumab [1] 46
2 IFNG [6] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D11120 Emapalumab [3] 49, 65, 107
3 SMAD7 [1] TGF-beta signaling pathway D10956 Mongersen [2] 96, 97
4 RGMA [1] TGF-beta signaling pathway D11355 Elezanumab [1] 13
5 ROCK1 [4] Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
6 TGFB1 [4] TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis D09620 Fresolimumab [3] 51, 85, 222
7 TGFB2 [3] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis D09620 Fresolimumab [3] 51, 85, 222
8 TGFB3 [3] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis D09620 Fresolimumab [3] 51, 85, 222
9 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
10 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
11 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
12 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
13 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
14 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
15 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
16 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
17 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D05393 Pegsunercept [1] 46
18 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
19 TNF [9] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D09944 Ozoralizumab [1] 46
20 ACVR2A [1] TGF-beta signaling pathway D09670 Sotatercept [2] 86, 284
21 ACVR2A [1] TGF-beta signaling pathway D10620 Bimagrumab [1] 15
22 ACVR2B [1] TGF-beta signaling pathway D10620 Bimagrumab [1] 15
23 ACVR2B [1] TGF-beta signaling pathway D11701 Luspatercept [1] 60