Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Type II diabetes mellitus 💬
 [2] ABCC8, KCNJ11 💬 D00294 💬 Diazoxide [2] 13, 193 💬
2 Type II diabetes mellitus 💬
 [2] ABCC8, KCNJ11 💬 D00418 💬 Minoxidil [1] 179 💬
3 Type II diabetes mellitus 💬
 [2] ABCC8, KCNJ11 💬 D00594 💬 Repaglinide [4]  6 , 21, 46, 299 💬
4 Type II diabetes mellitus 💬
 [3] CACNA1B, CACNA1C, CACNA1D 💬 D01173 💬 Cilnidipine [1] 67 💬
5 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
6 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
7 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D00349 💬 Isradipine [1]  6  💬
8 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D08270 💬 Nicardipine [2] 70, 86 💬
9 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D00437 💬 Nifedipine [2] 50, 81 💬
10 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D01908 💬 Nilvadipine [1] 90 💬
11 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D08340 💬 Perhexiline [2] 58, 272 💬
12 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D08441 💬 Propiverine [1] 226 💬
13 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
14 Type II diabetes mellitus 💬
 [2] CACNA1C, CACNA1D 💬 D02356 💬 Verapamil [4] 58, 96, 140, 167 💬
15 Type II diabetes mellitus 💬
 [1] CACNA1G 💬 D07971 💬 Flunarizine [1] 149 💬
16 Type II diabetes mellitus 💬
 [1] CACNA1G 💬 D00399 💬 Valproic acid [14]  2 ,  3 ,  5 ,  6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬
17 Type II diabetes mellitus 💬
 [1] CACNA1G 💬 D00538 💬 Zonisamide [1]  6  💬
18 Type II diabetes mellitus 💬
 [1] INSR 💬 D04539 💬 Insulin detemir [1] 299 💬
19 Type II diabetes mellitus 💬
 [1] INSR 💬 D03250 💬 Insulin glargine [1] 299 💬
20 Type II diabetes mellitus 💬
 [1] INSR 💬 D03230 💬 Insulin human [2] 96, 156 💬
21 Type II diabetes mellitus 💬
 [1] KCNJ11 💬 D02910 💬 Amiodarone [2] 28, 127 💬
22 Type II diabetes mellitus 💬
 [1] MTOR 💬 D02714 💬 Everolimus [9] 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
23 Type II diabetes mellitus 💬
 [1] MTOR 💬 D00753 💬 Sirolimus [40]  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
24 Type II diabetes mellitus 💬
 [1] MTOR 💬 D06068 💬 Temsirolimus [1] 13 💬
25 Type II diabetes mellitus 💬
 [1] PIK3CA 💬 D11011 💬 Alpelisib [1] 138 💬
26 Type II diabetes mellitus 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
27 Type II diabetes mellitus 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
28 Type II diabetes mellitus 💬
 [2] PRKCD, PRKCE 💬 D09671 💬 Sotrastaurin [1] 97 💬
29 Type II diabetes mellitus 💬
 [1] TNF 💬 D02597 💬 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271 💬
30 Type II diabetes mellitus 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
31 Type II diabetes mellitus 💬
 [1] TNF 💬 D00742 💬 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285 💬
32 Type II diabetes mellitus 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
33 Type II diabetes mellitus 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
34 Type II diabetes mellitus 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
35 Type II diabetes mellitus 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
36 Type II diabetes mellitus 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
37 Type II diabetes mellitus 💬
 [1] TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
38 Type II diabetes mellitus 💬
 [1] TNF 💬 D08976 💬 Pomalidomide [5] 28, 51, 85, 227, 331 💬
39 Type II diabetes mellitus 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬