Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 MAPK14 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
2 MAPK14 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
3 IFNA1 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
4 IFNA1 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
5 IFNA2 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
6 IFNA2 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
7 IFNA4 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
8 IFNA4 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
9 IFNA5 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
10 IFNA5 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
11 IFNA6 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
12 IFNA6 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
13 IFNA7 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
14 IFNA7 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
15 IFNA8 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
16 IFNA8 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
17 IFNA10 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
18 IFNA10 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
19 IFNA13 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
20 IFNA13 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
21 IFNA14 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
22 IFNA14 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
23 IFNA16 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
24 IFNA16 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
25 IFNA17 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
26 IFNA17 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
27 IFNA21 [2] Toll-like receptor signaling pathway, Tuberculosis D09662 Rontalizumab [1] 49
28 IFNA21 [2] Toll-like receptor signaling pathway, Tuberculosis D09668 Sifalimumab [1] 49
29 IFNAR1 [1] Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
30 IFNAR1 [1] Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
31 IFNAR1 [1] Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
32 IFNAR1 [1] Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
33 IFNAR1 [1] Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
34 IFNAR1 [1] Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
35 IFNAR1 [1] Toll-like receptor signaling pathway D11082 Anifrolumab [3] 46, 49, 53
36 IFNAR2 [1] Toll-like receptor signaling pathway D00745 Interferon alfa-2a [1] 56
37 IFNAR2 [1] Toll-like receptor signaling pathway D00746 Interferon beta-1b [1] 13
38 IFNAR2 [1] Toll-like receptor signaling pathway D02745 Interferon alfa-2b [2] 25, 34
39 IFNAR2 [1] Toll-like receptor signaling pathway D03305 Interferon alfa [6] 13, 25, 26, 28, 56, 96
40 IFNAR2 [1] Toll-like receptor signaling pathway D04554 Interferon beta-1a [4] 13, 26, 96, 97
41 IFNAR2 [1] Toll-like receptor signaling pathway D10483 Peginterferon beta-1a [1] 13
42 IFNAR2 [1] Toll-like receptor signaling pathway D11082 Anifrolumab [3] 46, 49, 53
43 IL1B [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
44 IL1B [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D06635 Rilonacept [4] 51, 106, 107, 266
45 IL1B [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
46 IL1B [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Yersinia infection, Tuberculosis D09911 Gevokizumab [4] 41, 50, 56, 269
47 IL6 [5] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
48 IL6 [5] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D08976 Pomalidomide [5] 28, 51, 85, 227, 331
49 IL6 [5] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D09669 Siltuximab [2] 28, 331
50 IL6 [5] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D10080 Sirukumab [2] 41, 46
51 IL6 [5] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer D12487 Olokizumab [2] 46, 96
52 IL12A [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
53 IL12B [4] Toll-like receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis D09214 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
54 NFKB1 [6] Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod [5] 46, 51, 53, 271, 300
55 TLR7 [1] Toll-like receptor signaling pathway D02500 Imiquimod [2] 34, 51
56 PIK3CA [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11011 Alpelisib [1] 138
57 PIK3CA [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
58 PIK3CB [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
59 PIK3CD [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
60 PIK3CD [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Type II diabetes mellitus, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib [3] 35, 53, 61
61 TLR9 [2] Toll-like receptor signaling pathway, Tuberculosis D12275 Cobitolimod [1] 97
62 MAPK11 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
63 MAPK11 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
64 MAPK13 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
65 MAPK13 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
66 MAP2K1 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D09666 Selumetinib [1] 34
67 MAP2K1 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10175 Trametinib [4] 2, 34, 279, 280
68 MAP2K1 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10405 Cobimetinib [1] 280
69 MAP2K1 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10604 Binimetinib [1] 34
70 MAP2K1 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D11675 Mirdametinib [1] 34
71 MAP2K2 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D09666 Selumetinib [1] 34
72 MAP2K2 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10175 Trametinib [4] 2, 34, 279, 280
73 MAP2K2 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10405 Cobimetinib [1] 280
74 MAP2K2 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D10604 Binimetinib [1] 34
75 MAP2K2 [4] Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection D11675 Mirdametinib [1] 34
76 RELA [6] Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent [1] 113
77 MAPK12 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
78 MAPK12 [5] VEGF signaling pathway, Toll-like receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
79 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
80 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
81 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
82 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
83 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
84 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
85 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
86 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
87 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D05393 Pegsunercept [1] 46
88 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
89 TNF [7] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis D09944 Ozoralizumab [1] 46
90 CD80 [4] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
91 CD80 [4] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Viral myocarditis D03222 Belatacept [1] 46
92 CD86 [5] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
93 CD86 [5] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Viral myocarditis D03222 Belatacept [1] 46
94 CD40 [4] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11357 Bleselumab [1] 222
95 CD40 [4] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11597 Ravagalimab [2] 53, 97
96 CD40 [4] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Viral myocarditis D11610 Iscalimab [2] 49, 53