Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ELANE [2] Transcriptional misregulation in cancer, Systemic lupus erythematosus D03788 Sivelestat [3] 13, 85, 96
2 GRIN2A [1] Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
3 GRIN2A [1] Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
4 GRIN2A [1] Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
5 GRIN2A [1] Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
6 GRIN2A [1] Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
7 GRIN2A [1] Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
8 GRIN2A [1] Systemic lupus erythematosus D08174 Memantine [8] 2, 6, 8, 13, 49, 127, 205, 206
9 GRIN2A [1] Systemic lupus erythematosus D09917 Latrepirdine [1] 8
10 GRIN2B [1] Systemic lupus erythematosus D00775 Riluzole [9] 2, 3, 5, 8, 13, 17, 18, 203, 206
11 GRIN2B [1] Systemic lupus erythematosus D03742 Dextromethorphan [11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
12 GRIN2B [1] Systemic lupus erythematosus D07058 Acamprosate [2] 6, 206
13 GRIN2B [1] Systemic lupus erythematosus D07283 Esketamine [3] 2, 4, 70
14 GRIN2B [1] Systemic lupus erythematosus D07441 Amantadine [4] 6, 8, 13, 127
15 GRIN2B [1] Systemic lupus erythematosus D08098 Ketamine [8] 2, 4, 6, 13, 70, 113, 156, 215
16 GRIN2B [1] Systemic lupus erythematosus D08174 Memantine [8] 2, 6, 8, 13, 49, 127, 205, 206
17 GRIN2B [1] Systemic lupus erythematosus D09917 Latrepirdine [1] 8
18 IFNG [8] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04242 Fontolizumab [1] 46
19 IFNG [8] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D11120 Emapalumab [3] 49, 65, 107
20 IL10 [6] Viral protein interaction with cytokine and cytokine receptor, T cell receptor signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
21 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
22 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
23 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
24 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
25 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
26 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
27 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
28 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
29 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D05393 Pegsunercept [1] 46
30 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D08976 Pomalidomide [5] 28, 51, 85, 227, 331
31 TNF [11] Viral protein interaction with cytokine and cytokine receptor, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D09944 Ozoralizumab [1] 46
32 C1R [1] Systemic lupus erythematosus D10845 Conestat alfa [1] 61
33 C1S [1] Systemic lupus erythematosus D10845 Conestat alfa [1] 61
34 C1S [1] Systemic lupus erythematosus D11530 Sutimlimab [1] 61
35 C3 [3] Tuberculosis, Viral carcinogenesis, Systemic lupus erythematosus D11613 Pegcetacoplan [4] 2, 61, 62, 222
36 C5 [1] Systemic lupus erythematosus D03940 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222
37 C5 [1] Systemic lupus erythematosus D11054 Ravulizumab [7] 2, 11, 13, 50, 62, 66, 109
38 C5 [1] Systemic lupus erythematosus D11473 Nomacopan [3] 62, 109, 162
39 C5 [1] Systemic lupus erythematosus D11477 Pozelimab [2] 11, 62
40 C5 [1] Systemic lupus erythematosus D11696 Crovalimab [2] 62, 109
41 C5 [1] Systemic lupus erythematosus D11838 Vilobelimab [3] 43, 44, 269
42 C5 [1] Systemic lupus erythematosus D12357 Zilucoplan [3] 2, 11, 62
43 CD80 [5] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Systemic lupus erythematosus, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
44 CD80 [5] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Systemic lupus erythematosus, Viral myocarditis D03222 Belatacept [1] 46
45 CD86 [6] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
46 CD86 [6] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Viral myocarditis D03222 Belatacept [1] 46
47 CD40 [5] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Viral myocarditis D11357 Bleselumab [1] 222
48 CD40 [5] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Viral myocarditis D11597 Ravagalimab [2] 53, 97
49 CD40 [5] Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Viral myocarditis D11610 Iscalimab [2] 49, 53
50 CD40LG [4] T cell receptor signaling pathway, Toxoplasmosis, Systemic lupus erythematosus, Viral myocarditis D06193 Toralizumab [1] 63