Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 TNFSF13B [1] Rheumatoid arthritis D03068 Belimumab [13] 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300
2 TNFSF13B [1] Rheumatoid arthritis D09704 Atacicept [4] 13, 46, 49, 66
3 TNFSF13B [1] Rheumatoid arthritis D10083 Tabalumab [2] 46, 49
4 TNFSF13B [1] Rheumatoid arthritis D11127 Tibulizumab [1] 53
5 CSF2 [5] T cell receptor signaling pathway, TNF signaling pathway, Shigellosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D11343 Otilimab [1] 46
6 CTLA4 [2] T cell receptor signaling pathway, Rheumatoid arthritis D04603 Ipilimumab [1] 159
7 CTLA4 [2] T cell receptor signaling pathway, Rheumatoid arthritis D06657 Tremelimumab [1] 96
8 FLT1 [2] Transcriptional misregulation in cancer, Rheumatoid arthritis D03218 Axitinib [1] 34
9 FLT1 [2] Transcriptional misregulation in cancer, Rheumatoid arthritis D08552 Sunitinib [2] 28, 34
10 FLT1 [2] Transcriptional misregulation in cancer, Rheumatoid arthritis D08881 Cediranib [1] 34
11 FLT1 [2] Transcriptional misregulation in cancer, Rheumatoid arthritis D10481 Nintedanib [5] 51, 85, 89, 227, 228
12 IFNG [9] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D04242 Fontolizumab [1] 46
13 IFNG [9] TGF-beta signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Type I diabetes mellitus, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D11120 Emapalumab [3] 49, 65, 107
14 IL1A [3] Type I diabetes mellitus, Tuberculosis, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
15 IL1A [3] Type I diabetes mellitus, Tuberculosis, Rheumatoid arthritis D06635 Rilonacept [4] 51, 106, 107, 266
16 IL1A [3] Type I diabetes mellitus, Tuberculosis, Rheumatoid arthritis D11253 Bermekimab [1] 51
17 IL1B [9] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Tuberculosis, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
18 IL1B [9] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Tuberculosis, Rheumatoid arthritis D06635 Rilonacept [4] 51, 106, 107, 266
19 IL1B [9] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Tuberculosis, Rheumatoid arthritis D09315 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
20 IL1B [9] Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Tuberculosis, Rheumatoid arthritis D09911 Gevokizumab [4] 41, 50, 56, 269
21 IL6 [9] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
22 IL6 [9] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
23 IL6 [9] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D09669 Siltuximab [2] 28, 331
24 IL6 [9] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D10080 Sirukumab [2] 41, 46
25 IL6 [9] Viral protein interaction with cytokine and cytokine receptor, Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Salmonella infection, Yersinia infection, Tuberculosis, Transcriptional misregulation in cancer, Rheumatoid arthritis D12487 Olokizumab [2] 46, 96
26 IL17A [2] Th17 cell differentiation, Rheumatoid arthritis D09967 Secukinumab [8] 13, 37, 41, 46, 107, 160, 269, 271
27 IL17A [2] Th17 cell differentiation, Rheumatoid arthritis D10071 Ixekizumab [8] 36, 37, 46, 107, 160, 162, 269, 271
28 IL17A [2] Th17 cell differentiation, Rheumatoid arthritis D11127 Tibulizumab [1] 53
29 IL17A [2] Th17 cell differentiation, Rheumatoid arthritis D11550 Bimekizumab [3] 46, 97, 271
30 ITGAL [3] Staphylococcus aureus infection, Rheumatoid arthritis, Viral myocarditis D03959 Efalizumab [9] 11, 13, 37, 46, 49, 53, 61, 95, 96
31 LTB [1] Rheumatoid arthritis D08866 Baminercept [4] 13, 46, 53, 97
32 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D09214 Ustekinumab [16] 37, 40, 41, 46, 49, 50, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
33 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D10400 Tildrakizumab [2] 162, 271
34 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D10438 Guselkumab [5] 37, 41, 51, 96, 97
35 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D10912 Brazikumab [2] 96, 97
36 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D11052 Risankizumab [4] 37, 96, 97, 271
37 IL23A [3] Th17 cell differentiation, Tuberculosis, Rheumatoid arthritis D11123 Mirikizumab [3] 37, 96, 97
38 CCL2 [4] Viral protein interaction with cytokine and cytokine receptor, TNF signaling pathway, Yersinia infection, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
39 TGFB1 [5] TGF-beta signaling pathway, Th17 cell differentiation, Toxoplasmosis, Tuberculosis, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
40 TGFB2 [4] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
41 TGFB3 [4] TGF-beta signaling pathway, Toxoplasmosis, Tuberculosis, Rheumatoid arthritis D09620 Fresolimumab [3] 51, 85, 222
42 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
43 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
44 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
45 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
46 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
47 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
48 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
49 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
50 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D05393 Pegsunercept [1] 46
51 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D08976 Pomalidomide [5] 28, 51, 85, 227, 331
52 TNF [16] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus, Rheumatoid arthritis D09944 Ozoralizumab [1] 46
53 VEGFA [2] VEGF signaling pathway, Rheumatoid arthritis D05697 Ranibizumab [4] 34, 166, 227, 301
54 VEGFA [2] VEGF signaling pathway, Rheumatoid arthritis D06409 Bevacizumab [6] 13, 34, 85, 87, 227, 280
55 VEGFA [2] VEGF signaling pathway, Rheumatoid arthritis D09574 Aflibercept [2] 90, 166
56 TNFSF11 [1] Rheumatoid arthritis D03684 Denosumab [8] 46, 50, 70, 93, 95, 96, 274, 299
57 TNFSF13 [1] Rheumatoid arthritis D09704 Atacicept [4] 13, 46, 49, 66
58 CD80 [6] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Systemic lupus erythematosus, Rheumatoid arthritis, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
59 CD80 [6] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Systemic lupus erythematosus, Rheumatoid arthritis, Viral myocarditis D03222 Belatacept [1] 46
60 CD86 [7] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Rheumatoid arthritis, Viral myocarditis D03203 Abatacept [26] 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
61 CD86 [7] Virion - Adenovirus, Toll-like receptor signaling pathway, Type I diabetes mellitus, Transcriptional misregulation in cancer, Systemic lupus erythematosus, Rheumatoid arthritis, Viral myocarditis D03222 Belatacept [1] 46