Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholic liver disease 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
2 Aldosterone synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
3 Calcium signaling pathway 💬
 [1] HRH1 💬 D07398 💬 Chlorpheniramine [1] 14 💬
4 cAMP signaling pathway 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
5 Complement and coagulation cascades 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
6 Coronavirus disease - COVID-19 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
7 Cortisol synthesis and secretion 💬
 [1] KCNA4 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
8 Cortisol synthesis and secretion 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
9 Cushing syndrome 💬
 [1] KCNA4 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
10 Cushing syndrome 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
11 FoxO signaling pathway 💬
 [1] S1PR1 💬 D10001 💬 Fingolimod [3] 13, 14, 156 💬
12 Hematopoietic cell lineage 💬
 [1] MS4A1 💬 D02994 💬 Rituximab [48] 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
13 Herpes simplex virus 1 infection 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
14 Inflammatory mediator regulation of TRP channels 💬
 [1] HRH1 💬 D07398 💬 Chlorpheniramine [1] 14 💬
15 Neuroactive ligand-receptor interaction 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
16 Neuroactive ligand-receptor interaction 💬
 [1] HRH1 💬 D07398 💬 Chlorpheniramine [1] 14 💬
17 Neuroactive ligand-receptor interaction 💬
 [1] MC2R 💬 D00146 💬 Corticotropin [12]  2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬
18 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00292 💬 Dexamethasone [22] 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬
19 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00407 💬 Methylprednisolone [46]  2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
20 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00472 💬 Prednisolone [42]  3 , 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
21 Neuroactive ligand-receptor interaction 💬
 [1] NR3C1 💬 D00473 💬 Prednisone [45]  2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
22 Neuroactive ligand-receptor interaction 💬
 [1] S1PR1 💬 D10001 💬 Fingolimod [3] 13, 14, 156 💬
23 Neutrophil extracellular trap formation 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
24 Pertussis 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
25 Platinum drug resistance 💬
 [2] TOP2A, TOP2B 💬 D00125 💬 Etoposide [11] 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 💬
26 Prion disease 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
27 Regulation of actin cytoskeleton 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
28 Serotonergic synapse 💬
 [1] KCND2 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
29 Sphingolipid signaling pathway 💬
 [1] S1PR1 💬 D10001 💬 Fingolimod [3] 13, 14, 156 💬
30 Spinocerebellar ataxia 💬
 [2] KCNC3, KCND3 💬 D04127 💬 Dalfampridine [5]  3 ,  4 ,  6 , 13, 14 💬
31 Staphylococcus aureus infection 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬
32 Systemic lupus erythematosus 💬
 [1] C5 💬 D03940 💬 Eculizumab [7] 11, 13, 14, 61, 62, 109, 222 💬

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