Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Alcoholism 💬
 [1] ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
2 Alcoholism 💬
 [1] ADORA2B 💬 D00371 💬 Theophylline [2] 236, 299 💬
3 Alcoholism 💬
 [1] ADORA2B 💬 D01712 💬 Theophylline [2] 236, 299 💬
4 Alcoholism 💬
 [1] ADORA2B 💬 D06103 💬 Theophylline [2] 236, 299 💬
5 Alcoholism 💬
 [1] ADORA2B 💬 D06104 💬 Theophylline [2] 236, 299 💬
6 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D00371 💬 Theophylline [2] 236, 299 💬
7 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D01712 💬 Theophylline [2] 236, 299 💬
8 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
9 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D06103 💬 Theophylline [2] 236, 299 💬
10 Aldosterone synthesis and secretion 💬
 [1] PDE2A 💬 D06104 💬 Theophylline [2] 236, 299 💬
11 Apelin signaling pathway 💬
 [1] PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
12 Apelin signaling pathway 💬
 [1] PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
13 Apelin signaling pathway 💬
 [1] PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
14 Apelin signaling pathway 💬
 [1] PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
15 Apelin signaling pathway 💬
 [1] PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
16 Calcium signaling pathway 💬
 [4] ADORA2A, PDE1A, PDE1B, PDE1C 💬 D02017 💬 Theophylline [2] 236, 299 💬
17 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D00371 💬 Theophylline [2] 236, 299 💬
18 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D01712 💬 Theophylline [2] 236, 299 💬
19 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D06103 💬 Theophylline [2] 236, 299 💬
20 Calcium signaling pathway 💬
 [4] ADORA2B, PDE1A, PDE1B, PDE1C 💬 D06104 💬 Theophylline [2] 236, 299 💬
21 cAMP signaling pathway 💬
 [9] ADORA1, ADORA2A, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D02017 💬 Theophylline [2] 236, 299 💬
22 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D00371 💬 Theophylline [2] 236, 299 💬
23 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D01712 💬 Theophylline [2] 236, 299 💬
24 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D06103 💬 Theophylline [2] 236, 299 💬
25 cAMP signaling pathway 💬
 [8] ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D06104 💬 Theophylline [2] 236, 299 💬
26 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
27 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
28 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
29 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
30 cGMP-PKG signaling pathway 💬
 [4] ADORA1, PDE2A, PDE3A, PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
31 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D00371 💬 Theophylline [2] 236, 299 💬
32 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D01712 💬 Theophylline [2] 236, 299 💬
33 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D02017 💬 Theophylline [2] 236, 299 💬
34 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D06103 💬 Theophylline [2] 236, 299 💬
35 Cortisol synthesis and secretion 💬
 [2] PDE8A, PDE8B 💬 D06104 💬 Theophylline [2] 236, 299 💬
36 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D00371 💬 Theophylline [2] 236, 299 💬
37 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D01712 💬 Theophylline [2] 236, 299 💬
38 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D02017 💬 Theophylline [2] 236, 299 💬
39 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D06103 💬 Theophylline [2] 236, 299 💬
40 Cushing syndrome 💬
 [3] PDE11A, PDE8A, PDE8B 💬 D06104 💬 Theophylline [2] 236, 299 💬
41 Cytokine-cytokine receptor interaction 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
42 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
43 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
44 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
45 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
46 Glucagon signaling pathway 💬
 [1] PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
47 Growth hormone synthesis, secretion and action 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
48 Insulin signaling pathway 💬
 [1] PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
49 Insulin signaling pathway 💬
 [1] PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
50 Insulin signaling pathway 💬
 [1] PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
51 Insulin signaling pathway 💬
 [1] PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
52 Insulin signaling pathway 💬
 [1] PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
53 JAK-STAT signaling pathway 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
54 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00371 💬 Theophylline [2] 236, 299 💬
55 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D01712 💬 Theophylline [2] 236, 299 💬
56 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D02017 💬 Theophylline [2] 236, 299 💬
57 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06103 💬 Theophylline [2] 236, 299 💬
58 Metabolic pathways 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06104 💬 Theophylline [2] 236, 299 💬
59 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00371 💬 Theophylline [2] 236, 299 💬
60 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D01712 💬 Theophylline [2] 236, 299 💬
61 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D02017 💬 Theophylline [2] 236, 299 💬
62 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06103 💬 Theophylline [2] 236, 299 💬
63 Morphine addiction 💬
 [17] ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06104 💬 Theophylline [2] 236, 299 💬
64 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
65 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D00371 💬 Theophylline [2] 236, 299 💬
66 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D01712 💬 Theophylline [2] 236, 299 💬
67 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D06103 💬 Theophylline [2] 236, 299 💬
68 Neuroactive ligand-receptor interaction 💬
 [2] ADORA1, ADORA2B 💬 D06104 💬 Theophylline [2] 236, 299 💬
69 Neuroactive ligand-receptor interaction 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
70 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D00371 💬 Theophylline [2] 236, 299 💬
71 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D01712 💬 Theophylline [2] 236, 299 💬
72 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
73 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D06103 💬 Theophylline [2] 236, 299 💬
74 Olfactory transduction 💬
 [4] PDE1A, PDE1B, PDE1C, PDE2A 💬 D06104 💬 Theophylline [2] 236, 299 💬
75 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D00371 💬 Theophylline [2] 236, 299 💬
76 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D01712 💬 Theophylline [2] 236, 299 💬
77 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D02017 💬 Theophylline [2] 236, 299 💬
78 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D06103 💬 Theophylline [2] 236, 299 💬
79 Parathyroid hormone synthesis, secretion and action 💬
 [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 D06104 💬 Theophylline [2] 236, 299 💬
80 Parkinson disease 💬
 [1] ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
81 PI3K-Akt signaling pathway 💬
 [1] GHR 💬 D02691 💬 Somatotropin [23]  2 ,  3 , 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299 💬
82 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
83 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
84 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
85 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
86 Progesterone-mediated oocyte maturation 💬
 [1] PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
87 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00371 💬 Theophylline [2] 236, 299 💬
88 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D01712 💬 Theophylline [2] 236, 299 💬
89 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D02017 💬 Theophylline [2] 236, 299 💬
90 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06103 💬 Theophylline [2] 236, 299 💬
91 Purine metabolism 💬
 [16] PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06104 💬 Theophylline [2] 236, 299 💬
92 Rap1 signaling pathway 💬
 [1] ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
93 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D00371 💬 Theophylline [2] 236, 299 💬
94 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D01712 💬 Theophylline [2] 236, 299 💬
95 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D06103 💬 Theophylline [2] 236, 299 💬
96 Rap1 signaling pathway 💬
 [1] ADORA2B 💬 D06104 💬 Theophylline [2] 236, 299 💬
97 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
98 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
99 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
100 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
101 Regulation of lipolysis in adipocytes 💬
 [2] ADORA1, PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
102 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D00371 💬 Theophylline [2] 236, 299 💬
103 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D01712 💬 Theophylline [2] 236, 299 💬
104 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D02017 💬 Theophylline [2] 236, 299 💬
105 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D06103 💬 Theophylline [2] 236, 299 💬
106 Renin secretion 💬
 [6] ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D06104 💬 Theophylline [2] 236, 299 💬
107 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D00371 💬 Theophylline [2] 236, 299 💬
108 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D01712 💬 Theophylline [2] 236, 299 💬
109 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D02017 💬 Theophylline [2] 236, 299 💬
110 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D06103 💬 Theophylline [2] 236, 299 💬
111 Sphingolipid signaling pathway 💬
 [1] ADORA1 💬 D06104 💬 Theophylline [2] 236, 299 💬
112 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D00371 💬 Theophylline [2] 236, 299 💬
113 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D01712 💬 Theophylline [2] 236, 299 💬
114 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D02017 💬 Theophylline [2] 236, 299 💬
115 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D06103 💬 Theophylline [2] 236, 299 💬
116 Taste transduction 💬
 [3] PDE1A, PDE1B, PDE1C 💬 D06104 💬 Theophylline [2] 236, 299 💬
117 Vascular smooth muscle contraction 💬
 [1] ADORA2A 💬 D02017 💬 Theophylline [2] 236, 299 💬
118 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D00371 💬 Theophylline [2] 236, 299 💬
119 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D01712 💬 Theophylline [2] 236, 299 💬
120 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D06103 💬 Theophylline [2] 236, 299 💬
121 Vascular smooth muscle contraction 💬
 [1] ADORA2B 💬 D06104 💬 Theophylline [2] 236, 299 💬

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