Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Dopaminergic synapse 💬
 [3] CACNA1B, CACNA1C, CACNA1D 💬 D01173 💬 Cilnidipine [1] 67 💬
2 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00615 💬 Amlodipine [4] 13, 51, 67, 298 💬
3 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D02914 💬 Amlodipine [4] 13, 51, 67, 298 💬
4 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D07450 💬 Amlodipine [4] 13, 51, 67, 298 💬
5 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00616 💬 Diltiazem [3] 51, 58, 86 💬
6 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D03830 💬 Diltiazem [3] 51, 58, 86 💬
7 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D07845 💬 Diltiazem [3] 51, 58, 86 💬
8 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00349 💬 Isradipine [1]  6  💬
9 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00617 💬 Nicardipine [2] 70, 86 💬
10 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08270 💬 Nicardipine [2] 70, 86 💬
11 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00437 💬 Nifedipine [2] 50, 81 💬
12 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D01908 💬 Nilvadipine [1] 90 💬
13 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D05442 💬 Perhexiline [2] 58, 272 💬
14 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08340 💬 Perhexiline [2] 58, 272 💬
15 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D08441 💬 Propiverine [1] 226 💬
16 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D00619 💬 Verapamil [3] 96, 140, 167 💬
17 Dopaminergic synapse 💬
 [2] CACNA1C, CACNA1D 💬 D02356 💬 Verapamil [3] 96, 140, 167 💬
18 Dopaminergic synapse 💬
 [7] CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 D00537 💬 Topiramate [6]  6 , 97, 140, 144, 156, 193 💬
19 Dopaminergic synapse 💬
 [1] COMT 💬 D00781 💬 Entacapone [2]  6 , 17 💬
20 Dopaminergic synapse 💬
 [1] COMT 💬 D10825 💬 Opicapone [1]  6  💬
21 Dopaminergic synapse 💬
 [1] COMT 💬 D00786 💬 Tolcapone [3]  6 , 28, 127 💬
22 Dopaminergic synapse 💬
 [1] DDC 💬 D03082 💬 Benserazide [1]  6  💬
23 Dopaminergic synapse 💬
 [1] DDC 💬 D00558 💬 Carbidopa [9]  2 ,  4 ,  6 , 13, 17, 90, 140, 164, 201 💬
24 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 D02004 💬 Apomorphine [3]  5 ,  6 ,  7  💬
25 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 D07460 💬 Apomorphine [3]  5 ,  6 ,  7  💬
26 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 D01044 💬 Flupentixol [1] 97 💬
27 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 D00502 💬 Pergolide [1]  6  💬
28 Dopaminergic synapse 💬
 [2] DRD1, DRD2 💬 D08339 💬 Pergolide [1]  6  💬
29 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D09886 💬 Dexpramipexole [1]  2  💬
30 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D00633 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
31 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D07870 💬 Dopamine [4]  6 ,  7 , 74, 299 💬
32 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D11839 💬 Foslevodopa [1]  6  💬
33 Dopaminergic synapse 💬
 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 D00059 💬 Levodopa [8]  2 ,  4 ,  6 , 17, 90, 140, 164, 201 💬
34 Dopaminergic synapse 💬
 [2] DRD1, DRD5 💬 D11431 💬 Tavapadon [1]  6  💬
35 Dopaminergic synapse 💬
 [1] DRD2 💬 D00780 💬 Bromocriptine [2]  6 , 74 💬
36 Dopaminergic synapse 💬
 [1] DRD2 💬 D03165 💬 Bromocriptine [2]  6 , 74 💬
37 Dopaminergic synapse 💬
 [1] DRD2 💬 D00702 💬 Buspirone [3]  6 , 51, 179 💬
38 Dopaminergic synapse 💬
 [1] DRD2 💬 D07593 💬 Buspirone [3]  6 , 51, 179 💬
39 Dopaminergic synapse 💬
 [1] DRD2 💬 D00987 💬 Cabergoline [3]  6 , 74, 75 💬
40 Dopaminergic synapse 💬
 [1] DRD2 💬 D09997 💬 Cariprazine [1] 21 💬
41 Dopaminergic synapse 💬
 [1] DRD2 💬 D00270 💬 Chlorpromazine [1] 254 💬
42 Dopaminergic synapse 💬
 [1] DRD2 💬 D00789 💬 Chlorpromazine [1] 254 💬
43 Dopaminergic synapse 💬
 [1] DRD2 💬 D03274 💬 Chlorpromazine [1] 254 💬
44 Dopaminergic synapse 💬
 [1] DRD2 💬 D04034 💬 Chlorpromazine [1] 254 💬
45 Dopaminergic synapse 💬
 [1] DRD2 💬 D01745 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
46 Dopaminergic synapse 💬
 [1] DRD2 💬 D07868 💬 Domperidone [5]  6 , 13, 17, 51, 230 💬
47 Dopaminergic synapse 💬
 [1] DRD2 💬 D00136 💬 Haloperidol [1]  8  💬
48 Dopaminergic synapse 💬
 [1] DRD2 💬 D01898 💬 Haloperidol [1]  8  💬
49 Dopaminergic synapse 💬
 [1] DRD2 💬 D07309 💬 Melperone [1]  6  💬
50 Dopaminergic synapse 💬
 [1] DRD2 💬 D00726 💬 Metoclopramide [1] 51 💬
51 Dopaminergic synapse 💬
 [1] DRD2 💬 D02213 💬 Metoclopramide [1] 51 💬
52 Dopaminergic synapse 💬
 [1] DRD2 💬 D05008 💬 Metoclopramide [1] 51 💬
53 Dopaminergic synapse 💬
 [1] DRD2 💬 D00560 💬 Pimozide [1]  2  💬
54 Dopaminergic synapse 💬
 [1] DRD2 💬 D09953 💬 Pridopidine [3]  2 ,  6 ,  8  💬
55 Dopaminergic synapse 💬
 [1] DRD2 💬 D00458 💬 Quetiapine [2]  6 , 13 💬
56 Dopaminergic synapse 💬
 [1] DRD2 💬 D08456 💬 Quetiapine [2]  6 , 13 💬
57 Dopaminergic synapse 💬
 [1] DRD2 💬 D00426 💬 Risperidone [5]  8 , 156, 179, 187, 206 💬
58 Dopaminergic synapse 💬
 [1] DRD2 💬 D05768 💬 Rotigotine [2]  6 , 127 💬
59 Dopaminergic synapse 💬
 [1] DRD2 💬 D01226 💬 Sulpiride [5]  2 ,  6 , 17, 46, 70 💬
60 Dopaminergic synapse 💬
 [1] DRD2 💬 D08549 💬 Sulpiride [5]  2 ,  6 , 17, 46, 70 💬
61 Dopaminergic synapse 💬
 [1] DRD2 💬 D01348 💬 Terguride [2] 51, 86 💬
62 Dopaminergic synapse 💬
 [1] DRD2 💬 D08590 💬 Tiapride [1]  8  💬
63 Dopaminergic synapse 💬
 [1] DRD2 💬 D00799 💬 Trifluoperazine [2] 283, 284 💬
64 Dopaminergic synapse 💬
 [1] DRD2 💬 D01448 💬 Trifluoperazine [2] 283, 284 💬
65 Dopaminergic synapse 💬
 [1] DRD2 💬 D08636 💬 Trifluoperazine [2] 283, 284 💬
66 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 D01164 💬 Aripiprazole [2]  6 , 206 💬
67 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 D09397 💬 Pardoprunox [1]  6  💬
68 Dopaminergic synapse 💬
 [2] DRD2, DRD3 💬 D07305 💬 Piribedil [1]  6  💬
69 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D01462 💬 Lisuride [2]  6 , 86 💬
70 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D08132 💬 Lisuride [2]  6 , 86 💬
71 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D00454 💬 Olanzapine [2]  2 ,  8  💬
72 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D06623 💬 Olanzapine [2]  2 ,  8  💬
73 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D00559 💬 Pramipexole [3]  2 ,  6 , 20 💬
74 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D05575 💬 Pramipexole [3]  2 ,  6 , 20 💬
75 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D00784 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
76 Dopaminergic synapse 💬
 [3] DRD2, DRD3, DRD4 💬 D08489 💬 Ropinirole [4]  2 ,  6 , 74, 309 💬
77 Dopaminergic synapse 💬
 [1] DRD4 💬 D00283 💬 Clozapine [1]  6  💬
78 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel [3]  2 ,  6 , 144 💬
79 Dopaminergic synapse 💬
 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 D02696 💬 Talampanel [2]  2 ,  6  💬
80 Dopaminergic synapse 💬
 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 D00775 💬 Riluzole [9]  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
81 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D02780 💬 Acamprosate [2]  6 , 206 💬
82 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D07058 💬 Acamprosate [2]  6 , 206 💬
83 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D00777 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
84 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D07441 💬 Amantadine [4]  6 ,  8 , 13, 127 💬
85 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D00848 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
86 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D03742 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
87 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D03744 💬 Dextromethorphan [11]  2 ,  6 ,  8 , 13, 21, 46, 78, 85, 96, 97, 156 💬
88 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D07283 💬 Esketamine [3]  2 ,  4 , 70 💬
89 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D00711 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
90 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D08098 💬 Ketamine [8]  2 ,  4 ,  6 , 13, 70, 113, 156, 215 💬
91 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D09917 💬 Latrepirdine [1]  8  💬
92 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D04905 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
93 Dopaminergic synapse 💬
 [2] GRIN2A, GRIN2B 💬 D08174 💬 Memantine [7]  2 ,  6 ,  8 , 13, 49, 127, 205 💬
94 Dopaminergic synapse 💬
 [3] KCNJ3, KCNJ5, SCN1A 💬 D00636 💬 Amiodarone [2] 28, 127 💬
95 Dopaminergic synapse 💬
 [3] KCNJ3, KCNJ5, SCN1A 💬 D02910 💬 Amiodarone [2] 28, 127 💬
96 Dopaminergic synapse 💬
 [1] MAOA 💬 D02561 💬 Moclobemide [1]  6  💬
97 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 D02579 💬 Iproniazid [1]  6  💬
98 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 D00505 💬 Phenelzine [1]  6  💬
99 Dopaminergic synapse 💬
 [2] MAOA, MAOB 💬 D08349 💬 Phenelzine [1]  6  💬
100 Dopaminergic synapse 💬
 [3] MAOA, MAOB, SLC6A3 💬 D05458 💬 Phentermine [1] 97 💬
101 Dopaminergic synapse 💬
 [3] MAOA, MAOB, SLC6A3 💬 D05459 💬 Phentermine [1] 97 💬
102 Dopaminergic synapse 💬
 [1] MAOB 💬 D02562 💬 Rasagiline [7]  2 ,  5 ,  6 , 13, 17, 58, 66 💬
103 Dopaminergic synapse 💬
 [1] MAOB 💬 D08469 💬 Rasagiline [7]  2 ,  5 ,  6 , 13, 17, 58, 66 💬
104 Dopaminergic synapse 💬
 [1] MAOB 💬 D10829 💬 Rasagiline [7]  2 ,  5 ,  6 , 13, 17, 58, 66 💬
105 Dopaminergic synapse 💬
 [1] MAOB 💬 D10158 💬 Safinamide [2]  6 , 17 💬
106 Dopaminergic synapse 💬
 [1] MAOB 💬 D00785 💬 Selegiline [1]  6  💬
107 Dopaminergic synapse 💬
 [1] MAOB 💬 D03731 💬 Selegiline [1]  6  💬
108 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
109 Dopaminergic synapse 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
110 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
111 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D05480 💬 Pimecrolimus [1] 160 💬
112 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
113 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
114 Dopaminergic synapse 💬
 [3] PPP3CA, PPP3CB, PPP3CC 💬 D09033 💬 Voclosporin [1] 222 💬
115 Dopaminergic synapse 💬
 [1] SCN1A 💬 D01450 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
116 Dopaminergic synapse 💬
 [1] SCN1A 💬 D07552 💬 Bupivacaine [8] 46, 51, 53, 70, 96, 168, 226, 298 💬
117 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00252 💬 Carbamazepine [2] 13, 231 💬
118 Dopaminergic synapse 💬
 [1] SCN1A 💬 D03492 💬 Cibenzoline [1] 58 💬
119 Dopaminergic synapse 💬
 [1] SCN1A 💬 D11155 💬 Eleclazine [1] 58 💬
120 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00638 💬 Flecainide [1]  6  💬
121 Dopaminergic synapse 💬
 [1] SCN1A 💬 D07962 💬 Flecainide [1]  6  💬
122 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00354 💬 Lamotrigine [5] 13, 34, 38, 114, 144 💬
123 Dopaminergic synapse 💬
 [1] SCN1A 💬 D01287 💬 Levobupivacaine [1] 46 💬
124 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08116 💬 Levobupivacaine [1] 46 💬
125 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00358 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
126 Dopaminergic synapse 💬
 [1] SCN1A 💬 D02086 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
127 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08127 💬 Lidocaine [13]  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
128 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00639 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬
129 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08215 💬 Mexiletine [5]  1 ,  2 , 10, 113, 114 💬
130 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00533 💬 Oxcarbazepine [1] 13 💬
131 Dopaminergic synapse 💬
 [1] SCN1A 💬 D01768 💬 Oxybuprocaine [1]  6  💬
132 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08319 💬 Oxybuprocaine [1]  6  💬
133 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00512 💬 Phenytoin [1] 13 💬
134 Dopaminergic synapse 💬
 [1] SCN1A 💬 D02103 💬 Phenytoin [1] 13 💬
135 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00642 💬 Quinidine [3]  2 ,  8 , 13 💬
136 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00643 💬 Quinidine [3]  2 ,  8 , 13 💬
137 Dopaminergic synapse 💬
 [1] SCN1A 💬 D02272 💬 Quinidine [3]  2 ,  8 , 13 💬
138 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08458 💬 Quinidine [3]  2 ,  8 , 13 💬
139 Dopaminergic synapse 💬
 [1] SCN1A 💬 D04048 💬 Ropivacaine [3] 36, 46, 70 💬
140 Dopaminergic synapse 💬
 [1] SCN1A 💬 D08490 💬 Ropivacaine [3] 36, 46, 70 💬
141 Dopaminergic synapse 💬
 [1] SCN1A 💬 D05775 💬 Rufinamide [1] 144 💬
142 Dopaminergic synapse 💬
 [1] SCN1A 💬 D00538 💬 Zonisamide [1]  6  💬
143 Dopaminergic synapse 💬
 [1] SLC18A2 💬 D10701 💬 Deutetrabenazine [1]  8  💬
144 Dopaminergic synapse 💬
 [1] SLC18A2 💬 D08575 💬 Tetrabenazine [1]  8  💬
145 Dopaminergic synapse 💬
 [1] SLC18A2 💬 D10675 💬 Valbenazine [1]  8  💬
146 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D03215 💬 Armodafinil [3]  6 , 13, 84 💬
147 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D00817 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
148 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D07591 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
149 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D07938 💬 Bupropion [5]  8 , 18, 21, 96, 171 💬
150 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D08130 💬 Lisdexamfetamine [1] 13 💬
151 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D01296 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬
152 Dopaminergic synapse 💬
 [1] SLC6A3 💬 D04999 💬 Methylphenidate [7]  6 , 13, 34, 84, 113, 179, 206 💬