Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank Disease ID
1 Lipid and atherosclerosis 💬
 [1] BCL2 💬 D10679 💬 Venetoclax [1] 28 💬
2 Lipid and atherosclerosis 💬
 [1] CASP9 💬 D11195 💬 Rimiducid [6] 19, 60, 65, 284, 285, 326 💬
3 Lipid and atherosclerosis 💬
 [4] CCL2, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
4 Lipid and atherosclerosis 💬
 [1] CD40 💬 D11357 💬 Bleselumab [1] 222 💬
5 Lipid and atherosclerosis 💬
 [1] CD40 💬 D11610 💬 Iscalimab [2] 49, 53 💬
6 Lipid and atherosclerosis 💬
 [1] CD40 💬 D11597 💬 Ravagalimab [2] 53, 97 💬
7 Lipid and atherosclerosis 💬
 [1] CD40LG 💬 D06193 💬 Toralizumab [1] 63 💬
8 Lipid and atherosclerosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab [1] 49 💬
9 Lipid and atherosclerosis 💬
 [13] IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab [1] 49 💬
10 Lipid and atherosclerosis 💬
 [2] IL12A, IL12B 💬 D09214 💬 Ustekinumab [17] 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
11 Lipid and atherosclerosis 💬
 [1] IL1B 💬 D09315 💬 Canakinumab [10] 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
12 Lipid and atherosclerosis 💬
 [1] IL1B 💬 D09911 💬 Gevokizumab [4] 41, 50, 56, 269 💬
13 Lipid and atherosclerosis 💬
 [1] IL1B 💬 D06635 💬 Rilonacept [4] 51, 106, 107, 266 💬
14 Lipid and atherosclerosis 💬
 [1] IL6 💬 D09669 💬 Siltuximab [2] 28, 331 💬
15 Lipid and atherosclerosis 💬
 [1] IL6 💬 D10080 💬 Sirukumab [2] 41, 46 💬
16 Lipid and atherosclerosis 💬
 [2] IL6, TNF 💬 D08976 💬 Pomalidomide [6] 28, 34, 51, 85, 227, 331 💬
17 Lipid and atherosclerosis 💬
 [1] JAK2 💬 D10308 💬 Baricitinib [13] 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
18 Lipid and atherosclerosis 💬
 [1] JAK2 💬 D10653 💬 Peficitinib [1] 46 💬
19 Lipid and atherosclerosis 💬
 [1] JAK2 💬 D09959 💬 Ruxolitinib [1] 228 💬
20 Lipid and atherosclerosis 💬
 [1] JAK2 💬 D09970 💬 Tofacitinib [15] 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
21 Lipid and atherosclerosis 💬
 [1] MAP3K5 💬 D10988 💬 Selonsertib [1] 86 💬
22 Lipid and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod [2] 113, 222 💬
23 Lipid and atherosclerosis 💬
 [4] MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod [1]  8  💬
24 Lipid and atherosclerosis 💬
 [1] NFE2L2 💬 D10964 💬 Omaveloxolone [1] 18 💬
25 Lipid and atherosclerosis 💬
 [1] NFKB1 💬 D01146 💬 Iguratimod [4] 46, 51, 53, 271 💬
26 Lipid and atherosclerosis 💬
 [3] PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib [2] 53, 65 💬
27 Lipid and atherosclerosis 💬
 [1] PIK3CD 💬 D11437 💬 Parsaclisib [3] 35, 53, 61 💬
28 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D11603 💬 Leriglitazone [1] 20 💬
29 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D00945 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
30 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D08378 💬 Pioglitazone [17]  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
31 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D00596 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
32 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D08491 💬 Rosiglitazone [5] 46, 75, 97, 222, 265 💬
33 Lipid and atherosclerosis 💬
 [1] PPARG 💬 D11256 💬 Seladelpar [2] 93, 94 💬
34 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine [44] 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
35 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus [1] 160 💬
36 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
37 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus [34]  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
38 Lipid and atherosclerosis 💬
 [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin [1] 222 💬
39 Lipid and atherosclerosis 💬
 [1] RELA 💬 D12181 💬 Edasalonexent [1] 113 💬
40 Lipid and atherosclerosis 💬
 [1] ROCK2 💬 D11815 💬 Belumosudil [1] 51 💬
41 Lipid and atherosclerosis 💬
 [1] ROCK2 💬 D07941 💬 Fasudil [4]  2 ,  5 ,  7 , 51 💬
42 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 D02754 💬 Acitretin [1] 37 💬
43 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 D02815 💬 Alitretinoin [1] 49 💬
44 Lipid and atherosclerosis 💬
 [3] RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene [2] 13, 75 💬
45 Lipid and atherosclerosis 💬
 [1] SRC 💬 D03252 💬 Bosutinib [2]  2 , 67 💬
46 Lipid and atherosclerosis 💬
 [1] SRC 💬 D03658 💬 Dasatinib [2] 51, 85 💬
47 Lipid and atherosclerosis 💬
 [1] SRC 💬 D06414 💬 Dasatinib [2] 51, 85 💬
48 Lipid and atherosclerosis 💬
 [1] SRC 💬 D09664 💬 Saracatinib [3]  6 , 89, 272 💬
49 Lipid and atherosclerosis 💬
 [1] TNF 💬 D02597 💬 Adalimumab [18] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
50 Lipid and atherosclerosis 💬
 [1] TNF 💬 D03441 💬 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271 💬
51 Lipid and atherosclerosis 💬
 [1] TNF 💬 D00742 💬 Etanercept [17] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
52 Lipid and atherosclerosis 💬
 [1] TNF 💬 D04358 💬 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271 💬
53 Lipid and atherosclerosis 💬
 [1] TNF 💬 D02598 💬 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
54 Lipid and atherosclerosis 💬
 [1] TNF 💬 D04687 💬 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331 💬
55 Lipid and atherosclerosis 💬
 [1] TNF 💬 D09944 💬 Ozoralizumab [1] 46 💬
56 Lipid and atherosclerosis 💬
 [1] TNF 💬 D05393 💬 Pegsunercept [1] 46 💬
57 Lipid and atherosclerosis 💬
 [1] TNF 💬 D00754 💬 Thalidomide [20]  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬