Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Hematopoietic cell lineage 💬
1件: ANPEP 💬 D00087 💬 Ubenimex 1件: 86 💬
2 Hematopoietic cell lineage 💬
1件: CD19 💬 D11757 💬 Inebilizumab 4件: 11, 13, 51, 300 💬
3 Hematopoietic cell lineage 💬
1件: CD22 💬 D04036 💬 Epratuzumab 1件: 49 💬
4 Hematopoietic cell lineage 💬
1件: CD38 💬 D10777 💬 Daratumumab 5件: 16, 28, 49, 63, 222 💬
5 Hematopoietic cell lineage 💬
1件: CD38 💬 D11050 💬 Isatuximab 2件: 28, 61 💬
6 Hematopoietic cell lineage 💬
1件: CD38 💬 D11945 💬 Mezagitamab 1件: 66 💬
7 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab 3件: 60, 96, 97 💬
8 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab 1件: 46 💬
9 Hematopoietic cell lineage 💬
3件: CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab 2件: 96, 97 💬
10 Hematopoietic cell lineage 💬
2件: CD3E, MS4A1 💬 D11463 💬 Mosunetuzumab 1件: 49 💬
11 Hematopoietic cell lineage 💬
3件: CSF1, FLT3, KIT 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
12 Hematopoietic cell lineage 💬
3件: CSF1, FLT3, KIT 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
13 Hematopoietic cell lineage 💬
3件: CSF1R, FLT3, KIT 💬 D11270 💬 Pexidartinib 1件: 34 💬
14 Hematopoietic cell lineage 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
15 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 D09930 💬 Mavrilimumab 2件: 41, 46 💬
16 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 D05066 💬 Molgramostim 3件: 97, 229, 299 💬
17 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 D05712 💬 Regramostim 1件: 229 💬
18 Hematopoietic cell lineage 💬
1件: CSF2RA 💬 D05803 💬 Sargramostim 7件:  6 , 28, 60, 62, 96, 229, 285 💬
19 Hematopoietic cell lineage 💬
1件: CSF3R 💬 D03235 💬 Filgrastim 34件:  2 ,  6 , 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬
20 Hematopoietic cell lineage 💬
1件: CSF3R 💬 D03247 💬 Lenograstim 7件:  2 , 13, 16, 18, 19, 57, 65 💬
21 Hematopoietic cell lineage 💬
1件: CSF3R 💬 D06889 💬 Pegfilgrastim 1件: 60 💬
22 Hematopoietic cell lineage 💬
1件: EPOR 💬 D03231 💬 Erythropoietin 10件:  2 ,  6 , 13, 18, 22, 46, 47, 70, 95, 96 💬
23 Hematopoietic cell lineage 💬
1件: EPOR 💬 D09946 💬 Peginesatide 1件: 283 💬
24 Hematopoietic cell lineage 💬
2件: FLT3, KIT 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
25 Hematopoietic cell lineage 💬
2件: FLT3, KIT 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
26 Hematopoietic cell lineage 💬
14件: HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
27 Hematopoietic cell lineage 💬
1件: IL11RA 💬 D05266 💬 Oprelvekin 2件: 96, 288 💬
28 Hematopoietic cell lineage 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
29 Hematopoietic cell lineage 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
30 Hematopoietic cell lineage 💬
4件: IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
31 Hematopoietic cell lineage 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
32 Hematopoietic cell lineage 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
33 Hematopoietic cell lineage 💬
2件: IL1R1, IL1R2 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
34 Hematopoietic cell lineage 💬
1件: IL2RA 💬 D00748 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
35 Hematopoietic cell lineage 💬
1件: IL2RA 💬 D03058 💬 Basiliximab 6件:  2 , 50, 66, 97, 222, 228 💬
36 Hematopoietic cell lineage 💬
1件: IL2RA 💬 D03639 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
37 Hematopoietic cell lineage 💬
1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
38 Hematopoietic cell lineage 💬
1件: IL4R 💬 D10354 💬 Dupilumab 4件: 51, 98, 160, 162 💬
39 Hematopoietic cell lineage 💬
1件: IL5 💬 D04923 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
40 Hematopoietic cell lineage 💬
1件: IL5 💬 D08985 💬 Reslizumab 2件: 44, 98 💬
41 Hematopoietic cell lineage 💬
1件: IL5RA 💬 D09874 💬 Benralizumab 5件: 44, 45, 98, 162, 299 💬
42 Hematopoietic cell lineage 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
43 Hematopoietic cell lineage 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
44 Hematopoietic cell lineage 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
45 Hematopoietic cell lineage 💬
1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
46 Hematopoietic cell lineage 💬
1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
47 Hematopoietic cell lineage 💬
1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
48 Hematopoietic cell lineage 💬
1件: ITGA4 💬 D10540 💬 Abrilumab 2件: 96, 97 💬
49 Hematopoietic cell lineage 💬
1件: ITGA4 💬 D06590 💬 Firategrast 1件: 13 💬
50 Hematopoietic cell lineage 💬
1件: ITGA4 💬 D06886 💬 Natalizumab 6件: 13, 15, 25, 46, 63, 96 💬
51 Hematopoietic cell lineage 💬
1件: ITGA4 💬 D08083 💬 Vedolizumab 3件: 94, 96, 97 💬
52 Hematopoietic cell lineage 💬
1件: KIT 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
53 Hematopoietic cell lineage 💬
1件: KIT 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
54 Hematopoietic cell lineage 💬
1件: KIT 💬 D01441 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
55 Hematopoietic cell lineage 💬
1件: KIT 💬 D08066 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
56 Hematopoietic cell lineage 💬
1件: KIT 💬 D10229 💬 Masitinib 6件:  2 ,  5 ,  6 , 13, 46, 96 💬
57 Hematopoietic cell lineage 💬
1件: KIT 💬 D08953 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬
58 Hematopoietic cell lineage 💬
1件: MME 💬 D10225 💬 Sacubitril 1件: 58 💬
59 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D09321 💬 Obinutuzumab 2件: 49, 222 💬
60 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D05218 💬 Ocrelizumab 3件: 13, 46, 49 💬
61 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D09314 💬 Ofatumumab 3件: 13, 35, 46 💬
62 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D02994 💬 Rituximab 49件:  6 , 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
63 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D11243 💬 Ublituximab 1件: 13 💬
64 Hematopoietic cell lineage 💬
1件: MS4A1 💬 D09031 💬 Veltuzumab 1件: 46 💬
65 Hematopoietic cell lineage 💬
1件: TFRC 💬 D11812 💬 Pabinafusp alfa 1件: 19 💬
66 Hematopoietic cell lineage 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
67 Hematopoietic cell lineage 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
68 Hematopoietic cell lineage 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
69 Hematopoietic cell lineage 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
70 Hematopoietic cell lineage 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
71 Hematopoietic cell lineage 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
72 Hematopoietic cell lineage 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
73 Hematopoietic cell lineage 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
74 Hematopoietic cell lineage 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬