Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Purine metabolism 💬
1件: ADA 💬 D11017 💬 Elapegademase 1件: 65 💬
2 Purine metabolism 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite 1件: 58 💬
3 Purine metabolism 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
4 Purine metabolism 💬
1件: GUCY2C 💬 D09355 💬 Linaclotide 2件:  6 , 97 💬
5 Purine metabolism 💬
1件: HPRT1 💬 D00161 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
6 Purine metabolism 💬
1件: HPRT1 💬 D04931 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
7 Purine metabolism 💬
1件: HPRT1 💬 D06109 💬 Tioguanine 2件: 13, 37 💬
8 Purine metabolism 💬
1件: HPRT1 💬 D08603 💬 Tioguanine 2件: 13, 37 💬
9 Purine metabolism 💬
2件: IMPDH1, IMPDH2 💬 D01392 💬 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224 💬
10 Purine metabolism 💬
2件: IMPDH1, IMPDH2 💬 D00752 💬 Mycophenolate mofetil 34件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
11 Purine metabolism 💬
2件: IMPDH1, IMPDH2 💬 D05094 💬 Mycophenolate mofetil 34件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
12 Purine metabolism 💬
2件: IMPDH1, IMPDH2 💬 D05095 💬 Mycophenolate mofetil 34件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬
13 Purine metabolism 💬
2件: IMPDH1, IMPDH2 💬 D05096 💬 Mycophenolic acid 36件:  2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬
14 Purine metabolism 💬
1件: NPR1 💬 D05147 💬 Nesiritide 2件: 46, 58 💬
15 Purine metabolism 💬
2件: NPR1, NPR2 💬 D04051 💬 Erythrityl tetranitrate 1件: 46 💬
16 Purine metabolism 💬
1件: NPR2 💬 D11190 💬 Vosoritide 1件: 276 💬
17 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00227 💬 Aminophylline 1件: 63 💬
18 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D05429 💬 Aminophylline 1件: 63 💬
19 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07546 💬 Bucladesine 1件: 246 💬
20 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00718 💬 Flavoxate 1件: 226 💬
21 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D07961 💬 Flavoxate 1件: 226 💬
22 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
23 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
24 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D02017 💬 Theophylline 2件: 236, 299 💬
25 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
26 Purine metabolism 💬
16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B 💬 D06104 💬 Theophylline 2件: 236, 299 💬
27 Purine metabolism 💬
9件: PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
28 Purine metabolism 💬
9件: PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
29 Purine metabolism 💬
2件: PDE3A, PDE3B 💬 D01896 💬 Cilostazol 3件: 51, 70, 124 💬
30 Purine metabolism 💬
2件: PDE3A, PDE3B 💬 D04720 💬 Levosimendan 1件:  2  💬
31 Purine metabolism 💬
2件: PDE3A, PDE3B 💬 D00417 💬 Milrinone 1件: 294 💬
32 Purine metabolism 💬
2件: PDE3A, PDE3B 💬 D02085 💬 Milrinone 1件: 294 💬
33 Purine metabolism 💬
6件: PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 D01385 💬 Ibudilast 2件:  2 , 13 💬
34 Purine metabolism 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D08860 💬 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271 💬
35 Purine metabolism 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D05744 💬 Roflumilast 2件: 84, 299 💬
36 Purine metabolism 💬
4件: PDE4A, PDE4B, PDE4C, PDE4D 💬 D01783 💬 Rolipram 2件:  8 , 13 💬
37 Purine metabolism 💬
2件: PDE4A, PDE5A 💬 D00302 💬 Dipyridamole 6件: 46, 49, 51, 66, 96, 224 💬
38 Purine metabolism 💬
1件: PDE5A 💬 D02229 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
39 Purine metabolism 💬
1件: PDE5A 💬 D08514 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
40 Purine metabolism 💬
1件: PDE5A 💬 D02008 💬 Tadalafil 7件:  6 , 51, 75, 84, 86, 113, 210 💬
41 Purine metabolism 💬
1件: PDE5A 💬 D10027 💬 Udenafil 2件: 86, 210 💬
42 Purine metabolism 💬
1件: PDE5A 💬 D02731 💬 Vardenafil 3件: 13, 86, 299 💬
43 Purine metabolism 💬
1件: PDE5A 💬 D03260 💬 Vardenafil 3件: 13, 86, 299 💬
44 Purine metabolism 💬
1件: PDE5A 💬 D08668 💬 Vardenafil 3件: 13, 86, 299 💬
45 Purine metabolism 💬
1件: RRM1 💬 D01370 💬 Cladribine 3件: 11, 13, 94 💬
46 Purine metabolism 💬
1件: RRM1 💬 D03546 💬 Clofarabine 9件: 19, 20, 40, 46, 49, 60, 96, 234, 326 💬
47 Purine metabolism 💬
1件: RRM1 💬 D01907 💬 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
48 Purine metabolism 💬
1件: RRM1 💬 D07966 💬 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
49 Purine metabolism 💬
1件: RRM2 💬 D00341 💬 Hydroxyurea 8件:  3 , 13, 19, 20, 65, 85, 86, 284 💬
50 Purine metabolism 💬
1件: XDH 💬 D00224 💬 Allopurinol 6件:  6 , 46, 57, 66, 96, 97 💬
51 Purine metabolism 💬
1件: XDH 💬 D01206 💬 Febuxostat 3件:  2 ,  6 , 13 💬