Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Renin secretion 💬
1件: ACE 💬 D00620 💬 Benazepril 4件: 49, 57, 218, 224 💬
2 Renin secretion 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
3 Renin secretion 💬
1件: ACE 💬 D00251 💬 Captopril 8件:  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Renin secretion 💬
1件: ACE 💬 D01069 💬 Cilazapril 1件: 66 💬
5 Renin secretion 💬
1件: ACE 💬 D07699 💬 Cilazapril 1件: 66 💬
6 Renin secretion 💬
1件: ACE 💬 D00621 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
7 Renin secretion 💬
1件: ACE 💬 D07892 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
8 Renin secretion 💬
1件: ACE 💬 D08068 💬 Imidapril 1件: 67 💬
9 Renin secretion 💬
1件: ACE 💬 D00362 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
10 Renin secretion 💬
1件: ACE 💬 D08131 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
11 Renin secretion 💬
1件: ACE 💬 D00623 💬 Moexipril 1件: 93 💬
12 Renin secretion 💬
1件: ACE 💬 D08225 💬 Moexipril 1件: 93 💬
13 Renin secretion 💬
1件: ACE 💬 D00624 💬 Perindopril 4件: 58, 113, 167, 222 💬
14 Renin secretion 💬
1件: ACE 💬 D03753 💬 Perindopril 4件: 58, 113, 167, 222 💬
15 Renin secretion 💬
1件: ACE 💬 D00459 💬 Quinapril 1件: 19 💬
16 Renin secretion 💬
1件: ACE 💬 D03752 💬 Quinapril 1件: 19 💬
17 Renin secretion 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
18 Renin secretion 💬
1件: ADORA1 💬 D00045 💬 Adenosine 3件: 13, 58, 65 💬
19 Renin secretion 💬
1件: ADORA1 💬 D02769 💬 Adenosine phosphate 1件: 46 💬
20 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D00227 💬 Aminophylline 1件: 63 💬
21 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D05429 💬 Aminophylline 1件: 63 💬
22 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
23 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
24 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D02017 💬 Theophylline 2件: 236, 299 💬
25 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
26 Renin secretion 💬
6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D06104 💬 Theophylline 2件: 236, 299 💬
27 Renin secretion 💬
4件: ADORA1, PDE1B, PDE3A, PDE3B 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
28 Renin secretion 💬
4件: ADORA1, PDE1B, PDE3A, PDE3B 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
29 Renin secretion 💬
1件: ADRB1 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
30 Renin secretion 💬
1件: ADRB1 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
31 Renin secretion 💬
1件: ADRB1 💬 D00235 💬 Atenolol 1件: 167 💬
32 Renin secretion 💬
1件: ADRB1 💬 D00634 💬 Bisoprolol 3件: 67, 86, 113 💬
33 Renin secretion 💬
1件: ADRB1 💬 D02342 💬 Bisoprolol 3件: 67, 86, 113 💬
34 Renin secretion 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
35 Renin secretion 💬
1件: ADRB1 💬 D00632 💬 Dobutamine 3件: 57, 58, 215 💬
36 Renin secretion 💬
1件: ADRB1 💬 D03879 💬 Dobutamine 3件: 57, 58, 215 💬
37 Renin secretion 💬
1件: ADRB1 💬 D03880 💬 Dobutamine 3件: 57, 58, 215 💬
38 Renin secretion 💬
1件: ADRB1 💬 D03881 💬 Dobutamine 3件: 57, 58, 215 💬
39 Renin secretion 💬
1件: ADRB1 💬 D00644 💬 Esmolol 1件: 58 💬
40 Renin secretion 💬
1件: ADRB1 💬 D07916 💬 Esmolol 1件: 58 💬
41 Renin secretion 💬
1件: ADRB1 💬 D00601 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
42 Renin secretion 💬
1件: ADRB1 💬 D02358 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
43 Renin secretion 💬
1件: ADRB1 💬 D05011 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬
44 Renin secretion 💬
1件: ADRB1 💬 D05127 💬 Nebivolol 4件: 17, 85, 113, 167 💬
45 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D00255 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
46 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D03415 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
47 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D00432 💬 Nadolol 1件:  6  💬
48 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D00378 💬 Timolol 2件: 157, 227 💬
49 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D00603 💬 Timolol 2件: 157, 227 💬
50 Renin secretion 💬
2件: ADRB1, ADRB2 💬 D08600 💬 Timolol 2件: 157, 227 💬
51 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D02349 💬 Dipivefrin 1件:  6  💬
52 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D01277 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
53 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00124 💬 Ephedrine 1件: 11 💬
54 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00095 💬 Epinephrine 3件: 46, 70, 96 💬
55 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00996 💬 Epinephrine 3件: 46, 70, 96 💬
56 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D02149 💬 Epinephrine 3件: 46, 70, 96 💬
57 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00076 💬 Norepinephrine 1件: 22 💬
58 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D05206 💬 Norepinephrine 1件: 22 💬
59 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00483 💬 Propranolol 7件:  6 , 158, 167, 215, 227, 278, 296 💬
60 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D08443 💬 Propranolol 7件:  6 , 158, 167, 215, 227, 278, 296 💬
61 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D00485 💬 Pseudoephedrine 1件: 17 💬
62 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D05648 💬 Pseudoephedrine 1件: 17 💬
63 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D05649 💬 Pseudoephedrine 1件: 17 💬
64 Renin secretion 💬
3件: ADRB1, ADRB2, ADRB3 💬 D08449 💬 Pseudoephedrine 1件: 17 💬
65 Renin secretion 💬
1件: ADRB2 💬 D07713 💬 Clenbuterol 5件:  1 ,  2 ,  6 , 13, 256 💬
66 Renin secretion 💬
1件: ADRB2 💬 D01373 💬 Formoterol 3件: 85, 228, 299 💬
67 Renin secretion 💬
1件: ADRB2 💬 D05277 💬 Formoterol 3件: 85, 228, 299 💬
68 Renin secretion 💬
1件: ADRB2 💬 D07990 💬 Formoterol 3件: 85, 228, 299 💬
69 Renin secretion 💬
1件: ADRB2 💬 D08092 💬 Isoxsuprine 1件: 13 💬
70 Renin secretion 💬
1件: ADRB2 💬 D08124 💬 Levosalbutamol 1件: 49 💬
71 Renin secretion 💬
1件: ADRB2 💬 D02147 💬 Salbutamol 14件:  3 , 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299 💬
72 Renin secretion 💬
1件: ADRB2 💬 D00687 💬 Salmeterol 1件: 299 💬
73 Renin secretion 💬
1件: ADRB2 💬 D05792 💬 Salmeterol 1件: 299 💬
74 Renin secretion 💬
1件: ADRB2 💬 D00688 💬 Terbutaline 1件: 118 💬
75 Renin secretion 💬
1件: ADRB2 💬 D08570 💬 Terbutaline 1件: 118 💬
76 Renin secretion 💬
1件: ADRB2 💬 D02151 💬 Tulobuterol 1件:  6  💬
77 Renin secretion 💬
1件: ADRB3 💬 D09535 💬 Mirabegron 4件:  6 , 13, 53, 226 💬
78 Renin secretion 💬
1件: AGTR1 💬 D00150 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
79 Renin secretion 💬
1件: AGTR1 💬 D02014 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
80 Renin secretion 💬
1件: AGTR1 💬 D00522 💬 Candesartan 2件: 58, 67 💬
81 Renin secretion 💬
1件: AGTR1 💬 D00522 💬 Candesartan cilexetil 1件: 67 💬
82 Renin secretion 💬
1件: AGTR1 💬 D00626 💬 Candesartan cilexetil 1件: 67 💬
83 Renin secretion 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
84 Renin secretion 💬
1件: AGTR1 💬 D00357 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
85 Renin secretion 💬
1件: AGTR1 💬 D08146 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
86 Renin secretion 💬
1件: AGTR1 💬 D00627 💬 Telmisartan 2件: 66, 67 💬
87 Renin secretion 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
88 Renin secretion 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
89 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
90 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
91 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
92 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
93 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
94 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
95 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
96 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
97 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
98 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
99 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
100 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
101 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
102 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
103 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
104 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
105 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
106 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
107 Renin secretion 💬
1件: EDNRA 💬 D07077 💬 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211 💬
108 Renin secretion 💬
1件: EDNRA 💬 D01227 💬 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
109 Renin secretion 💬
1件: EDNRA 💬 D07538 💬 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
110 Renin secretion 💬
1件: EDNRA 💬 D10135 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
111 Renin secretion 💬
1件: EDNRA 💬 D07171 💬 Sitaxentan 1件: 86 💬
112 Renin secretion 💬
1件: EDNRA 💬 D07741 💬 Zibotentan 1件: 51 💬
113 Renin secretion 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite 1件: 58 💬
114 Renin secretion 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
115 Renin secretion 💬
1件: NPR1 💬 D04051 💬 Erythrityl tetranitrate 1件: 46 💬
116 Renin secretion 💬
1件: NPR1 💬 D05147 💬 Nesiritide 2件: 46, 58 💬
117 Renin secretion 💬
5件: PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D07546 💬 Bucladesine 1件: 246 💬
118 Renin secretion 💬
5件: PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D00718 💬 Flavoxate 1件: 226 💬
119 Renin secretion 💬
5件: PDE1A, PDE1B, PDE1C, PDE3A, PDE3B 💬 D07961 💬 Flavoxate 1件: 226 💬
120 Renin secretion 💬
2件: PDE3A, PDE3B 💬 D01896 💬 Cilostazol 3件: 51, 70, 124 💬
121 Renin secretion 💬
2件: PDE3A, PDE3B 💬 D01385 💬 Ibudilast 2件:  2 , 13 💬
122 Renin secretion 💬
2件: PDE3A, PDE3B 💬 D04720 💬 Levosimendan 1件:  2  💬
123 Renin secretion 💬
2件: PDE3A, PDE3B 💬 D00417 💬 Milrinone 1件: 294 💬
124 Renin secretion 💬
2件: PDE3A, PDE3B 💬 D02085 💬 Milrinone 1件: 294 💬
125 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
126 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
127 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
128 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
129 Renin secretion 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
130 Renin secretion 💬
2件: PTGER2, PTGER4 💬 D00419 💬 Misoprostol 3件: 46, 70, 271 💬
131 Renin secretion 💬
1件: REN 💬 D03208 💬 Aliskiren 3件: 66, 167, 222 💬