Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00349 Isradipine 1件: 6
2 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00437 Nifedipine 2件: 50, 81
3 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
4 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00615 Amlodipine 4件: 13, 51, 67, 298
5 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00616 Diltiazem 3件: 51, 58, 86
6 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00617 Nicardipine 2件: 70, 86
7 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00619 Verapamil 3件: 96, 140, 167
8 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01173 Cilnidipine 1件: 67
9 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01908 Nilvadipine 1件: 90
10 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02356 Verapamil 3件: 96, 140, 167
11 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02914 Amlodipine 4件: 13, 51, 67, 298
12 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D03830 Diltiazem 3件: 51, 58, 86
13 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D05442 Perhexiline 2件: 58, 272
14 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07450 Amlodipine 4件: 13, 51, 67, 298
15 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07845 Diltiazem 3件: 51, 58, 86
16 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D08270 Nicardipine 2件: 70, 86
17 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D08340 Perhexiline 2件: 58, 272
18 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D08441 Propiverine 1件: 226