Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab 3件: 60, 96, 97 💬
2 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab 1件: 46 💬
3 Th17 cell differentiation 💬
3件: CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab 2件: 96, 97 💬
4 Th17 cell differentiation 💬
1件: CD3E 💬 D11463 💬 Mosunetuzumab 1件: 49 💬
5 Th17 cell differentiation 💬
14件: HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
6 Th17 cell differentiation 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
7 Th17 cell differentiation 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
8 Th17 cell differentiation 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
9 Th17 cell differentiation 💬
1件: IL17A 💬 D10071 💬 Ixekizumab 6件: 36, 37, 107, 162, 269, 271 💬
10 Th17 cell differentiation 💬
1件: IL17A 💬 D09967 💬 Secukinumab 8件: 13, 37, 41, 46, 107, 160, 269, 271 💬
11 Th17 cell differentiation 💬
1件: IL17A 💬 D11127 💬 Tibulizumab 1件: 53 💬
12 Th17 cell differentiation 💬
2件: IL17A, IL17F 💬 D11550 💬 Bimekizumab 3件: 46, 97, 271 💬
13 Th17 cell differentiation 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
14 Th17 cell differentiation 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
15 Th17 cell differentiation 💬
1件: IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
16 Th17 cell differentiation 💬
2件: IL1B, IL6 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
17 Th17 cell differentiation 💬
1件: IL1R1 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
18 Th17 cell differentiation 💬
1件: IL22 💬 D11953 💬 Efmarodocokin alfa 2件: 96, 97 💬
19 Th17 cell differentiation 💬
1件: IL23A 💬 D10912 💬 Brazikumab 2件: 96, 97 💬
20 Th17 cell differentiation 💬
1件: IL23A 💬 D10438 💬 Guselkumab 5件: 37, 41, 51, 96, 97 💬
21 Th17 cell differentiation 💬
1件: IL23A 💬 D11123 💬 Mirikizumab 3件: 37, 96, 97 💬
22 Th17 cell differentiation 💬
1件: IL23A 💬 D11052 💬 Risankizumab 4件: 37, 96, 97, 271 💬
23 Th17 cell differentiation 💬
1件: IL23A 💬 D10400 💬 Tildrakizumab 2件: 162, 271 💬
24 Th17 cell differentiation 💬
1件: IL23A 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
25 Th17 cell differentiation 💬
1件: IL2RA 💬 D03058 💬 Basiliximab 6件:  2 , 50, 66, 97, 222, 228 💬
26 Th17 cell differentiation 💬
1件: IL2RA 💬 D03639 💬 Daclizumab 8件: 13, 56, 60, 65, 97, 107, 283, 284 💬
27 Th17 cell differentiation 💬
3件: IL2RA, IL2RB, IL2RG 💬 D00748 💬 Aldesleukin 6件:  2 , 35, 49, 65, 96, 97 💬
28 Th17 cell differentiation 💬
1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
29 Th17 cell differentiation 💬
1件: IL4R 💬 D10354 💬 Dupilumab 4件: 51, 98, 160, 162 💬
30 Th17 cell differentiation 💬
1件: IL6 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
31 Th17 cell differentiation 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
32 Th17 cell differentiation 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
33 Th17 cell differentiation 💬
1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
34 Th17 cell differentiation 💬
1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
35 Th17 cell differentiation 💬
1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
36 Th17 cell differentiation 💬
1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
37 Th17 cell differentiation 💬
1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
38 Th17 cell differentiation 💬
1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
39 Th17 cell differentiation 💬
2件: JAK1, JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
40 Th17 cell differentiation 💬
2件: JAK1, JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
41 Th17 cell differentiation 💬
3件: JAK1, JAK2, JAK3 💬 D10653 💬 Peficitinib 1件: 46 💬
42 Th17 cell differentiation 💬
4件: JAK1, JAK2, JAK3, TYK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
43 Th17 cell differentiation 💬
1件: LCK 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
44 Th17 cell differentiation 💬
1件: LCK 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
45 Th17 cell differentiation 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
46 Th17 cell differentiation 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
47 Th17 cell differentiation 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
48 Th17 cell differentiation 💬
1件: MTOR 💬 D00753 💬 Sirolimus 41件:  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
49 Th17 cell differentiation 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
50 Th17 cell differentiation 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
51 Th17 cell differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
52 Th17 cell differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
53 Th17 cell differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
54 Th17 cell differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
55 Th17 cell differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
56 Th17 cell differentiation 💬
1件: PRKCQ 💬 D09671 💬 Sotrastaurin 1件: 97 💬
57 Th17 cell differentiation 💬
1件: RARA 💬 D04162 💬 Fenretinide 1件: 299 💬
58 Th17 cell differentiation 💬
1件: RARA 💬 D00348 💬 Isotretinoin 4件: 36, 39, 159, 160 💬
59 Th17 cell differentiation 💬
1件: RARA 💬 D01418 💬 Tamibarotene 2件: 26, 96 💬
60 Th17 cell differentiation 💬
1件: RARA 💬 D00094 💬 Tretinoin 6件:  2 , 62, 63, 75, 94, 231 💬
61 Th17 cell differentiation 💬
1件: RARA 💬 D06543 💬 Vitamin A 3件: 13, 53, 90 💬
62 Th17 cell differentiation 💬
4件: RARA, RXRA, RXRB, RXRG 💬 D02754 💬 Acitretin 1件: 37 💬
63 Th17 cell differentiation 💬
4件: RARA, RXRA, RXRB, RXRG 💬 D02815 💬 Alitretinoin 1件: 49 💬
64 Th17 cell differentiation 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
65 Th17 cell differentiation 💬
3件: RXRA, RXRB, RXRG 💬 D03106 💬 Bexarotene 2件: 13, 75 💬
66 Th17 cell differentiation 💬
1件: TGFB1 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
67 Th17 cell differentiation 💬
1件: TYK2 💬 D11817 💬 Deucravacitinib 2件: 96, 97 💬