Acth    (DrugBank: ACTH)

5 diseases
告示番号疾患名(ページ内リンク)臨床試験数
13多発性硬化症/視神経脊髄炎15
66IgA腎症2
145ウエスト症候群2
193プラダー・ウィリ症候群1
222一次性ネフローゼ症候群10

13. 多発性硬化症/視神経脊髄炎 [臨床試験数:3,050,薬物数:2,147(DrugBank:348),標的遺伝子数:244,標的パスウェイ数:228
Searched query = "Multiple sclerosis/Neuromyelitis optica", "Multiple sclerosis", "Neuromyelitis optica", "MS", "NMOSD", "Devic disease", "Balo concentric sclerosis", "Baló concentric sclerosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
15 / 3,050 trials found
No.TrialIDDate_
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PhaseCountries
1NCT03126760
(ClinicalTrials.gov)
May 22, 20174/4/2017Pilot Study to Assess the Efficacy & Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting Multiple SclerosisA Multicenter, Randomized, Double Blind, Placebo Controlled Parallel Group, Pilot Study to Assess the Efficacy and Safety of H.P. Acthar® Gel in Subjects With Relapsing-remitting Multiple SclerosisRelapsing, Remitting Multiple SclerosisDrug: Repository Corticotropin Injection;Drug: PlaceboMallinckrodtNULLTerminated18 YearsN/AAll35Phase 4United States
2NCT03021317
(ClinicalTrials.gov)
February 201712/1/2017Effects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune Signature During MS RelapsesEffects of ACTHAR on Advanced MRI Surrogate Markers of Disease Activity and on Comprehensive Immune Signature During MS RelapsesMultiple SclerosisDrug: ACTHarUniversity of ChicagoNULLNot yet recruiting18 YearsN/AAll18Phase 4NULL
3NCT02446886
(ClinicalTrials.gov)
June 20167/5/2015Adrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MSAdrenocorticotropic Hormone (ACTH) Effects on Myelination in Subjects With MSMultiple SclerosisDrug: Adrenocorticotropic hormone (ACTH) gel (H.P. Acthar®)Weill Medical College of Cornell UniversityMallinckrodtCompleted18 YearsN/AAll15Phase 4United States
4NCT02315872
(ClinicalTrials.gov)
May 22, 20159/12/2014ACTH for Fatigue in Multiple Sclerosis PatientsThe Effect of ACTH (Acthar) on Measures of Chronic Fatigue in Patients With Relapsing Multiple Sclerosis.Multiple Sclerosis, Relapsing-RemittingDrug: ACTH;Drug: PlaceboProvidence Health & ServicesMallinckrodtCompleted18 Years65 YearsAll8Phase 3United States
5NCT02258217
(ClinicalTrials.gov)
June 20142/10/2014Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)Tolerability of Acthar for the Treatment of Multiple Sclerosis Relapses (TAMS)Relapsing Remitting Multiple SclerosisDrug: ActharOhioHealthNULLCompleted18 YearsN/AAll30N/AUnited States
No.TrialIDDate_
enrollment
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PhaseCountries
6NCT01950234
(ClinicalTrials.gov)
October 201330/8/2013ACTH in Progressive Forms of MSTreatment of Progressive Forms of Multiple Sclerosis With Pulsed ACTH (Acthar Gel)Secondary Progressive Multiple Sclerosis;Primary Progressive Multiple Sclerosis;Progressive Relapsing Multiple SclerosisDrug: ACTH;Drug: PlaceboUniversity of MinnesotaMallinckrodtActive, not recruiting18 YearsN/AAll100Phase 2United States
7NCT02290444
(ClinicalTrials.gov)
August 201323/10/2014Effects of Acthar on Recovery From Cognitive Relapses in MSEffects of Adrenocorticotropic Hormone (ACTHAR Gel) on Recovery From Cognitive Relapses in Multiple SclerosisMultiple SclerosisDrug: Adrenocorticotropic HormoneState University of New York at BuffaloNULLCompleted18 Years65 YearsAll64Phase 3United States
8NCT01906684
(ClinicalTrials.gov)
August 201319/7/2013Comprehensive Analysis of Relapse in Multiple SclerosisComprehensive Analysis of Relapse in Multiple SclerosisMultiple SclerosisDrug: Acthar GelTanner Foundation for Multiple SclerosisQuestcor Pharmaceuticals, Inc.;Auburn University MRI Research Center;iReportoire IncNot yet recruiting19 Years65 YearsBoth20N/AUnited States
9NCT01900093
(ClinicalTrials.gov)
July 201311/7/2013Evaluation of the Response to Acthar Gel Therapy in Patients Who Failed Intravenous Methylprednisolone (IVMP) for MS RelapsesAn Open-Label Prospective Proof-Of-Concept Trial to Evaluate the Response to Acthar Gel Therapy in Patients With Multiple Sclerosis (MS) Relapses Who Have Failed To Make an Adequate Recovery After Treatment With High-Dose Intravenous MethylprednisoloneMultiple SclerosisDrug: Acthar GelAaron MillerMallinckrodtRecruiting18 Years65 YearsAll10N/AUnited States
10NCT01838174
(ClinicalTrials.gov)
May 201318/4/2013A Trial of Neuroprotection With ACTH in Acute Optic NeuritisA Phase IV Trial of Neuroprotection With ACTH in Acute Optic NeuritisMultiple SclerosisDrug: ACTHAR Gel (ACTH);Drug: IV methylprednisolone (steroids)University of Colorado, DenverMallinckrodt;University of PennsylvaniaRecruiting18 Years55 YearsAll100Phase 4United States
No.TrialIDDate_
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11NCT01888354
(ClinicalTrials.gov)
April 201316/5/2013Pilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ)Versus ACTHar Gel Five Days SQ for the Treatment of MS ExacerbationsPilot Clinical Trial of ACTHar Gel 14 Days Subcutaneous (SQ) Versus ACTHar Gel Five Days SQ for the Treatment of MS ExacerbationsMultiple Sclerosis (MS)Drug: H.P. Acthar Gel (repository corticotropin injection)The University of Texas Health Science Center, HoustonNULLCompleted18 Years55 YearsBoth25Phase 4United States
12NCT00986960
(ClinicalTrials.gov)
December 200929/9/2009Effect of Adrenocorticotropin Injection With Weekly Interferon Beta in Patients With Relapsing Remitting Multiple Sclerosis (MS)Effect of Pulsed ACTH add-on Therapy to Weekly Avonex on Remyelination and Neuroregeneration in Patients With Relapsing Remitting Multiple Sclerosis. A 1-year Placebo-controlled, Double-blinded, Randomized Follow-up StudyMultiple SclerosisDrug: repository corticotropin injection;Drug: SalineUniversity at BuffaloNULLTerminated18 Years65 YearsAll3Phase 2United States
13NCT01049451
(ClinicalTrials.gov)
November 200913/1/2010Pulse ACTH vs. MP for MSComparison of Monthly Pulse ACTH (Acthar Gel) Therapy With Methylprednisolone (MP, Solumedrol) for Long-Term Treatment of Multiple Sclerosis (MS) as an Add on Therapy to Beta-interferons (Avonex, Betaseron or Rebif)Multiple SclerosisDrug: ACTH;Drug: MethylprednisoloneUniversity of Southern CaliforniaNULLCompleted18 Years65 YearsAll23Phase 1United States
14NCT00947895
(ClinicalTrials.gov)
October 20092/7/2009Efficacy Study of Adrenocorticotropin Hormone to Treat Multiple Sclerosis (MS) Relapses After Sub-responding to an Initial 3 Day Course of Intravenous (IV) MethylprednisoloneRelative Efficacy of Repeat Course of Intravenous methyLprednisolone and Intramuscular ACTH in the Treatment of Acute Relapse of Multiple Sclerosis After Sub Response to Initial Course of Intravenous Methylprednisolone (RECLAIM): a Single Center Pilot StudyMultiple SclerosisDrug: Methylprednisolone;Drug: ACTH;Other: IV placebo;Other: IM placeboNeurologique Foundation, Inc.MallinckrodtTerminated18 YearsN/ABoth30Phase 2/Phase 3United States
15NCT00854750
(ClinicalTrials.gov)
May 200927/2/2009Modeling and Treating the Pathophysiology of Demyelination in Multiple SclerosisModeling and Treating the Pathophysiology of Demyelination in Multiple SclerosisMultiple SclerosisDrug: ACTHARElliot FrohmanQuestcor Pharmaceuticals, Inc.Terminated18 Years65 YearsBoth1Phase 4United States

66. IgA腎症 [臨床試験数:199,薬物数:214(DrugBank:57),標的遺伝子数:32,標的パスウェイ数:128
Searched query = "IgA nephropathy", "IgA nephritis", "Berger disease", "IgA-IgG nephropathy"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 199 trials found
No.TrialIDDate_
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1NCT02282930
(ClinicalTrials.gov)
March 201531/10/2014Pilot Study of ACTH in the Treatment of Immunoglobulin A (IgA) Nephropathy at High Risk of ProgressionAn Open-Label Pilot Study of ACTH in the Treatment of IgA Nephropathy at High Risk of ProgressionProgressive IgA Nephropathy;ProteinuriaDrug: ACTH (Acthar) GelMayo ClinicMallinckrodtCompleted18 YearsN/AAll20Phase 3United States
2NCT02382523
(ClinicalTrials.gov)
February 20159/1/2015Acthar on Proteinuria in IgA Nephropathy PatientsImpact of Acthar on Proteinuria and Disease Progression in IgA Nephropathy Patients With Nephrotic Range ProteinuriaIgA Nephropathy;ProteinuriaDrug: Acthar 80 unit injectionBaylor College of MedicineNULLWithdrawn18 YearsN/AAll0Phase 4United States

145. ウエスト症候群 [臨床試験数:39,薬物数:50(DrugBank:13),標的遺伝子数:27,標的パスウェイ数:24
Searched query = "West syndrome", "Infantile spasm"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
2 / 39 trials found
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
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agemin
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1NCT02092883
(ClinicalTrials.gov)
March 201314/3/2014Evaluation of Neuroinflammation in Children With Infantile SpasmsNeuroinflammation in Children With Infantile Spasms Measured With 11C-PK11195 Positron Emission Tomography: Response to ACTHInfantile SpasmsDrug: ACTHWayne State UniversityNULLCompletedN/AN/AAll8Phase 4United States
2NCT01367964
(ClinicalTrials.gov)
July 20113/6/2011Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)Early Treatment of Infants at High Risk of Developing West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)West SyndromeDrug: adrenocorticotropin hormoneAnn & Robert H Lurie Children's Hospital of ChicagoThrasher Research FundUnknown status2 Months12 MonthsAll28N/AUnited States

193. プラダー・ウィリ症候群 [臨床試験数:95,薬物数:104(DrugBank:27),標的遺伝子数:50,標的パスウェイ数:63
Searched query = "Prader-Willi syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
1 / 95 trial found
No.TrialIDDate_
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registration
Public_titleScientific_titleConditionInterventionPrimary_
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PhaseCountries
1NCT02368379
(ClinicalTrials.gov)
March 20145/2/2015Diagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi SyndromeDiagnosis of Central Adrenal Insufficiency in Patients With Prader-Willi SyndromePrader Willi Syndrome;Adrenal InsufficiencyOther: Low dose (1 mcg) ACTH stimulation test;Other: Overnight metyrapone testNationwide Children's HospitalNULLCompleted2 YearsN/AAll23N/AUnited States

222. 一次性ネフローゼ症候群 [臨床試験数:234,薬物数:241(DrugBank:78),標的遺伝子数:59,標的パスウェイ数:185
Searched query = "Primary nephrotic syndrome", "Minimal change nephrotic syndrome", "MCNS", "Membranous nephropathy", "Focal segmental glomerulosclerosis", "FSGS", "Membranoproliferative glomerulonephritis", "MPGN"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
10 / 234 trials found
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
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agemin
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PhaseCountries
1NCT02399462
(ClinicalTrials.gov)
November 20208/1/2015Acthar for Treatment of Post-transplant FSGSActhar for Treatment of Post-transplant FSGSFSGS;Renal Transplantation;Kidney TransplantationDrug: ActharUniversity of North Carolina, Chapel HillMallinckrodtNot yet recruiting18 YearsN/AAll20Phase 4United States
2NCT02683889
(ClinicalTrials.gov)
February 1, 20195/2/2016Use of Acthar in Patients With FSGS That Will be Undergoing Renal TransplantationThe Use of Acthar (ACTH) in Patients With Focal Segmental Glomerulosclerosis (FSGS) Who Have Developed Chronic Kidney Disease Stage V (CKD) or End Stage Renal Disease (ESRD) and Are Undergoing a Renal TransplantFSGSDrug: ActharUniversity of Colorado, DenverNULLRecruiting18 Years80 YearsAll20Phase 3United States
3NCT03025828
(ClinicalTrials.gov)
March 19, 201817/1/2017Adrenocorticotropic Hormone in Membranous NephropathyChanges in Autoreactive Memory B Cells as Biomarker of Response to Adrenocorticotropic Hormone in Patients With Membranous NephropathyMembranous NephropathyDrug: ACTHarIcahn School of Medicine at Mount SinaiNULLRecruiting18 Years70 YearsAll25Phase 4United States
4NCT02633046
(ClinicalTrials.gov)
May 16, 201615/12/2015Acthar for Treatment-Resistant or Treatment-Intolerant ProteinuriaTreatment of Proteinuria Due to Treatment Resistant or Treatment Intolerant Idiopathic Focal Segmental Glomerulosclerosis: A Prospective Study of Acthar (PODOCYTE)Idiopathic Focal Segmental GlomerulosclerosisDrug: Acthar GelMallinckrodt ARD LLCNULLCompleted18 YearsN/AAll64Phase 4United States;Argentina;Australia;Chile;Mexico;Peru;Turkey;Canada;Hong Kong;New Zealand;Puerto Rico
5NCT01386554
(ClinicalTrials.gov)
August 201129/6/2011Acthar for Treatment of Proteinuria in Membranous Nephropathy PatientsA Randomized, Placebo-Controlled, Parallel-Group, Double-Blind Study of H.P. Acthar Gel (Acthar) in Treatment-Resistant Subjects With Persistent Proteinuria and Nephrotic Syndrome Due to Idiopathic Membranous Nephropathy (iMN)Proteinuria;Idiopathic Membranous NephropathyDrug: Repository Corticotropin Injection;Drug: PlaceboMallinckrodtNULLCompleted18 YearsN/AAll60Phase 4United States;Canada;Chile;Mexico;Turkey
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
6NCT01093157
(ClinicalTrials.gov)
February 201024/3/2010A Dose Escalation Study of Long-acting ACTH Gel in Membranous NephropathyA Dose-finding Pilot Study of ACTH (Adrenocorticotropic Hormone) on the Proteinuria and Serum Lipoprotein Profile in Patients With Idiopathic Membranous Nephropathy (MN)GlomerulonephritisDrug: Adrenocorticotrophic hormone ACTHUniversity Health Network, TorontoMallinckrodtCompleted18 Years72 YearsAll10Phase 1/Phase 2Canada
7NCT01155141
(ClinicalTrials.gov)
September 200929/6/2010Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTHIdiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTHKidney DiseasesDrug: H.P. Acthar GelStanford UniversityMallinckrodtCompleted16 Years65 YearsAll15Phase 4United States
8NCT00805753
(ClinicalTrials.gov)
January 20099/12/2008Dose-Finding Pilot Study of ACTH in Patients With Idiopathic Membranous NephropathyA Dose-Finding Pilot Study of ACTH on the Serum Lipoprotein Profile and Proteinuria in Patients With Idiopathic Membranous Nephropathy (MN)Idiopathic Membranous NephropathyDrug: ACTHMayo ClinicQuestcor Pharmaceuticals, Inc.Completed18 YearsN/ABoth20Phase 1United States;Canada
9NCT00694863
(ClinicalTrials.gov)
July 20089/6/2008Treatment With Synthetic ACTH in High Risk Patients With Membranous NephropathyTreatment With Synthetic Adrenocorticotropic Hormone (ACTH) in Patients With Membranous Nephropathy and High Risk for Renal Failure. A Pilot StudyIdiopathic Membranous NephropathyDrug: tetracosactide hexacetaatRadboud UniversityDutch Kidney FoundationCompleted18 Years95 YearsBoth20Phase 2Netherlands
10EUCTR2008-001647-19-NL
(EUCTR)
22/05/200804/06/2008Treatment with synthetic adrenocoticotropic hormone (ACTH) in patients with membranous nephropathy and high risk for renal failure. A pilot study. - ACTHiMeNTreatment with synthetic adrenocoticotropic hormone (ACTH) in patients with membranous nephropathy and high risk for renal failure. A pilot study. - ACTHiMeN Membranous nephropathy
MedDRA version: 9.1;Level: LLT;Classification code 10027170;Term: Membranous nephropathy
Trade Name: Synacthen Depot 1mgRadboud University Nijmegen Medical CenterNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
Netherlands