Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 SIGMAR1 2件: Amyotrophic lateral sclerosis 💬, Pathways of neurodegeneration - multiple diseases 💬 D00848 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
2 SIGMAR1 2件: Amyotrophic lateral sclerosis 💬, Pathways of neurodegeneration - multiple diseases 💬 D03742 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
3 SIGMAR1 2件: Amyotrophic lateral sclerosis 💬, Pathways of neurodegeneration - multiple diseases 💬 D03744 Dextromethorphan 11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
4 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D03068 Belimumab 12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
5 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D09704 Atacicept 4件: 13, 46, 49, 66
6 CYSLTR1 2件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00529 Montelukast 8件: 6, 13, 46, 61, 63, 85, 98, 228
7 CYSLTR1 2件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01385 Ibudilast 2件: 2, 13
8 CYSLTR1 2件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D08229 Montelukast 8件: 6, 13, 46, 61, 63, 85, 98, 228
9 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
10 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
11 HRH3 1件: Neuroactive ligand-receptor interaction 💬 D08040 Histamine 1件: 13
12 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
13 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
14 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
15 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00397 Tropicamide 3件: 6, 13, 19
16 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00465 Oxybutynin 3件: 6, 13, 53
17 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00722 Oxybutynin 3件: 6, 13, 53
18 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
19 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
20 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
21 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D01269 Solifenacin 3件: 6, 13, 53
22 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D01699 Darifenacin 2件: 6, 13
23 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D03654 Darifenacin 2件: 6, 13
24 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D08522 Solifenacin 3件: 6, 13, 53
25 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00397 Tropicamide 3件: 6, 13, 19
26 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00465 Oxybutynin 3件: 6, 13, 53
27 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00722 Oxybutynin 3件: 6, 13, 53
28 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
29 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
30 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
31 CHRNA1 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
32 CHRNA1 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
33 CHRNA1 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
34 CHRNA2 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
35 CHRNA2 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
36 CHRNA2 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
37 CHRNA3 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D03365 Nicotine 3件: 6, 13, 84
38 CHRNA3 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D05156 Nicotine 3件: 6, 13, 84
39 CHRNA3 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D05157 Nicotine 3件: 6, 13, 84
40 CHRNA4 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D03365 Nicotine 3件: 6, 13, 84
41 CHRNA4 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05156 Nicotine 3件: 6, 13, 84
42 CHRNA4 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05157 Nicotine 3件: 6, 13, 84
43 CHRNA5 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
44 CHRNA5 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
45 CHRNA5 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
46 CHRNA7 7件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D03365 Nicotine 3件: 6, 13, 84
47 CHRNA7 7件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05156 Nicotine 3件: 6, 13, 84
48 CHRNA7 7件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05157 Nicotine 3件: 6, 13, 84
49 CHRNB1 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
50 CHRNB1 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
51 CHRNB1 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
52 CHRNB2 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D03365 Nicotine 3件: 6, 13, 84
53 CHRNB2 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05156 Nicotine 3件: 6, 13, 84
54 CHRNB2 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D05157 Nicotine 3件: 6, 13, 84
55 CHRNB3 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
56 CHRNB3 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
57 CHRNB3 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
58 CHRNB4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D03365 Nicotine 3件: 6, 13, 84
59 CHRNB4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D05156 Nicotine 3件: 6, 13, 84
60 CHRNB4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Chemical carcinogenesis - receptor activation 💬 D05157 Nicotine 3件: 6, 13, 84
61 CHRND 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
62 CHRND 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
63 CHRND 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
64 CHRNE 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
65 CHRNE 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
66 CHRNE 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
67 CHRNG 1件: Neuroactive ligand-receptor interaction 💬 D03365 Nicotine 2件: 13, 84
68 CHRNG 1件: Neuroactive ligand-receptor interaction 💬 D05156 Nicotine 2件: 13, 84
69 CHRNG 1件: Neuroactive ligand-receptor interaction 💬 D05157 Nicotine 2件: 13, 84
70 CLCN2 1件: Mineral absorption 💬 D04790 Lubiprostone 3件: 13, 290, 299
71 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D00306 Dronabinol 8件: 2, 8, 13, 36, 46, 96, 271, 298
72 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D05099 Nabilone 2件: 6, 13
73 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D10915 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
74 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D00306 Dronabinol 6件: 13, 36, 46, 96, 271, 298
75 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D05099 Nabilone 1件: 13
76 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D10915 Cannabidiol 16件: 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
77 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D00045 Adenosine 3件: 13, 58, 65
78 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D00528 Caffeine 9件: 2, 6, 13, 21, 46, 78, 96, 97, 265
79 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D01453 Caffeine 9件: 2, 6, 13, 21, 46, 78, 96, 97, 265
80 ADORA2A 7件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Parkinson disease 💬, Alcoholism 💬 D00045 Adenosine 3件: 13, 58, 65
81 ADORA2A 7件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Parkinson disease 💬, Alcoholism 💬 D00528 Caffeine 9件: 2, 6, 13, 21, 46, 78, 96, 97, 265
82 ADORA2A 7件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Parkinson disease 💬, Alcoholism 💬 D01453 Caffeine 9件: 2, 6, 13, 21, 46, 78, 96, 97, 265
83 ADORA2B 5件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Alcoholism 💬 D00045 Adenosine 3件: 13, 58, 65
84 ADORA3 3件: cGMP-PKG signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00045 Adenosine 3件: 13, 58, 65
85 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03235 Filgrastim 34件: 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
86 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03247 Lenograstim 7件: 2, 13, 16, 18, 19, 57, 65
87 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D01692 Alfuzosin 1件: 13
88 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D01965 Silodosin 2件: 6, 13
89 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D07124 Alfuzosin 1件: 13
90 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00776 Tizanidine 1件: 13
91 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D02076 Brimonidine 2件: 13, 90
92 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D04375 Guanabenz 2件: 2, 13
93 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D07540 Brimonidine 2件: 13, 90
94 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D08611 Tizanidine 1件: 13
95 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00776 Tizanidine 1件: 13
96 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D02076 Brimonidine 2件: 13, 90
97 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D04375 Guanabenz 2件: 2, 13
98 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D07540 Brimonidine 2件: 13, 90
99 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D08611 Tizanidine 1件: 13
100 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00776 Tizanidine 1件: 13
101 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D02076 Brimonidine 2件: 13, 90
102 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D04375 Guanabenz 2件: 2, 13
103 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D07540 Brimonidine 2件: 13, 90
104 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D08611 Tizanidine 1件: 13
105 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D02147 Salbutamol 14件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
106 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D07713 Clenbuterol 5件: 1, 2, 6, 13, 256
107 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D08092 Isoxsuprine 1件: 13
108 ADRB3 8件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D09535 Mirabegron 4件: 6, 13, 53, 226
109 CYP17A1 6件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Ovarian steroidogenesis 💬, Prolactin signaling pathway 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00351 Ketoconazole 3件: 8, 13, 75
110 DDC 9件: Tyrosine metabolism 💬, Phenylalanine metabolism 💬, Tryptophan metabolism 💬, Metabolic pathways 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Alcoholism 💬 D00558 Carbidopa 9件: 2, 4, 6, 13, 17, 90, 140, 164, 201
111 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
112 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
113 DHODH 3件: Pyrimidine metabolism 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D10172 Teriflunomide 3件: 13, 25, 26
114 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
115 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
116 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
117 DNMT1 3件: Cysteine and methionine metabolism 💬, Metabolic pathways 💬, MicroRNAs in cancer 💬 D03665 Decitabine 3件: 13, 60, 63
118 DNMT3A 3件: Cysteine and methionine metabolism 💬, Metabolic pathways 💬, MicroRNAs in cancer 💬 D03665 Decitabine 3件: 13, 60, 63
119 DNMT3B 3件: Cysteine and methionine metabolism 💬, Metabolic pathways 💬, MicroRNAs in cancer 💬 D03665 Decitabine 3件: 13, 60, 63
120 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00458 Quetiapine 2件: 6, 13
121 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D01745 Domperidone 5件: 6, 13, 17, 51, 230
122 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D07868 Domperidone 5件: 6, 13, 17, 51, 230
123 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D08456 Quetiapine 2件: 6, 13
124 ABAT 7件: Alanine, aspartate and glutamate metabolism 💬, Valine, leucine and isoleucine degradation 💬, beta-Alanine metabolism 💬, Propanoate metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
125 S1PR1 3件: FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D10001 Fingolimod 3件: 13, 14, 156
126 S1PR1 3件: FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D10968 Ozanimod 3件: 13, 96, 97
127 S1PR1 3件: FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D11215 Ponesimod 1件: 13
128 S1PR1 3件: FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D11460 Siponimod 2件: 13, 50
129 S1PR3 2件: Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D10968 Ozanimod 3件: 13, 96, 97
130 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
131 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
132 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
133 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
134 ELANE 3件: Neutrophil extracellular trap formation 💬, Transcriptional misregulation in cancer 💬, Systemic lupus erythematosus 💬 D03788 Sivelestat 3件: 13, 85, 96
135 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
136 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
137 EPOR 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03231 Erythropoietin 10件: 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
138 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00105 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
139 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00185 Estriol 2件: 13, 227
140 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00554 Ethinylestradiol 4件: 13, 46, 49, 299
141 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01413 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
142 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01617 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
143 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01953 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
144 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01986 Estriol 2件: 13, 227
145 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬,