Target Gene/Pathway Pathway / Gene

  

Search results

No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank Disease ID
1 ADORA1 [1] Sphingolipid signaling pathway D00045 Adenosine [3] 13, 58, 65
2 ADORA1 [1] Sphingolipid signaling pathway D00227 Aminophylline [1] 63
3 ADORA1 [1] Sphingolipid signaling pathway D00371 Theophylline [2] 236, 299
4 ADORA1 [1] Sphingolipid signaling pathway D00528 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
5 ADORA1 [1] Sphingolipid signaling pathway D01453 Caffeine [8] 2, 6, 21, 46, 78, 96, 97, 265
6 ADORA1 [1] Sphingolipid signaling pathway D02769 Adenosine phosphate [1] 46
7 ADORA1 [1] Sphingolipid signaling pathway D06103 Theophylline [2] 236, 299
8 ADORA3 [1] Sphingolipid signaling pathway D00045 Adenosine [3] 13, 58, 65
9 ADORA3 [1] Sphingolipid signaling pathway D02769 Adenosine phosphate [1] 46
10 ADORA3 [1] Sphingolipid signaling pathway D10971 Piclidenoson [1] 46
11 MAPK14 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
12 MAPK14 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
13 S1PR1 [1] Sphingolipid signaling pathway D10001 Fingolimod [3] 13, 14, 156
14 S1PR1 [1] Sphingolipid signaling pathway D10905 Amiselimod [1] 97
15 S1PR1 [1] Sphingolipid signaling pathway D10930 Etrasimod [3] 96, 97, 98
16 S1PR1 [1] Sphingolipid signaling pathway D10968 Ozanimod [3] 13, 96, 97
17 S1PR1 [1] Sphingolipid signaling pathway D11215 Ponesimod [1] 13
18 S1PR1 [1] Sphingolipid signaling pathway D11283 Cenerimod [1] 49
19 S1PR1 [1] Sphingolipid signaling pathway D11460 Siponimod [2] 13, 50
20 S1PR3 [1] Sphingolipid signaling pathway D10905 Amiselimod [1] 97
21 S1PR3 [1] Sphingolipid signaling pathway D10930 Etrasimod [3] 96, 97, 98
22 S1PR3 [1] Sphingolipid signaling pathway D10968 Ozanimod [3] 13, 96, 97
23 FCER1A [1] Sphingolipid signaling pathway D05251 Omalizumab [7] 46, 53, 65, 98, 162, 226, 299
24 FYN [3] Sphingolipid signaling pathway, T cell receptor signaling pathway, Viral myocarditis D03658 Dasatinib [2] 51, 85
25 FYN [3] Sphingolipid signaling pathway, T cell receptor signaling pathway, Viral myocarditis D06414 Dasatinib [2] 51, 85
26 MAP3K5 [5] Sphingolipid signaling pathway, Tight junction, TNF signaling pathway, Thermogenesis, Spinocerebellar ataxia D10988 Selonsertib [1] 86
27 NFKB1 [11] Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D01146 Iguratimod [5] 46, 51, 53, 271, 300
28 OPRD1 [1] Sphingolipid signaling pathway D05111 Nalmefene [1] 6
29 OPRD1 [1] Sphingolipid signaling pathway D05113 Naltrexone [13] 6, 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226
30 OPRD1 [1] Sphingolipid signaling pathway D05312 Oxycodone [5] 6, 13, 70, 226, 298
31 OPRD1 [1] Sphingolipid signaling pathway D08144 Loperamide [2] 13, 97
32 OPRD1 [1] Sphingolipid signaling pathway D08246 Nalbuphine [1] 85
33 OPRD1 [1] Sphingolipid signaling pathway D08249 Naloxone [2] 6, 226
34 PIK3CA [10] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11011 Alpelisib [1] 138
35 PIK3CA [10] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
36 PIK3CB [10] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
37 PIK3CD [10] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11158 Leniolisib [2] 53, 65
38 PIK3CD [10] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Yersinia infection, Viral carcinogenesis D11437 Parsaclisib [3] 35, 53, 61
39 S1PR5 [1] Sphingolipid signaling pathway D10905 Amiselimod [1] 97
40 S1PR5 [1] Sphingolipid signaling pathway D10930 Etrasimod [3] 96, 97, 98
41 S1PR5 [1] Sphingolipid signaling pathway D10968 Ozanimod [3] 13, 96, 97
42 S1PR5 [1] Sphingolipid signaling pathway D11460 Siponimod [2] 13, 50
43 PRKCB [7] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, VEGF signaling pathway, Thyroid hormone synthesis, Thyroid hormone signaling pathway, Spinocerebellar ataxia D11935 Enzastaurin [1] 168
44 PRKCE [4] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Tight junction, Type II diabetes mellitus D09671 Sotrastaurin [1] 97
45 MAPK11 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
46 MAPK11 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
47 MAPK13 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
48 MAPK13 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
49 MAP2K1 [9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D09666 Selumetinib [1] 34
50 MAP2K1 [9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
51 MAP2K1 [9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10405 Cobimetinib [1] 280
52 MAP2K1 [9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10604 Binimetinib [1] 34
53 MAP2K1 [9] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D11675 Mirdametinib [1] 34
54 MAP2K2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D09666 Selumetinib [1] 34
55 MAP2K2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10175 Trametinib [4] 2, 34, 279, 280
56 MAP2K2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10405 Cobimetinib [1] 280
57 MAP2K2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D10604 Binimetinib [1] 34
58 MAP2K2 [8] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Yersinia infection, Thyroid cancer D11675 Mirdametinib [1] 34
59 RAF1 [6] Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, T cell receptor signaling pathway, Thyroid hormone signaling pathway, Tuberculosis D08524 Sorafenib [2] 34, 86
60 BCL2 [3] Sphingolipid signaling pathway, Toxoplasmosis, Tuberculosis D10679 Venetoclax [1] 28
61 RELA [11] Sphingolipid signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis D12181 Edasalonexent [1] 113
62 ROCK1 [5] Sphingolipid signaling pathway, Vascular smooth muscle contraction, TGF-beta signaling pathway, Tight junction, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
63 MAPK12 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D09639 Losmapimod [2] 113, 222
64 MAPK12 [11] Sphingolipid signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Thermogenesis, Yersinia infection, Toxoplasmosis, Tuberculosis D10959 Neflamapimod [1] 8
65 SMPD1 [1] Sphingolipid signaling pathway D10820 Olipudase alfa [1] 19
66 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00742 Etanercept [16] 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285
67 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D00754 Thalidomide [20] 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
68 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D01583 Pirfenidone [11] 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
69 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02597 Adalimumab [17] 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 160, 164, 222, 226, 269, 270, 271
70 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D02598 Infliximab [27] 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271
71 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D03441 Certolizumab pegol [8] 37, 46, 49, 96, 97, 107, 226, 271
72 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04358 Golimumab [8] 46, 56, 84, 96, 97, 107, 270, 271
73 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D04687 Lenalidomide [8] 16, 26, 28, 34, 49, 284, 300, 331
74 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D05393 Pegsunercept [1] 46
75 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D08976 Pomalidomide [5] 28, 51, 85, 227, 331
76 TNF [12] Viral protein interaction with cytokine and cytokine receptor, Sphingolipid signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Type II diabetes mellitus, Type I diabetes mellitus, Yersinia infection, Toxoplasmosis, Tuberculosis, Systemic lupus erythematosus D09944 Ozoralizumab [1] 46
77 S1PR4 [1] Sphingolipid signaling pathway D10905 Amiselimod [1] 97
78 S1PR4 [1] Sphingolipid signaling pathway D10930 Etrasimod [3] 96, 97, 98
79 S1PR4 [1] Sphingolipid signaling pathway D10968 Ozanimod [3] 13, 96, 97
80 S1PR2 [1] Sphingolipid signaling pathway D10905 Amiselimod [1] 97
81 S1PR2 [1] Sphingolipid signaling pathway D10930 Etrasimod [3] 96, 97, 98
82 S1PR2 [1] Sphingolipid signaling pathway D10968 Ozanimod [3] 13, 96, 97
83 ROCK2 [5] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Yersinia infection D07941 Fasudil [4] 2, 5, 7, 51
84 ROCK2 [5] Sphingolipid signaling pathway, Vascular smooth muscle contraction, Wnt signaling pathway, Tight junction, Yersinia infection D11815 Belumosudil [2] 51, 85