Lidocaine ( DrugBank: Lidocaine )


12 diseases
告示番号疾患名(ページ内リンク)臨床試験数
6パーキンソン病3
13多発性硬化症/視神経脊髄炎1
22もやもや病1
34神経線維腫症1
46悪性関節リウマチ4
51全身性強皮症1
70広範脊柱管狭窄症1
86肺動脈性肺高血圧症1
107若年性特発性関節炎1
168エーラス・ダンロス症候群2
226間質性膀胱炎(ハンナ型)11
256筋型糖原病1

6. パーキンソン病


臨床試験数 : 2,307 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT02236260
(ClinicalTrials.gov)
September 3, 201429/8/2014Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain StimulationEvaluation of the Benefit Provided by the Addition of Acupunctural Analgesia With Electrostimulation to Conventional Local Anesthesia Compared to Conventional Local Anesthesia Alone in Surgery of Deep Brain Stimulation for Movement Disorders.Parkinson's DiseaseProcedure: Electroacupuncture;Drug: Local Anesthesia (lidocaine hydrochloride)Nantes University HospitalNULLCompleted18 Years74 YearsAll20N/AFrance
2JPRN-UMIN000009099
2012/10/0112/10/2012The effect of lidocaine injection into the external oblique in Parkinson's disease patients with upper camptorcormiaThe effect of lidocaine injection into the external oblique in Parkinson's disease patients with upper camptorcormia - The effect of lidocaine injection in Parkinson's disease patients with camptorcormia Parkinson's diseaselidocaine injection into the external oblique
normal saline injection into the external oblique
Parkinson's disease and Movement Disorder CenterNULLRecruiting20years-oldNot applicableMale and Female10Not applicableJapan
3JPRN-UMIN000007617
2012/04/0130/03/2012Effect of lidocaine injection for postural deformities in Parkinson's diseaseEffect of lidocaine injection for postural deformities in Parkinson's disease - Lidocaine injection for postural deformities Parkinson's diseaseintramuscular injection of lidocaineDept. of Clinical pharmacology and Neurology, Ehime UniversityNULLRecruiting20years-old80years-oldMale and Female30Not selectedJapan

13. 多発性硬化症/視神経脊髄炎


臨床試験数 : 3,340 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
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gender
Target_
size
PhaseCountries
1NCT00414453
(ClinicalTrials.gov)
January 200719/12/2006Trial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple SclerosisTrial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple Sclerosis (TALENT-MS)Neuropathic Pain;Chronic Pain;Multiple SclerosisDrug: Lidocaine patch 5%;Drug: Extended-release oxycodone;Drug: Placebo extended-release oxycodone pills;Drug: Placebo lidocaine patchesUniversity of RochesterEndo PharmaceuticalsTerminated18 YearsN/AAll19Phase 4United States

22. もやもや病


臨床試験数 : 17 薬物数 : 22 - (DrugBank : 17) / 標的遺伝子数 : 33 - 標的パスウェイ数 : 45
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1ChiCTR2100050015
2021-08-122021-08-15Effect of stellate ganglion block on intracranial vascular and stress level in patients with Moyamoya diseaseEffect of stellate ganglion block on intracranial vascular and stress level in patients with Moyamoya disease Moyamoya diseasestellate ganglion group:1.5% lidocaine planetary ganglion block; control group:DSA only, no stellate ganglion block;the First Affiliated Hospital of Sun Yat-Sen UniversityNULLPending1265Bothstellate ganglion group:12; control group:12;China

34. 神経線維腫症


臨床試験数 : 133 薬物数 : 186 - (DrugBank : 67) / 標的遺伝子数 : 79 - 標的パスウェイ数 : 190
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT03513757
(ClinicalTrials.gov)
March 4, 20184/2/2018Dexmedetomidine and Propofol for Pediatric MRI SedationAn Observer-blinded Randomized Study of Propofol Infusion vs Bolus Dexmedetomidine and Propofol Sedation for Pediatric Magnetic Resonance ImagingHeadache;Tumor;Seizure Disorder;Neurofibromatoses;Hydrocephalus;Abdominal Neoplasm;Spine DeformityDrug: propofol;Drug: Dexmedetomidine;Drug: Glycopyrrolate;Drug: Lidocaine 1% Injectable Solution;Drug: Nitrous Oxide;Drug: SevofluraneMedical College of WisconsinNULLCompleted12 Months60 MonthsAll40Phase 4United States

46. 悪性関節リウマチ


臨床試験数 : 4,356 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1JPRN-jRCTs041200048
02/10/202002/10/2020Certolizumab Pegol treatment with Reducing and stoppIng MEthotrexate in patients with Rheumatoid Arthritis in stable low disease activity-stateCertolizumab Pegol treatment with Reducing and stoppIng MEthotrexate in patients with Rheumatoid Arthritis in stable low disease activity-state - PRIMERA study Rheumatoid arthritis1) MTX*
- Continued group:
Continued at a stable dose and interval throughout the cours of the study.
Folic acid is continued if concomitantly used.
- Withdrawn group:
Week 0 to 12
Reduced after registration.
The dose of MTX is reduced to half, regardless of the initial dose.
Folic acid is continued if concomitantly used.
Week 12 to 52
Discontinued if low disease activity was maintained.
Folic acid is discontinued if concomitantly used.
*The allowable range of adherence is -20% to +20%.

2) CZP and csDMARDs other than MTX
Continued at a stable dose and interval throughout the course of the study in both groups.

3) Glucocorticoids
Continued at a stable dose up to week 36, and allowedto taper after week 36 in both group.

4) Rescue treatment
One or more of the following rescue treatments are performed if the CDAI score was >10 and at the discretion of the investigator and/or upon patient request.
- Restoring, restarting, or increasing doses of MTX
- Increasing doses of or adding csDMARDs other than MTX.
- Increasing doses of or adding glucocorticoids
- Drainage of synovial fluid.
- Administering an intraarticular injection of corticosteroids, hyaluronic acid, or lidocaine.
Asai ShujiKojima ToshihisaRecruiting>= 20age oldNot applicableBoth114N/AJapan
2ChiCTR2000033004
2020-06-012020-05-17Clinical study of intravenous lidocaine infusion in patients with rheumatoid arthritisClinical study of intravenous lidocaine infusion in patients with rheumatoid arthritis Rheumatoid arthritisGroup 1:glucocorticoid;Group 2:intravenous lidocaine infusion and glucocorticoid;Group 3:intravenous lidocaine infusion;Group 4:NSAIDS;Department of Pain, Guizhou Provincial People's HospitaNULLPending1865BothGroup 1:30;Group 2:30;Group 3:30;Group 4:30;China
3JPRN-jRCT1041190125
09/03/202009/03/2020PRECIOUS-B studyPatient REported, Clinical, and Imaging OUtcomes of tapering methotrexate in patients with rheumatoid arthritis in Stable low disease activity with Baricitinib - PRECIOUS-B study Rheumatoid arthritis1) MTX*
Week 0 to 12
- Reduced after registration.
- The dosing frequency of MTX is decreased from weekly to biweekly without a change in dose, regardless of the initial dose.
- The dosing frequency of folic acid is decreased from weekly to biweekly without a change in dose if concomitantly used.
Week 12 to 52
- Discontinued if low disease activity was maintained.
- Folic acid is discontinued if concomitantly used.
*The allowable range of adherence is -20% to +20%.

2) BAR
- Continued at a stable dose and interval throughout the course of the study.

3) csDMARDs other than MTX
- Continued at a stable dose and interval throughout the course of the study.

4) Glucocorticoids
- Continued at a stable dose up to week 36, and allowed to taper after week 36.

5) Rescue treatments
One or more of the following rescue treatments are performed if the CDAI score was >10 and at the discretion of the investigator and/or upon patient request
- Changing the dosing frequency back to weekly administration, restarting, or increasing doses of MTX.
- Increasing doses of or adding csDMARDs other than MTX.
- Increasing doses of or adding glucocorticoids.
- Drainage of synovial fluid.
- Administering an intraarticular injection of corticosteroids, hyaluronic acid, or lidocaine.
Asai ShujiNULLRecruiting>= 20age oldNot applicableBoth51N/AJapan
4JPRN-jRCTs041180071
13/10/201607/03/2019T-ReX studyTocilizumab treatment with Reducing and stopping methotreXate in patients with rheumatoid arthritis in stable low disease activity-state - T-ReX study Rheumatoid arthritisAt week 0, the dosing frequency of MTX was decreased from weekly to biweekly without a change in dose, regardless of the initial dose. At week 12, MTX was discontinued if low disease activity was maintained. TCZ and csDMARDs other than MTX were continued at a stable dose and interval throughout the course of the study. Glucocorticoids were continued at a stable dose up to week 36, and allowed to taper after week 36. The use of oral analgesics (non-steroidal anti-inflammatory drugs, acetaminophen, pregabalin, and tramadol) was not prohibited during the study period. One or more of the following rescue treatments were performed if the CDAI score was >10 and at the discretion of the investigator and/or upon patient request: changing the dosing frequency back to weekly administration, restarting, or increasing doses of MTX; increasing doses of or adding csDMARDs other than MTX or glucocorticoids; and administering an intraarticular injection of corticosteroids, hyaluronic acid, or lidocaine.Kojima ToshihisaNULLComplete>= 20age oldNot applicableBoth51N/AJapan

51. 全身性強皮症


臨床試験数 : 525 薬物数 : 565 - (DrugBank : 148) / 標的遺伝子数 : 114 - 標的パスウェイ数 : 217
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT00740285
(ClinicalTrials.gov)
April 200419/8/2008Effectiveness and Safety of Lidocaine for SclerodermaEffectiveness and Safety of Lidocaine for Scleroderma. Randomized Double-Blind Clinical TrialSclerodermaDrug: Lidocaine 2% without vessel constrictor;Other: Placebo - physiological solution 0,9%Federal University of São PauloNULLCompleted18 Years60 YearsBoth26Phase 2/Phase 3Brazil

70. 広範脊柱管狭窄症


臨床試験数 : 95 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04992572
(ClinicalTrials.gov)
December 1, 202121/7/2021Study Comparing Local/ MAC Anesthesia in Lumbar DecompressionRandomized Study Comparing Local/ MAC Anesthesia to General for 1-3 Level Lumbar DecompressionsLumbar Spinal StenosisDrug: Propofol Injection;Drug: Lidocaine Hydrochloride, InjectableStanford UniversityNULLRecruiting40 Years95 YearsAll100Early Phase 1United States

86. 肺動脈性肺高血圧症


臨床試験数 : 1,205 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT01433328
(ClinicalTrials.gov)
January 20129/9/2011Lidocaine Subcutaneous Infusion for Control of Treprostinil Related Site PainLidocaine Subcutaneous Infusion for Control of Treprostinil Related Site PainPulmonary Arterial HypertensionDrug: Lidocaine;Drug: PlaceboJewish General HospitalNULLTerminated18 Years85 YearsAll4Phase 4Canada

107. 若年性特発性関節炎


臨床試験数 : 447 薬物数 : 297 - (DrugBank : 57) / 標的遺伝子数 : 52 - 標的パスウェイ数 : 146
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04775225
(ClinicalTrials.gov)
January 6, 202117/2/2021Hip Denervation in Juvenile Idiopathic Arthritis With Hip ArthritisHip Denervation in Juvenile Idiopathic ArthritisJuvenile Idiopathic Arthritis;Hip ArthritisDrug: Lidocaine;Drug: Placebo;Drug: SteroidSohag UniversityNULLCompleted2 Years18 YearsAll120Phase 3Egypt

168. エーラス・ダンロス症候群


臨床試験数 : 13 薬物数 : 21 - (DrugBank : 11) / 標的遺伝子数 : 11 - 標的パスウェイ数 : 103
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT05603741
(ClinicalTrials.gov)
November 10, 202224/10/2022Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersLocal Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersEhlers-Danlos Syndrome;Anesthesia, LocalDrug: 0.9% Sodium Chloride Injection;Drug: Lidocaine Injection 2%University of CalgaryVanderbilt University Medical CenterActive, not recruiting18 YearsN/AAll155Phase 4Canada
2NCT04036305
(ClinicalTrials.gov)
July 26, 201925/7/2019Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersLocal Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy VolunteersEhlers-Danlos Syndrome;Anesthesia, LocalDrug: 0.9% Sodium Chloride Injection;Drug: Lidocaine Injection 2%;Drug: Bupivacaine Injection 0.5%Vanderbilt University Medical CenterUniversity of CalgaryEnrolling by invitation18 YearsN/AAll230United States

226. 間質性膀胱炎(ハンナ型)


臨床試験数 : 145 薬物数 : 156 - (DrugBank : 51) / 標的遺伝子数 : 64 - 標的パスウェイ数 : 146
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT05737121
(ClinicalTrials.gov)
March 7, 202310/2/2023Safety and Efficacy Study of VNX001 Compared to Its Individual Components (Lidocaine and Heparin) or Placebo in Subjects With IC/BPSA Phase 2, Randomized, Double-Blind, Placebo-Controlled Multi-Center Single Dose Study to Evaluate the Safety and Effectiveness of VNX001 Compared to Placebo, the Individual Components of Lidocaine, and Heparin in Subjects With Interstitial Cystitis/Bladder Pain SyndromeInterstitial Cystitis;Bladder Pain SyndromeDrug: VNX001;Drug: Placebo;Drug: Lidocaine;Drug: HeparinVaneltix Pharma, Inc.Prevail Infoworks, IncNot yet recruiting18 YearsN/AAll120Phase 2United States
2NCT04401176
(ClinicalTrials.gov)
September 15, 202019/5/2020Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain SyndromeA Randomized Trial of Bladder Instillations Versus Onabotulinumtoxin A for Treatment of Interstitial Cystitis/Bladder Pain SyndromeInterstitial Cystitis;Bladder Pain SyndromeDrug: Heparin & Alkalinized Lidocaine Bladder Instillation;Drug: Onabotulinum Toxin AWalter Reed National Military Medical CenterNULLActive, not recruiting18 YearsN/AFemale58Phase 2United States
3NCT03844412
(ClinicalTrials.gov)
November 4, 201915/2/2019Vestibulodynia: Understanding Pathophysiology and Determining Appropriate TreatmentsVestibulodynia: Understanding Pathophysiology and Determining Appropriate TreatmentsVestibulodynia;Temporomandibular Disorder;Fibromyalgia Syndrome;Irritable Bowel Syndrome;Migraines;Tension Headache;Endometriosis;Interstitial Cystitis;Back Pain;Chronic Fatigue SyndromeDrug: 5% lidocaine/5 mg/ml 0.02% estradiol compound cream;Drug: Nortriptyline;Drug: Placebo cream;Drug: Placebo pillDuke UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)Recruiting18 Years50 YearsFemale400Phase 2United States
4JPRN-UMIN000027918
2016/07/0125/06/2017Heparin-lidocaine intravesical injection therapy for refractory interstitial cystitisHeparin-lidocaine intravesical injection therapy for refractory interstitial cystitis - Heparin-lidocaine intravesical injection therapy for interstitial cystitis interstitial cystitisheparin-lidocaine intravesical therapyDepartment of Urology and Renal transplantation, Nagasaki University HospitalNULLRecruiting20years-old80years-oldMale and Female30Not selectedJapan
5JPRN-UMIN000026714
2016/02/2627/03/2017RCT study of bladder instillation therapy in patients with refractory interstitial cystitis.RCT study of bladder instillation therapy in patients with refractory interstitial cystitis. - RCT study of bladder instillation therapy for refractory interstitial cystitis. Interstitial cystitisTreated with vesical instillation with heparin and alkalized lidocaine. As introduction therapy, patients will recieve instillation every 1 to 2 weeks for six times. Then maintenance therapy follows with 6 times of monthly instillation.
Treated with vesical instillation with heparin alone. As introduction therapy, patients will recieve instillation every 1 to 2 weeks for six times. Then maintenance therapy follows with 6 times of monthly instillation.
Department of Urology, Mitsui Memorial HospitalNULLPending20years-oldNot applicableMale and Female20Phase 2,3Japan
6NCT02591199
(ClinicalTrials.gov)
September 201528/10/2015Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain SyndromeA Phase 2a, Randomized, Double-Blind, Placebo-Controlled Multi-Center Single Dose Study to Evaluate the Safety and Effectiveness of URG101 Compared With the Individual Components Lidocaine and Heparin in Subjects With Interstitial Cystitis/Bladder Pain SyndromeInterstitial Cystitis;Bladder Pain SyndromeDrug: URG101;Drug: Placebo;Drug: Lidocaine;Drug: HeparinUrigenNULLTerminated18 YearsN/AAll92Phase 2United States
7NCT02517996
(ClinicalTrials.gov)
February 201523/2/2015Use of Preemptive Pudendal Nerve Block Prior to Hydrodistention for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS)Use of Preemptive Pudendal Nerve Block Prior to Hydrodistension for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS): a Prospective, Double-blinded, Randomized Control TrialInterstitial Cystitis;Painful Bladder SyndromeDrug: Lidocaine;Drug: PlaceboJohns Hopkins UniversityNULLTerminated18 YearsN/AFemale18N/AUnited States
8NCT01048177
(ClinicalTrials.gov)
December 201211/1/2010A Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized VulvodyniaA Trial of Intravesical Therapy for Interstitial Cystitis in Patients With Generalized VulvodyniaVulvodyniaDrug: Bladder instillation with heparin/ lidocaineScripps HealthNULLWithdrawn18 Years80 YearsFemale0Phase 2United States
9NCT01475253
(ClinicalTrials.gov)
November 20113/11/2011Double-Blind Placebo Controlled Study of Safety,Tolerability, and Efficacy of LiRIS® in Women With Interstitial CystitisA Phase 2a Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Safety, Tolerability and Efficacy of LiRIS® in Women With Interstitial Cystitis Followed by an Open Label ExtensionInterstitial CystitisDrug: Lidocaine Releasing Intravesical System - LiRIS®;Other: LiRIS Placebo;Procedure: Sham Cystoscopy ProcedureAllerganTARIS Biomedical, Inc.Terminated18 YearsN/AFemale104Phase 2United States;Canada
10NCT00823030
(ClinicalTrials.gov)
January 200914/1/2009Effect of Intravesical Lidocaine on Urodynamic and Symptomatic Parameters of Interstitial CystitisEffect of Intravesical Lidocaine on Urodynamic and Symptomatic Parameters of Interstitial CystitisInterstitial CystitisProcedure: Urodynamic study;Drug: Lidocaine;Other: Normal SalineNorth Shore Long Island Jewish Health SystemNULLWithdrawn18 Years80 YearsBoth0N/AUnited States
11NCT00256542
(ClinicalTrials.gov)
January 200617/11/2005Study of U101 for Bladder Pain and/or UrgencyA Phase II Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Intravesical Alkalinized Lidocaine-Heparin for the Symptoms of Pelvic Pain and/or Urgency of Bladder OriginPelvic Pain;Interstitial Cystitis;Bladder DiseasesDrug: Alkalinized Lidocaine-HeparinUrigenNULLCompleted18 YearsN/ABoth90Phase 2United States

256. 筋型糖原病


臨床試験数 : 180 薬物数 : 133 - (DrugBank : 29) / 標的遺伝子数 : 25 - 標的パスウェイ数 : 105
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT02240407
(ClinicalTrials.gov)
October 17, 201711/9/2014Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe DiseaseEvaluation of Re-administration of Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase (rAAV9-DES-hGAA) in Patients With Late-Onset Pompe Disease (LOPD)Pompe DiseaseGenetic: Recombinant Adeno-Associated Virus Acid Alpha-Glucosidase;Drug: Rapamycin;Other: saline;Drug: Rituxan;Drug: Diphenhydramine;Drug: Acetaminophen;Drug: Lidocaine;Drug: LMX 4 Topical CreamUniversity of FloridaNULLActive, not recruiting18 Years50 YearsAll2Phase 1United States