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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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45 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 2  Bladder cancer 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 3  Chagas disease (American trypanosomiasis) 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 4  Chemical carcinogenesis 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 5  Cytokine-cytokine receptor interaction 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 6  Drug metabolism - cytochrome P450 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 7  EGFR tyrosine kinase inhibitor resistance 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 8  Fatty acid degradation 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 9  Fluid shear stress and atherosclerosis 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 10  Focal adhesion 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 11  Glycolysis / Gluconeogenesis 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 12  Herpes simplex virus 1 infection 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 13  HIF-1 signaling pathway 
 3 genes, 2 drugs (DrugBank) and 10 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 14  Human cytomegalovirus infection 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 15  Human papillomavirus infection 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 16  Inflammatory bowel disease (IBD) 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 17  Influenza A 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 18  JAK-STAT signaling pathway 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 19  Kaposi sarcoma-associated herpesvirus infection 
 2 genes, 2 drugs (DrugBank) and 10 diseases shown 
 1件: IFNGR1   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 20  Leishmaniasis 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 21  MAPK signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 22  Metabolic pathways 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 23  Metabolism of xenobiotics by cytochrome P450 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 24  MicroRNAs in cancer 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 25  Natural killer cell mediated cytotoxicity 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 26  Necroptosis 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 27  Osteoclast differentiation 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 28  Pancreatic cancer 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 29  Pathways in cancer 
 3 genes, 2 drugs (DrugBank) and 10 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 30  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 31  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 32  Proteoglycans in cancer 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 33  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 34  Ras signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 35  Relaxin signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 36  Renal cell carcinoma 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 37  Retinol metabolism 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 38  Rheumatoid arthritis 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 
 39  Salmonella infection 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 40  Th1 and Th2 cell differentiation 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 41  Th17 cell differentiation 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 42  Toxoplasmosis 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 43  Tuberculosis 
 2 genes, 1 drug (DrugBank) and 7 diseases shown 
 2件: IFNGR1, IFNGR2   D00747   Interferon gamma-1b   7件: 65, 85, 90, 228, 299, 301, 326 
 44  Tyrosine metabolism 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADH1A, ADH1B, ADH1C   D00707   Fomepizole   1件: 301 
 45  VEGF signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: VEGFA   D05697   Ranibizumab   4件: 34, 166, 227, 301 

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