Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 ADH1A 9件: Glycolysis / Gluconeogenesis 💬, Fatty acid degradation 💬, Tyrosine metabolism 💬, Pyruvate metabolism 💬, Retinol metabolism 💬, Metabolism of xenobiotics by cytochrome P450 💬, Drug metabolism - cytochrome P450 💬, Metabolic pathways 💬, Alcoholic liver disease 💬 D00707 Fomepizole 1件: 301
2 ADH1B 9件: Glycolysis / Gluconeogenesis 💬, Fatty acid degradation 💬, Tyrosine metabolism 💬, Pyruvate metabolism 💬, Retinol metabolism 💬, Metabolism of xenobiotics by cytochrome P450 💬, Drug metabolism - cytochrome P450 💬, Metabolic pathways 💬, Alcoholic liver disease 💬 D00707 Fomepizole 1件: 301
3 ADH1C 9件: Glycolysis / Gluconeogenesis 💬, Fatty acid degradation 💬, Tyrosine metabolism 💬, Pyruvate metabolism 💬, Retinol metabolism 💬, Metabolism of xenobiotics by cytochrome P450 💬, Drug metabolism - cytochrome P450 💬, Metabolic pathways 💬, Alcoholic liver disease 💬 D00707 Fomepizole 1件: 301
4 IFNGR1 18件: Cytokine-cytokine receptor interaction 💬, HIF-1 signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Tuberculosis 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬 D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
5 IFNGR2 17件: Cytokine-cytokine receptor interaction 💬, HIF-1 signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Tuberculosis 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬 D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
6 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
7 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
8 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
9 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
10 VEGFA 24件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Bladder cancer 💬, Rheumatoid arthritis 💬, Fluid shear stress and atherosclerosis 💬 D05697 Ranibizumab 4件: 34, 166, 227, 301
11 PDE5A 3件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬 D02229 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
12 PDE5A 3件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬 D08514 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301