Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Chagas disease 💬
1件: ACE 💬 D00620 💬 Benazepril 4件: 49, 57, 218, 224 💬
2 Chagas disease 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
3 Chagas disease 💬
1件: ACE 💬 D00251 💬 Captopril 8件:  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Chagas disease 💬
1件: ACE 💬 D01069 💬 Cilazapril 1件: 66 💬
5 Chagas disease 💬
1件: ACE 💬 D07699 💬 Cilazapril 1件: 66 💬
6 Chagas disease 💬
1件: ACE 💬 D00621 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
7 Chagas disease 💬
1件: ACE 💬 D07892 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
8 Chagas disease 💬
1件: ACE 💬 D08068 💬 Imidapril 1件: 67 💬
9 Chagas disease 💬
1件: ACE 💬 D00362 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
10 Chagas disease 💬
1件: ACE 💬 D08131 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
11 Chagas disease 💬
1件: ACE 💬 D00623 💬 Moexipril 1件: 93 💬
12 Chagas disease 💬
1件: ACE 💬 D08225 💬 Moexipril 1件: 93 💬
13 Chagas disease 💬
1件: ACE 💬 D00624 💬 Perindopril 4件: 58, 113, 167, 222 💬
14 Chagas disease 💬
1件: ACE 💬 D03753 💬 Perindopril 4件: 58, 113, 167, 222 💬
15 Chagas disease 💬
1件: ACE 💬 D00459 💬 Quinapril 1件: 19 💬
16 Chagas disease 💬
1件: ACE 💬 D03752 💬 Quinapril 1件: 19 💬
17 Chagas disease 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
18 Chagas disease 💬
1件: C3 💬 D11613 💬 Pegcetacoplan 3件:  2 , 62, 222 💬
19 Chagas disease 💬
5件: CCL2, IL10, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
20 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab 3件: 60, 96, 97 💬
21 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab 1件: 46 💬
22 Chagas disease 💬
3件: CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab 2件: 96, 97 💬
23 Chagas disease 💬
1件: CD3E 💬 D11463 💬 Mosunetuzumab 1件: 49 💬
24 Chagas disease 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
25 Chagas disease 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
26 Chagas disease 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
27 Chagas disease 💬
2件: IL12A, IL12B 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
28 Chagas disease 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
29 Chagas disease 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
30 Chagas disease 💬
1件: IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
31 Chagas disease 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
32 Chagas disease 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
33 Chagas disease 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
34 Chagas disease 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
35 Chagas disease 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
36 Chagas disease 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
37 Chagas disease 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
38 Chagas disease 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
39 Chagas disease 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
40 Chagas disease 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
41 Chagas disease 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
42 Chagas disease 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
43 Chagas disease 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
44 Chagas disease 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
45 Chagas disease 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
46 Chagas disease 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
47 Chagas disease 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
48 Chagas disease 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
49 Chagas disease 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬