Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Cholinergic synapse 💬
1件: ACHE 💬 D00670 💬 Donepezil 9件:  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
2 Cholinergic synapse 💬
1件: ACHE 💬 D07869 💬 Donepezil 9件:  5 ,  6 , 13, 46, 78, 124, 127, 156, 206 💬
3 Cholinergic synapse 💬
1件: ACHE 💬 D02173 💬 Galantamine 2件:  6 , 127 💬
4 Cholinergic synapse 💬
1件: ACHE 💬 D04292 💬 Galantamine 2件:  6 , 127 💬
5 Cholinergic synapse 💬
1件: ACHE 💬 D09917 💬 Latrepirdine 1件:  8  💬
6 Cholinergic synapse 💬
1件: ACHE 💬 D08261 💬 Neostigmine 1件: 11 💬
7 Cholinergic synapse 💬
1件: ACHE 💬 D00487 💬 Pyridostigmine 4件:  3 ,  6 , 11, 256 💬
8 Cholinergic synapse 💬
1件: ACHE 💬 D02558 💬 Rivastigmine 3件:  5 ,  6 , 13 💬
9 Cholinergic synapse 💬
1件: ACHE 💬 D03822 💬 Rivastigmine 3件:  5 ,  6 , 13 💬
10 Cholinergic synapse 💬
1件: ACHE 💬 D02068 💬 Tacrine 3件: 46, 271, 299 💬
11 Cholinergic synapse 💬
1件: ACHE 💬 D08555 💬 Tacrine 3件: 46, 271, 299 💬
12 Cholinergic synapse 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
13 Cholinergic synapse 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
14 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
15 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
16 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
17 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
18 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
19 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
20 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
21 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
22 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
23 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
24 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
25 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
26 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
27 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
28 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
29 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
30 Cholinergic synapse 💬
9件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D08441 💬 Propiverine 1件: 226 💬
31 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00113 💬 Atropine 2件:  2 , 299 💬
32 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D01077 💬 Atropine 2件:  2 , 299 💬
33 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D02069 💬 Atropine 2件:  2 , 299 💬
34 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D03011 💬 Atropine 2件:  2 , 299 💬
35 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D03814 💬 Atropine 2件:  2 , 299 💬
36 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D01000 💬 Bethanechol 1件: 98 💬
37 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D11383 💬 Blarcamesine 1件: 156 💬
38 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00270 💬 Chlorpromazine 1件: 254 💬
39 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00789 💬 Chlorpromazine 1件: 254 💬
40 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D03274 💬 Chlorpromazine 1件: 254 💬
41 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D04034 💬 Chlorpromazine 1件: 254 💬
42 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D02212 💬 Ipratropium 2件:  6 , 86 💬
43 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00465 💬 Oxybutynin 3件:  6 , 13, 53 💬
44 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00722 💬 Oxybutynin 3件:  6 , 13, 53 💬
45 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00481 💬 Propantheline 1件: 26 💬
46 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00138 💬 Scopolamine 1件:  2  💬
47 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00787 💬 Trihexyphenidyl 2件:  5 ,  6  💬
48 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D08638 💬 Trihexyphenidyl 2件:  5 ,  6  💬
49 Cholinergic synapse 💬
5件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 D00397 💬 Tropicamide 3件:  6 , 13, 19 💬
50 Cholinergic synapse 💬
11件: CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬 D00765 💬 Rocuronium 1件: 296 💬
51 Cholinergic synapse 💬
2件: CHRM2, CHRM3 💬 D07226 💬 Fesoterodine 1件:  6  💬
52 Cholinergic synapse 💬
2件: CHRM2, CHRM3 💬 D00525 💬 Pilocarpine 3件:  6 , 53, 299 💬
53 Cholinergic synapse 💬
2件: CHRM2, CHRM3 💬 D02200 💬 Pilocarpine 3件:  6 , 53, 299 💬
54 Cholinergic synapse 💬
2件: CHRM2, CHRM3 💬 D05478 💬 Pilocarpine 3件:  6 , 53, 299 💬
55 Cholinergic synapse 💬
1件: CHRM3 💬 D00661 💬 Cevimeline 1件: 53 💬
56 Cholinergic synapse 💬
1件: CHRM3 💬 D07667 💬 Cevimeline 1件: 53 💬
57 Cholinergic synapse 💬
1件: CHRM3 💬 D01699 💬 Darifenacin 2件:  6 , 13 💬
58 Cholinergic synapse 💬
1件: CHRM3 💬 D03654 💬 Darifenacin 2件:  6 , 13 💬
59 Cholinergic synapse 💬
1件: CHRM3 💬 D01269 💬 Solifenacin 3件:  6 , 13, 53 💬
60 Cholinergic synapse 💬
1件: CHRM3 💬 D08522 💬 Solifenacin 3件:  6 , 13, 53 💬
61 Cholinergic synapse 💬
1件: CHRM3 💬 D00646 💬 Tolterodine 2件: 17, 53 💬
62 Cholinergic synapse 💬
1件: CHRM3 💬 D01148 💬 Tolterodine 2件: 17, 53 💬
63 Cholinergic synapse 💬
6件: CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬 D03365 💬 Nicotine 3件:  6 , 13, 84 💬
64 Cholinergic synapse 💬
6件: CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬 D05156 💬 Nicotine 3件:  6 , 13, 84 💬
65 Cholinergic synapse 💬
6件: CHRNA3, CHRNA4, CHRNA6, CHRNA7, CHRNB2, CHRNB4 💬 D05157 💬 Nicotine 3件:  6 , 13, 84 💬
66 Cholinergic synapse 💬
2件: CHRNA4, CHRNB2 💬 D08669 💬 Varenicline 2件:  6 , 18 💬
67 Cholinergic synapse 💬
1件: FYN 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
68 Cholinergic synapse 💬
1件: FYN 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
69 Cholinergic synapse 💬
1件: JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
70 Cholinergic synapse 💬
1件: JAK2 💬 D10653 💬 Peficitinib 1件: 46 💬
71 Cholinergic synapse 💬
1件: JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
72 Cholinergic synapse 💬
1件: JAK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
73 Cholinergic synapse 💬
3件: KCNJ12, KCNJ3, KCNQ1 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
74 Cholinergic synapse 💬
3件: KCNJ12, KCNJ3, KCNQ1 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
75 Cholinergic synapse 💬
5件: KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 D09569 💬 Ezogabine 2件:  2 , 144 💬
76 Cholinergic synapse 💬
1件: MAP2K1 💬 D10604 💬 Binimetinib 1件: 34 💬
77 Cholinergic synapse 💬
1件: MAP2K1 💬 D10405 💬 Cobimetinib 1件: 280 💬
78 Cholinergic synapse 💬
1件: MAP2K1 💬 D09666 💬 Selumetinib 1件: 34 💬
79 Cholinergic synapse 💬
1件: MAP2K1 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
80 Cholinergic synapse 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
81 Cholinergic synapse 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬