Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 MAP2K1 89件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Oocyte meiosis 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Yersinia infection 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D09666 Selumetinib 1件: 34
2 MAP2K1 89件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Oocyte meiosis 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Yersinia infection 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10175 Trametinib 4件: 2, 34, 279, 280
3 MAP2K1 89件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Oocyte meiosis 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Yersinia infection 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10405 Cobimetinib 1件: 280
4 MAP2K1 89件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Oocyte meiosis 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Yersinia infection 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10604 Binimetinib 1件: 34