Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Natural killer cell mediated cytotoxicity 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
2 Natural killer cell mediated cytotoxicity 💬
2件: BRAF, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
3 Natural killer cell mediated cytotoxicity 💬
2件: BRAF, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
4 Natural killer cell mediated cytotoxicity 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
5 Natural killer cell mediated cytotoxicity 💬
2件: FYN, LCK 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
6 Natural killer cell mediated cytotoxicity 💬
2件: FYN, LCK 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
7 Natural killer cell mediated cytotoxicity 💬
5件: HLA-A, HLA-B, HLA-C, HLA-E, HLA-G 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
8 Natural killer cell mediated cytotoxicity 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab 1件: 49 💬
9 Natural killer cell mediated cytotoxicity 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab 1件: 49 💬
10 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab 2件: 46, 49 💬
11 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa 6件: 13, 25, 26, 28, 56, 96 💬
12 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a 1件: 56 💬
13 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b 2件: 25, 34 💬
14 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a 4件: 13, 26, 96, 97 💬
15 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b 1件: 13 💬
16 Natural killer cell mediated cytotoxicity 💬
2件: IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a 1件: 13 💬
17 Natural killer cell mediated cytotoxicity 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
18 Natural killer cell mediated cytotoxicity 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
19 Natural killer cell mediated cytotoxicity 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
20 Natural killer cell mediated cytotoxicity 💬
1件: ITGAL 💬 D03959 💬 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 💬
21 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
22 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
23 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
24 Natural killer cell mediated cytotoxicity 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
25 Natural killer cell mediated cytotoxicity 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
26 Natural killer cell mediated cytotoxicity 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
27 Natural killer cell mediated cytotoxicity 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
28 Natural killer cell mediated cytotoxicity 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
29 Natural killer cell mediated cytotoxicity 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
30 Natural killer cell mediated cytotoxicity 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
31 Natural killer cell mediated cytotoxicity 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
32 Natural killer cell mediated cytotoxicity 💬
1件: SYK 💬 D09347 💬 Fostamatinib 4件: 46, 49, 61, 66 💬
33 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
34 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
35 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
36 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
37 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
38 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
39 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
40 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
41 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
42 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
43 Natural killer cell mediated cytotoxicity 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬