Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Retrograde endocannabinoid signaling 💬
5件: CACNA1B, CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
2 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
3 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
4 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
5 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
6 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
7 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
8 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
9 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
10 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
11 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
12 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
13 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
14 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
15 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
16 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
17 Retrograde endocannabinoid signaling 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
18 Retrograde endocannabinoid signaling 💬
24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
19 Retrograde endocannabinoid signaling 💬
1件: CNR1 💬 D10915 💬 Cannabidiol 19件:  2 ,  6 ,  8 , 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
20 Retrograde endocannabinoid signaling 💬
1件: CNR1 💬 D00306 💬 Dronabinol 8件:  2 ,  8 , 13, 36, 46, 96, 271, 298 💬
21 Retrograde endocannabinoid signaling 💬
1件: CNR1 💬 D05099 💬 Nabilone 2件:  6 , 13 💬
22 Retrograde endocannabinoid signaling 💬
1件: CNR1 💬 D05731 💬 Rimonabant 1件: 193 💬
23 Retrograde endocannabinoid signaling 💬
1件: GABRA1 💬 D00548 💬 Etomidate 1件:  6  💬
24 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00225 💬 Alprazolam 2件:  8 , 75 💬
25 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D11149 💬 Brexanolone 1件: 205 💬
26 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00267 💬 Chlordiazepoxide 1件: 46 💬
27 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00693 💬 Chlordiazepoxide 1件: 46 💬
28 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
29 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00280 💬 Clonazepam 1件:  6  💬
30 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D07784 💬 Delorazepam 3件:  6 , 46, 97 💬
31 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00293 💬 Diazepam 3件: 46, 155, 298 💬
32 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D02624 💬 Eszopiclone 3件:  6 , 13, 46 💬
33 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01514 💬 Etizolam 1件: 46 💬
34 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00697 💬 Flumazenil 5件:  6 , 13, 17, 18, 206 💬
35 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04282 💬 Gaboxadol 2件: 201, 206 💬
36 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D04300 💬 Ganaxolone 4件: 145, 152, 158, 206 💬
37 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00365 💬 Lorazepam 2件: 36, 231 💬
38 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00550 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
39 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00696 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
40 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D05028 💬 Midazolam 12件:  2 ,  3 ,  6 , 13, 21, 46, 70, 96, 97, 231, 272, 298 💬
41 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00549 💬 Propofol 10件:  6 , 21, 22, 34, 46, 70, 75, 84, 98, 296 💬
42 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00706 💬 Zolpidem 3件:  5 ,  6 , 46 💬
43 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D08690 💬 Zolpidem 3件:  5 ,  6 , 46 💬
44 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01372 💬 Zopiclone 1件:  6  💬
45 Retrograde endocannabinoid signaling 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件:  2 ,  6 , 144 💬
46 Retrograde endocannabinoid signaling 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D00775 💬 Riluzole 9件:  2 ,  3 ,  5 ,  8 , 13, 17, 18, 203, 206 💬
47 Retrograde endocannabinoid signaling 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D02696 💬 Talampanel 2件:  2 ,  6  💬
48 Retrograde endocannabinoid signaling 💬
2件: KCNJ3, KCNJ5 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
49 Retrograde endocannabinoid signaling 💬
2件: KCNJ3, KCNJ5 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
50 Retrograde endocannabinoid signaling 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
51 Retrograde endocannabinoid signaling 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
52 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01545 💬 Aceclofenac 1件: 46 💬
53 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00217 💬 Acetaminophen 18件:  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 💬
54 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00109 💬 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
55 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00567 💬 Celecoxib 10件:  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
56 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00903 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
57 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00904 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
58 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D07816 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
59 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00130 💬 Diflunisal 1件: 28 💬
60 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00315 💬 Etodolac 1件: 46 💬
61 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D03710 💬 Etoricoxib 2件: 46, 271 💬
62 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00330 💬 Flurbiprofen 3件: 13, 21, 46 💬
63 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01475 💬 Flurbiprofen 3件: 13, 21, 46 💬
64 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D02290 💬 Flurbiprofen 3件: 13, 21, 46 💬
65 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00126 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
66 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01122 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
67 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D04490 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
68 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D06606 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
69 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00141 💬 Indomethacin 3件: 225, 271, 298 💬
70 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01565 💬 Indomethacin 3件: 225, 271, 298 💬
71 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D02110 💬 Indomethacin 3件: 225, 271, 298 💬
72 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00132 💬 Ketoprofen 1件: 46 💬
73 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00813 💬 Ketorolac 2件: 70, 226 💬
74 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D08104 💬 Ketorolac 2件: 70, 226 💬
75 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D08149 💬 Loxoprofen 2件: 46, 271 💬
76 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D03714 💬 Lumiracoxib 1件: 46 💬
77 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
78 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00118 💬 Naproxen 4件: 13, 46, 107, 271 💬
79 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01049 💬 Nimesulide 1件: 46 💬
80 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D03716 💬 Parecoxib 2件: 46, 271 💬
81 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00568 💬 Rofecoxib 1件: 46 💬
82 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00428 💬 Salsalate 1件:  5  💬
83 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D00120 💬 Sulindac 1件: 206 💬
84 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D01183 💬 Tolfenamic acid 1件:  5  💬
85 Retrograde endocannabinoid signaling 💬
1件: PTGS2 💬 D02709 💬 Valdecoxib 1件: 46 💬