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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
1ATALUREN[1] Ataluren[1] Ataluren 💬--[6] 19, 113, 140, 246, 299, 329 💬
2Cannabidiol[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[18] 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
3Cannabidiol (CBD)[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[7] 6, 13, 140, 144, 145, 156, 158 💬
4Cannabidiol Oral Solution[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[4] 140, 144, 145, 193 💬
5CARBIDOPA[1] Carbidopa[1] Carbidopa 💬[1] DDC 💬[9] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬[7] 6, 13, 17, 90, 140, 164, 201 💬
6CBD----[13] 2, 6, 8, 13, 36, 46, 51, 140, 144, 145, 156, 158, 206 💬
7CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 140, 144 💬
8Clemizole[1] Clemizole---[2] 140, 144 💬
9CLEMIZOLE HYDROCHLORIDE[1] Clemizole---[1] 140 💬
10Clobazam[1] Clobazam[1] Clobazam 💬[16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 140, 144 💬
11DIACOMIT[1] Stiripentol[1] Stiripentol 💬--[1] 140 💬
12DIACOMIT (Stiripentol)[1] Stiripentol[1] Stiripentol 💬--[1] 140 💬
13Epidiolex[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 140, 144 💬
14Epidiolex 100 mg/mL Oral Solution[1] Cannabidiol[1] Cannabidiol 💬[2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[2] 140, 144 💬
15EPX-100----[1] 140 💬
16EPX-100 (Clemizole HCl)[1] Clemizole---[1] 140 💬
17EPX-100 (Clemizole Hydrochloride)[1] Clemizole---[1] 140 💬
18ETX101----[1] 140 💬
19Fenfluramina[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[2] 140, 144 💬
20Fenfluramina Cloridrato[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[2] 140, 144 💬
21FENFLURAMINE[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[4] 140, 144, 145, 149 💬
22FENFLURAMINE HYDROCHLORIDE[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[2] 140, 144 💬
23FENFLURAMINE HYDROCHLORIDE (colorless)[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[2] 140, 144 💬
24FENFLURAMINE HYDROCHLORIDE (red)[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[1] 140 💬
25Frisium----[1] 140 💬
26FRISIUM*30CPS 10MG----[1] 140 💬
27GWP42003-P----[5] 140, 144, 145, 156, 158 💬
28GWP42003-P 10 mg/kg/day Dose----[1] 140 💬
29GWP42003-P 20 mg/kg/day Dose----[2] 140, 144 💬
30GWP42003-P 5 mg/kg/day Dose----[1] 140 💬
31LEVODOPA[1] Levodopa[1] Levodopa 💬[5] DRD1,
DRD2,
DRD3,
DRD4,
DRD5 💬		[11] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Morphine addiction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬[6] 6, 17, 90, 140, 164, 201 💬
32Lorcaserin[1] Lorcaserin---[1] 140 💬
33LP352----[2] 140, 144 💬
34ME2080 (stiripentol)[1] Stiripentol[1] Stiripentol 💬--[1] 140 💬
35MIC----[2] 140, 144 💬
36None[1] Interleukin-1 alpha, human recombinant---[20] 6, 46, 51, 65, 66, 78, 84, 85, 96, 97, 140, 160, 161, 171, 222, 231, 246, 271, 299, 337 💬
37None at this time[1] Interleukin-1 alpha, human recombinant---[2] 96, 140 💬
38Other antiepileptics----[1] 140 💬
39PEG----[15] 6, 13, 41, 46, 60, 65, 78, 96, 97, 140, 144, 240, 246, 299, 337 💬
40Placebo----[28] 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬
41SOTICLESTAT[1] Soticlestat[1] Soticlestat 💬[1] CYP46A1 💬[1] Primary bile acid biosynthesis 💬[2] 140, 144 💬
42Stiripentol[1] Stiripentol[1] Stiripentol 💬--[1] 140 💬
43Stiripentolo----[1] 140 💬
44STK-001[1] Zorevunersen---[1] 140 💬
45STK-001 - Multiple Ascending Doses[1] Zorevunersen---[1] 140 💬
46STK-001 - Single Ascending Doses[1] Zorevunersen---[1] 140 💬
47TAK-935----[2] 140, 144 💬
48TOPAMAX[1] Topiramate[1] Topiramate 💬[36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[1] 140 💬
49TOPIRAMATE[1] Topiramate[1] Topiramate 💬[36] CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		[53] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[6] 6, 97, 140, 144, 156, 193 💬
50Turmeric[1] Turmeric---[4] 140, 144, 158, 299 💬
51Verapamil[1] Verapamil[1] Verapamil 💬[4] CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S 💬		[37] Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬[4] 58, 96, 140, 167 💬
52ZX008----[2] 140, 144 💬
53ZX008 (Fenfluramine Hydrochloride)[1] Fenfluramine[1] Fenfluramine 💬[5] HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		[10] Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬[2] 140, 144 💬
54ZX008 - 0.2 mg/kg/day----[1] 140 💬
55ZX008 - 0.8 mg/kg/day----[1] 140 💬
56ZX008 0.2 to 0.8 mg/kg/day----[2] 140, 144 💬