Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00150 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
2 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D02014 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00522 💬 Candesartan 2件: 58, 67 💬
4 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00522 💬 Candesartan cilexetil 1件: 67 💬
5 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00626 💬 Candesartan cilexetil 1件: 67 💬
6 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
7 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00357 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
8 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D08146 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00627 💬 Telmisartan 2件: 66, 67 💬
11 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
12 AGE-RAGE signaling pathway in diabetic complications 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
13 AGE-RAGE signaling pathway in diabetic complications 💬
5件: CCL2, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
14 AGE-RAGE signaling pathway in diabetic complications 💬
1件: CDK4 💬 D10688 💬 Abemaciclib 1件: 34 💬
15 AGE-RAGE signaling pathway in diabetic complications 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
16 AGE-RAGE signaling pathway in diabetic complications 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
17 AGE-RAGE signaling pathway in diabetic complications 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
18 AGE-RAGE signaling pathway in diabetic complications 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
19 AGE-RAGE signaling pathway in diabetic complications 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
20 AGE-RAGE signaling pathway in diabetic complications 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
21 AGE-RAGE signaling pathway in diabetic complications 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
22 AGE-RAGE signaling pathway in diabetic complications 💬
1件: JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
23 AGE-RAGE signaling pathway in diabetic complications 💬
1件: JAK2 💬 D10653 💬 Peficitinib 1件: 46 💬
24 AGE-RAGE signaling pathway in diabetic complications 💬
1件: JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
25 AGE-RAGE signaling pathway in diabetic complications 💬
1件: JAK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
26 AGE-RAGE signaling pathway in diabetic complications 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
27 AGE-RAGE signaling pathway in diabetic complications 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
28 AGE-RAGE signaling pathway in diabetic complications 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
29 AGE-RAGE signaling pathway in diabetic complications 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
30 AGE-RAGE signaling pathway in diabetic complications 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
31 AGE-RAGE signaling pathway in diabetic complications 💬
2件: PRKCD, PRKCE 💬 D09671 💬 Sotrastaurin 1件: 97 💬
32 AGE-RAGE signaling pathway in diabetic complications 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
33 AGE-RAGE signaling pathway in diabetic complications 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
34 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
35 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
36 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
37 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
38 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
39 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
40 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
41 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
42 AGE-RAGE signaling pathway in diabetic complications 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
43 AGE-RAGE signaling pathway in diabetic complications 💬
1件: VEGFA 💬 D06409 💬 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331 💬
44 AGE-RAGE signaling pathway in diabetic complications 💬
1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
45 AGE-RAGE signaling pathway in diabetic complications 💬
2件: VEGFA, VEGFB 💬 D09574 💬 Aflibercept 2件: 90, 166 💬