Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 B cell receptor signaling pathway 💬
1件: BTK 💬 D10893 💬 Acalabrutinib 2件: 46, 61 💬
2 B cell receptor signaling pathway 💬
1件: BTK 💬 D11478 💬 Branebrutinib 3件: 46, 49, 53 💬
3 B cell receptor signaling pathway 💬
1件: BTK 💬 D11457 💬 Fenebrutinib 1件: 13 💬
4 B cell receptor signaling pathway 💬
1件: BTK 💬 D10223 💬 Ibrutinib 3件: 28, 60, 61 💬
5 B cell receptor signaling pathway 💬
1件: BTK 💬 D12160 💬 Orelabrutinib 3件: 13, 61, 63 💬
6 B cell receptor signaling pathway 💬
1件: BTK 💬 D11422 💬 Zanubrutinib 2件: 300, 331 💬
7 B cell receptor signaling pathway 💬
1件: CD19 💬 D11757 💬 Inebilizumab 4件: 11, 13, 51, 300 💬
8 B cell receptor signaling pathway 💬
1件: CD22 💬 D04036 💬 Epratuzumab 1件: 49 💬
9 B cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
10 B cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
11 B cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
12 B cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
13 B cell receptor signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
14 B cell receptor signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
15 B cell receptor signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
16 B cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
17 B cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
18 B cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
19 B cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
20 B cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
21 B cell receptor signaling pathway 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
22 B cell receptor signaling pathway 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
23 B cell receptor signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
24 B cell receptor signaling pathway 💬
1件: SYK 💬 D09347 💬 Fostamatinib 4件: 46, 49, 61, 66 💬