Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00620 💬 Benazepril 4件: 49, 57, 218, 224 💬
2 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D07499 💬 Benazepril 4件: 49, 57, 218, 224 💬
3 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00251 💬 Captopril 8件:  6 , 17, 46, 86, 96, 97, 107, 271 💬
4 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D01069 💬 Cilazapril 1件: 66 💬
5 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D07699 💬 Cilazapril 1件: 66 💬
6 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00621 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
7 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D07892 💬 Enalapril 6件: 19, 46, 66, 113, 210, 222 💬
8 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D08068 💬 Imidapril 1件: 67 💬
9 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00362 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
10 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D08131 💬 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222 💬
11 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00623 💬 Moexipril 1件: 93 💬
12 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D08225 💬 Moexipril 1件: 93 💬
13 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00624 💬 Perindopril 4件: 58, 113, 167, 222 💬
14 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D03753 💬 Perindopril 4件: 58, 113, 167, 222 💬
15 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00459 💬 Quinapril 1件: 19 💬
16 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D03752 💬 Quinapril 1件: 19 💬
17 Coronavirus disease - COVID-19 💬
1件: ACE 💬 D00421 💬 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257 💬
18 Coronavirus disease - COVID-19 💬
1件: ADAM17 💬 D08859 💬 Apratastat 1件: 46 💬
19 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00150 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
20 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D02014 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
21 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00522 💬 Candesartan 2件: 58, 67 💬
22 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00522 💬 Candesartan cilexetil 1件: 67 💬
23 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00626 💬 Candesartan cilexetil 1件: 67 💬
24 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
25 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00357 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
26 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D08146 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
27 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
28 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00627 💬 Telmisartan 2件: 66, 67 💬
29 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
30 Coronavirus disease - COVID-19 💬
2件: C1R, C1S 💬 D10845 💬 Conestat alfa 1件: 61 💬
31 Coronavirus disease - COVID-19 💬
1件: C1S 💬 D11530 💬 Sutimlimab 1件: 61 💬
32 Coronavirus disease - COVID-19 💬
1件: C3 💬 D11613 💬 Pegcetacoplan 3件:  2 , 62, 222 💬
33 Coronavirus disease - COVID-19 💬
1件: C5 💬 D11696 💬 Crovalimab 2件: 62, 109 💬
34 Coronavirus disease - COVID-19 💬
1件: C5 💬 D03940 💬 Eculizumab 7件: 11, 13, 14, 61, 62, 109, 222 💬
35 Coronavirus disease - COVID-19 💬
1件: C5 💬 D11473 💬 Nomacopan 3件: 62, 109, 162 💬
36 Coronavirus disease - COVID-19 💬
1件: C5 💬 D11477 💬 Pozelimab 2件: 11, 62 💬
37 Coronavirus disease - COVID-19 💬
1件: C5 💬 D11054 💬 Ravulizumab 7件:  2 , 11, 13, 50, 62, 66, 109 💬
38 Coronavirus disease - COVID-19 💬
1件: C5 💬 D11838 💬 Vilobelimab 3件: 43, 44, 269 💬
39 Coronavirus disease - COVID-19 💬
1件: C5AR1 💬 D11093 💬 Avacopan 3件: 43, 44, 222 💬
40 Coronavirus disease - COVID-19 💬
4件: CCL2, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
41 Coronavirus disease - COVID-19 💬
1件: CFB 💬 D12251 💬 Iptacopan 5件: 61, 62, 66, 109, 222 💬
42 Coronavirus disease - COVID-19 💬
1件: CFD 💬 D11641 💬 Danicopan 2件: 62, 222 💬
43 Coronavirus disease - COVID-19 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
44 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
45 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
46 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
47 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
48 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
49 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
50 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
51 Coronavirus disease - COVID-19 💬
1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
52 Coronavirus disease - COVID-19 💬
1件: F2 💬 D09707 💬 Dabigatran 4件: 51, 85, 91, 124 💬
53 Coronavirus disease - COVID-19 💬
1件: F2 💬 D07144 💬 Dabigatran etexilate 1件: 51 💬
54 Coronavirus disease - COVID-19 💬
1件: F2 💬 D06410 💬 Thrombomodulin Alfa 1件: 85 💬
55 Coronavirus disease - COVID-19 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab 1件: 49 💬
56 Coronavirus disease - COVID-19 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab 1件: 49 💬
57 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab 2件: 46, 49 💬
58 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa 6件: 13, 25, 26, 28, 56, 96 💬
59 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a 1件: 56 💬
60 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b 2件: 25, 34 💬
61 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a 4件: 13, 26, 96, 97 💬
62 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b 1件: 13 💬
63 Coronavirus disease - COVID-19 💬
2件: IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a 1件: 13 💬
64 Coronavirus disease - COVID-19 💬
2件: IL12A, IL12B 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
65 Coronavirus disease - COVID-19 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
66 Coronavirus disease - COVID-19 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
67 Coronavirus disease - COVID-19 💬
1件: IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
68 Coronavirus disease - COVID-19 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
69 Coronavirus disease - COVID-19 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
70 Coronavirus disease - COVID-19 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
71 Coronavirus disease - COVID-19 💬
1件: IL6R 💬 D10161 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬
72 Coronavirus disease - COVID-19 💬
1件: IL6R 💬 D11079 💬 Satralizumab 2件: 11, 13 💬
73 Coronavirus disease - COVID-19 💬
1件: IL6R 💬 D02596 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬
74 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
75 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
76 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
77 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D10653 💬 Peficitinib 1件: 46 💬
78 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D09959 💬 Ruxolitinib 1件: 228 💬
79 Coronavirus disease - COVID-19 💬
1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
80 Coronavirus disease - COVID-19 💬
2件: JAK1, TYK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
81 Coronavirus disease - COVID-19 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
82 Coronavirus disease - COVID-19 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
83 Coronavirus disease - COVID-19 💬
1件: MASP2 💬 D11531 💬 Narsoplimab 4件: 64, 66, 109, 222 💬
84 Coronavirus disease - COVID-19 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
85 Coronavirus disease - COVID-19 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
86 Coronavirus disease - COVID-19 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
87 Coronavirus disease - COVID-19 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
88 Coronavirus disease - COVID-19 💬
1件: SYK 💬 D09347 💬 Fostamatinib 4件: 46, 49, 61, 66 💬
89 Coronavirus disease - COVID-19 💬
1件: TLR7 💬 D02500 💬 Imiquimod 2件: 34, 51 💬
90 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
91 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
92 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
93 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
94 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
95 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
96 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
97 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
98 Coronavirus disease - COVID-19 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
99 Coronavirus disease - COVID-19 💬
1件: TYK2 💬 D11817 💬 Deucravacitinib 2件: 96, 97 💬
100 Coronavirus disease - COVID-19 💬
1件: VWF 💬 D11160 💬 Caplacizumab 1件: 64 💬