Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Cushing syndrome 💬
1件: AGTR1 💬 D00150 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
2 Cushing syndrome 💬
1件: AGTR1 💬 D02014 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
3 Cushing syndrome 💬
1件: AGTR1 💬 D00522 💬 Candesartan 2件: 58, 67 💬
4 Cushing syndrome 💬
1件: AGTR1 💬 D00522 💬 Candesartan cilexetil 1件: 67 💬
5 Cushing syndrome 💬
1件: AGTR1 💬 D00626 💬 Candesartan cilexetil 1件: 67 💬
6 Cushing syndrome 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
7 Cushing syndrome 💬
1件: AGTR1 💬 D00357 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
8 Cushing syndrome 💬
1件: AGTR1 💬 D08146 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
9 Cushing syndrome 💬
1件: AGTR1 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
10 Cushing syndrome 💬
1件: AGTR1 💬 D00627 💬 Telmisartan 2件: 66, 67 💬
11 Cushing syndrome 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
12 Cushing syndrome 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
13 Cushing syndrome 💬
1件: BRAF 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
14 Cushing syndrome 💬
1件: BRAF 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
15 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
16 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
17 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
18 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
19 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
20 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
21 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
22 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
23 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
24 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
25 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
26 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
27 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
28 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
29 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
30 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
31 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
32 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
33 Cushing syndrome 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D01303 💬 Flunarizine 4件: 58, 86, 149, 215 💬
34 Cushing syndrome 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D07971 💬 Flunarizine 4件: 58, 86, 149, 215 💬
35 Cushing syndrome 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00399 💬 Valproic acid 17件:  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331 💬
36 Cushing syndrome 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00538 💬 Zonisamide 1件:  6  💬
37 Cushing syndrome 💬
2件: CDK4, CDK6 💬 D10688 💬 Abemaciclib 1件: 34 💬
38 Cushing syndrome 💬
2件: CRHR1, CRHR2 💬 D03905 💬 Corticorelin 2件: 75, 205 💬
39 Cushing syndrome 💬
2件: CRHR1, CRHR2 💬 D03592 💬 Corticorelin ovine triflutate 1件: 75 💬
40 Cushing syndrome 💬
1件: CYP11B1 💬 D00410 💬 Metyrapone 2件: 75, 193 💬
41 Cushing syndrome 💬
1件: CYP11B1 💬 D05019 💬 Metyrapone 2件: 75, 193 💬
42 Cushing syndrome 💬
1件: CYP17A1 💬 D00351 💬 Ketoconazole 3件:  8 , 13, 75 💬
43 Cushing syndrome 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
44 Cushing syndrome 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
45 Cushing syndrome 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
46 Cushing syndrome 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
47 Cushing syndrome 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
48 Cushing syndrome 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
49 Cushing syndrome 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
50 Cushing syndrome 💬
1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
51 Cushing syndrome 💬
1件: KCNA4 💬 D10228 💬 Amifampridine 3件:  3 , 11, 12 💬
52 Cushing syndrome 💬
1件: KCNA4 💬 D04127 💬 Dalfampridine 5件:  3 ,  4 ,  6 , 13, 14 💬
53 Cushing syndrome 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
54 Cushing syndrome 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
55 Cushing syndrome 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
56 Cushing syndrome 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
57 Cushing syndrome 💬
1件: MC2R 💬 D00146 💬 Corticotropin 15件:  2 , 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222 💬
58 Cushing syndrome 💬
1件: MC2R 💬 D00284 💬 Tetracosactide 5件: 78, 83, 113, 145, 222 💬
59 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D00227 💬 Aminophylline 1件: 63 💬
60 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D05429 💬 Aminophylline 1件: 63 💬
61 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D07546 💬 Bucladesine 1件: 246 💬
62 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D00718 💬 Flavoxate 1件: 226 💬
63 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D07961 💬 Flavoxate 1件: 226 💬
64 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
65 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
66 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D02017 💬 Theophylline 2件: 236, 299 💬
67 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
68 Cushing syndrome 💬
3件: PDE11A, PDE8A, PDE8B 💬 D06104 💬 Theophylline 2件: 236, 299 💬