Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Estrogen signaling pathway 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
2 Estrogen signaling pathway 💬
1件: EGFR 💬 D03455 💬 Cetuximab 5件: 34, 51, 86, 89, 331 💬
3 Estrogen signaling pathway 💬
1件: EGFR 💬 D04023 💬 Erlotinib 1件: 94 💬
4 Estrogen signaling pathway 💬
1件: EGFR 💬 D07907 💬 Erlotinib 1件: 94 💬
5 Estrogen signaling pathway 💬
1件: EGFR 💬 D01977 💬 Gefitinib 1件: 75 💬
6 Estrogen signaling pathway 💬
1件: EGFR 💬 D11251 💬 Icotinib 1件: 34 💬
7 Estrogen signaling pathway 💬
1件: EGFR 💬 D04024 💬 Lapatinib 3件: 34, 74, 75 💬
8 Estrogen signaling pathway 💬
1件: EGFR 💬 D08108 💬 Lapatinib 3件: 34, 74, 75 💬
9 Estrogen signaling pathway 💬
1件: EGFR 💬 D11772 💬 Tesevatinib 1件: 67 💬
10 Estrogen signaling pathway 💬
1件: ESR1 💬 D00554 💬 Ethinylestradiol 4件: 13, 46, 49, 299 💬
11 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D00962 💬 Clomifene 1件: 74 💬
12 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D07726 💬 Clomifene 1件: 74 💬
13 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D11513 💬 Estetrol 1件: 53 💬
14 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D11514 💬 Estetrol 1件: 53 💬
15 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D00105 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
16 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01413 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
17 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01617 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
18 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01953 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
19 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D04061 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
20 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D04063 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
21 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D04064 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
22 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D04065 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
23 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01413 💬 Estradiol valerate 1件: 65 💬
24 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D00185 💬 Estriol 2件: 13, 227 💬
25 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01986 💬 Estriol 2件: 13, 227 💬
26 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D01161 💬 Fulvestrant 2件: 49, 86 💬
27 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D00575 💬 Mestranol 2件: 46, 49 💬
28 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D08409 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
29 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D02217 💬 Raloxifene 1件: 46 💬
30 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D08465 💬 Raloxifene 1件: 46 💬
31 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D00966 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
32 Estrogen signaling pathway 💬
2件: ESR1, ESR2 💬 D08559 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
33 Estrogen signaling pathway 💬
2件: ESR1, PGR 💬 D00289 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
34 Estrogen signaling pathway 💬
2件: ESR1, PGR 💬 D02367 💬 Desogestrel 1件: 230 💬
35 Estrogen signaling pathway 💬
2件: GABBR1, GABBR2 💬 D09791 💬 Arbaclofen 2件: 13, 206 💬
36 Estrogen signaling pathway 💬
2件: GABBR1, GABBR2 💬 D08861 💬 Arbaclofen Placarbil 1件: 13 💬
37 Estrogen signaling pathway 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 7件:  2 , 10, 13, 18, 65, 149, 206 💬
38 Estrogen signaling pathway 💬
2件: KCNJ3, KCNJ5 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
39 Estrogen signaling pathway 💬
2件: KCNJ3, KCNJ5 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
40 Estrogen signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
41 Estrogen signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
42 Estrogen signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
43 Estrogen signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
44 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00836 💬 Buprenorphine 3件: 46, 70, 298 💬
45 Estrogen signaling pathway 💬
1件: OPRM1 💬 D07132 💬 Buprenorphine 3件: 46, 70, 298 💬
46 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01481 💬 Dihydrocodeine 1件: 310 💬
47 Estrogen signaling pathway 💬
1件: OPRM1 💬 D07831 💬 Dihydrocodeine 1件: 310 💬
48 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00320 💬 Fentanyl 4件: 46, 70, 215, 231 💬
49 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01399 💬 Fentanyl 4件: 46, 70, 215, 231 💬
50 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00839 💬 Hydromorphone 1件: 70 💬
51 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08047 💬 Hydromorphone 1件: 70 💬
52 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00729 💬 Loperamide 2件: 13, 97 💬
53 Estrogen signaling pathway 💬
1件: OPRM1 💬 D07113 💬 Loperamide 2件: 13, 97 💬
54 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08144 💬 Loperamide 2件: 13, 97 💬
55 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01383 💬 Meperidine 1件: 298 💬
56 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08343 💬 Meperidine 1件: 298 💬
57 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00842 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
58 Estrogen signaling pathway 💬
1件: OPRM1 💬 D02271 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
59 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08233 💬 Morphine 6件: 36, 46, 70, 85, 86, 298 💬
60 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00843 💬 Nalbuphine 1件: 85 💬
61 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08246 💬 Nalbuphine 1件: 85 💬
62 Estrogen signaling pathway 💬
1件: OPRM1 💬 D05111 💬 Nalmefene 1件:  6  💬
63 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01340 💬 Naloxone 2件:  6 , 226 💬
64 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08249 💬 Naloxone 2件:  6 , 226 💬
65 Estrogen signaling pathway 💬
1件: OPRM1 💬 D02095 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
66 Estrogen signaling pathway 💬
1件: OPRM1 💬 D05113 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
67 Estrogen signaling pathway 💬
1件: OPRM1 💬 D03783 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
68 Estrogen signaling pathway 💬
1件: OPRM1 💬 D05312 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
69 Estrogen signaling pathway 💬
1件: OPRM1 💬 D05462 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
70 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08323 💬 Oxymorphone 1件: 70 💬
71 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01177 💬 Remifentanil 2件:  6 , 70 💬
72 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08473 💬 Remifentanil 2件:  6 , 70 💬
73 Estrogen signaling pathway 💬
1件: OPRM1 💬 D00845 💬 Sufentanil 2件: 70, 280 💬
74 Estrogen signaling pathway 💬
1件: OPRM1 💬 D05938 💬 Sufentanil 2件: 70, 280 💬
75 Estrogen signaling pathway 💬
1件: OPRM1 💬 D01355 💬 Tramadol 5件: 46, 70, 78, 226, 271 💬
76 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08623 💬 Tramadol 5件: 46, 70, 78, 226, 271 💬
77 Estrogen signaling pathway 💬
1件: OPRM1 💬 D08639 💬 Trimebutine 1件: 51 💬
78 Estrogen signaling pathway 💬
1件: PGR 💬 D01217 💬 Dydrogesterone 1件: 13 💬
79 Estrogen signaling pathway 💬
1件: PGR 💬 D00950 💬 Levonorgestrel 1件: 13 💬
80 Estrogen signaling pathway 💬
1件: PGR 💬 D00951 💬 Medroxyprogesterone acetate 6件: 13, 35, 46, 49, 51, 60 💬
81 Estrogen signaling pathway 💬
1件: PGR 💬 D08166 💬 Medroxyprogesterone acetate 6件: 13, 35, 46, 49, 51, 60 💬
82 Estrogen signaling pathway 💬
1件: PGR 💬 D00952 💬 Megestrol acetate 1件: 76 💬
83 Estrogen signaling pathway 💬
1件: PGR 💬 D08167 💬 Megestrol acetate 1件: 76 💬
84 Estrogen signaling pathway 💬
1件: PGR 💬 D00585 💬 Mifepristone 1件: 75 💬
85 Estrogen signaling pathway 💬
1件: PGR 💬 D07222 💬 Nomegestrol 1件: 13 💬
86 Estrogen signaling pathway 💬
1件: PGR 💬 D08281 💬 Nomegestrol acetate 1件: 13 💬
87 Estrogen signaling pathway 💬
1件: PGR 💬 D00182 💬 Norethisterone 4件: 13, 46, 49, 299 💬
88 Estrogen signaling pathway 💬
1件: PGR 💬 D00953 💬 Norethisterone 4件: 13, 46, 49, 299 💬
89 Estrogen signaling pathway 💬
1件: PGR 💬 D05209 💬 Norgestimate 1件: 299 💬
90 Estrogen signaling pathway 💬
1件: PGR 💬 D00066 💬 Progesterone 1件: 76 💬
91 Estrogen signaling pathway 💬
1件: PGR 💬 D09567 💬 Ulipristal 1件: 10 💬
92 Estrogen signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
93 Estrogen signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
94 Estrogen signaling pathway 💬
1件: PRKCD 💬 D09671 💬 Sotrastaurin 1件: 97 💬
95 Estrogen signaling pathway 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
96 Estrogen signaling pathway 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
97 Estrogen signaling pathway 💬
1件: RARA 💬 D02754 💬 Acitretin 1件: 37 💬
98 Estrogen signaling pathway 💬
1件: RARA 💬 D02815 💬 Alitretinoin 1件: 49 💬
99 Estrogen signaling pathway 💬
1件: RARA 💬 D04162 💬 Fenretinide 1件: 299 💬
100 Estrogen signaling pathway 💬
1件: RARA 💬 D00348 💬 Isotretinoin 4件: 36, 39, 159, 160 💬
101 Estrogen signaling pathway 💬
1件: RARA 💬 D01418 💬 Tamibarotene 2件: 26, 96 💬
102 Estrogen signaling pathway 💬
1件: RARA 💬 D00094 💬 Tretinoin 6件:  2 , 62, 63, 75, 94, 231 💬
103 Estrogen signaling pathway 💬
1件: RARA 💬 D06543 💬 Vitamin A 3件: 13, 53, 90 💬
104 Estrogen signaling pathway 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
105 Estrogen signaling pathway 💬
1件: SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
106 Estrogen signaling pathway 💬
1件: SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
107 Estrogen signaling pathway 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬