Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
2 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
3 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
4 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
5 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
6 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
7 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
8 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
9 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
10 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
11 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
12 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
13 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
14 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
15 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
16 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
17 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
18 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
19 GnRH secretion 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D01303 💬 Flunarizine 4件: 58, 86, 149, 215 💬
20 GnRH secretion 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D07971 💬 Flunarizine 4件: 58, 86, 149, 215 💬
21 GnRH secretion 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00399 💬 Valproic acid 17件:  2 ,  3 ,  5 ,  6 , 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331 💬
22 GnRH secretion 💬
3件: CACNA1G, CACNA1H, CACNA1I 💬 D00538 💬 Zonisamide 1件:  6  💬
23 GnRH secretion 💬
1件: ESR2 💬 D00962 💬 Clomifene 1件: 74 💬
24 GnRH secretion 💬
1件: ESR2 💬 D07726 💬 Clomifene 1件: 74 💬
25 GnRH secretion 💬
1件: ESR2 💬 D11513 💬 Estetrol 1件: 53 💬
26 GnRH secretion 💬
1件: ESR2 💬 D11514 💬 Estetrol 1件: 53 💬
27 GnRH secretion 💬
1件: ESR2 💬 D00105 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
28 GnRH secretion 💬
1件: ESR2 💬 D01413 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
29 GnRH secretion 💬
1件: ESR2 💬 D01617 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
30 GnRH secretion 💬
1件: ESR2 💬 D01953 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
31 GnRH secretion 💬
1件: ESR2 💬 D04061 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
32 GnRH secretion 💬
1件: ESR2 💬 D04063 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
33 GnRH secretion 💬
1件: ESR2 💬 D04064 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
34 GnRH secretion 💬
1件: ESR2 💬 D04065 💬 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299 💬
35 GnRH secretion 💬
1件: ESR2 💬 D01413 💬 Estradiol valerate 1件: 65 💬
36 GnRH secretion 💬
1件: ESR2 💬 D00185 💬 Estriol 2件: 13, 227 💬
37 GnRH secretion 💬
1件: ESR2 💬 D01986 💬 Estriol 2件: 13, 227 💬
38 GnRH secretion 💬
1件: ESR2 💬 D01161 💬 Fulvestrant 2件: 49, 86 💬
39 GnRH secretion 💬
1件: ESR2 💬 D00575 💬 Mestranol 2件: 46, 49 💬
40 GnRH secretion 💬
1件: ESR2 💬 D08409 💬 Prasterone 6件: 49, 53, 83, 86, 96, 113 💬
41 GnRH secretion 💬
1件: ESR2 💬 D02217 💬 Raloxifene 1件: 46 💬
42 GnRH secretion 💬
1件: ESR2 💬 D08465 💬 Raloxifene 1件: 46 💬
43 GnRH secretion 💬
1件: ESR2 💬 D00966 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
44 GnRH secretion 💬
1件: ESR2 💬 D08559 💬 Tamoxifen 4件:  2 , 86, 113, 227 💬
45 GnRH secretion 💬
2件: GABBR1, GABBR2 💬 D09791 💬 Arbaclofen 2件: 13, 206 💬
46 GnRH secretion 💬
2件: GABBR1, GABBR2 💬 D08861 💬 Arbaclofen Placarbil 1件: 13 💬
47 GnRH secretion 💬
2件: GABBR1, GABBR2 💬 D00241 💬 Baclofen 7件:  2 , 10, 13, 18, 65, 149, 206 💬
48 GnRH secretion 💬
1件: KCNJ11 💬 D00294 💬 Diazoxide 2件: 13, 193 💬
49 GnRH secretion 💬
1件: KCNJ11 💬 D00418 💬 Minoxidil 1件: 179 💬
50 GnRH secretion 💬
1件: KCNJ11 💬 D00594 💬 Repaglinide 3件:  6 , 21, 299 💬
51 GnRH secretion 💬
3件: KCNJ11, KCNJ3, KCNJ5 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
52 GnRH secretion 💬
3件: KCNJ11, KCNJ3, KCNJ5 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
53 GnRH secretion 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
54 GnRH secretion 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
55 GnRH secretion 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
56 GnRH secretion 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
57 GnRH secretion 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
58 GnRH secretion 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
59 GnRH secretion 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
60 GnRH secretion 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬