Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Osteoclast differentiation 💬
1件: BTK 💬 D10893 💬 Acalabrutinib 2件: 46, 61 💬
2 Osteoclast differentiation 💬
1件: BTK 💬 D11478 💬 Branebrutinib 3件: 46, 49, 53 💬
3 Osteoclast differentiation 💬
1件: BTK 💬 D11457 💬 Fenebrutinib 1件: 13 💬
4 Osteoclast differentiation 💬
1件: BTK 💬 D10223 💬 Ibrutinib 3件: 28, 60, 61 💬
5 Osteoclast differentiation 💬
1件: BTK 💬 D12160 💬 Orelabrutinib 3件: 13, 61, 63 💬
6 Osteoclast differentiation 💬
1件: BTK 💬 D11422 💬 Zanubrutinib 2件: 300, 331 💬
7 Osteoclast differentiation 💬
1件: CSF1 💬 D06402 💬 Sunitinib 2件: 28, 34 💬
8 Osteoclast differentiation 💬
1件: CSF1 💬 D08552 💬 Sunitinib 2件: 28, 34 💬
9 Osteoclast differentiation 💬
1件: CSF1R 💬 D11270 💬 Pexidartinib 1件: 34 💬
10 Osteoclast differentiation 💬
2件: FYN, LCK 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
11 Osteoclast differentiation 💬
2件: FYN, LCK 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
12 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D11082 💬 Anifrolumab 2件: 46, 49 💬
13 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D03305 💬 Interferon alfa 6件: 13, 25, 26, 28, 56, 96 💬
14 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D00745 💬 Interferon alfa-2a 1件: 56 💬
15 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D02745 💬 Interferon alfa-2b 2件: 25, 34 💬
16 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D04554 💬 Interferon beta-1a 4件: 13, 26, 96, 97 💬
17 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D00746 💬 Interferon beta-1b 1件: 13 💬
18 Osteoclast differentiation 💬
2件: IFNAR1, IFNAR2 💬 D10483 💬 Peginterferon beta-1a 1件: 13 💬
19 Osteoclast differentiation 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
20 Osteoclast differentiation 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
21 Osteoclast differentiation 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
22 Osteoclast differentiation 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
23 Osteoclast differentiation 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
24 Osteoclast differentiation 💬
3件: IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
25 Osteoclast differentiation 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
26 Osteoclast differentiation 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
27 Osteoclast differentiation 💬
1件: IL1R1 💬 D02934 💬 Anakinra 19件:  2 , 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬
28 Osteoclast differentiation 💬
1件: JAK1 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
29 Osteoclast differentiation 💬
1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
30 Osteoclast differentiation 💬
1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
31 Osteoclast differentiation 💬
1件: JAK1 💬 D10653 💬 Peficitinib 1件: 46 💬
32 Osteoclast differentiation 💬
1件: JAK1 💬 D09959 💬 Ruxolitinib 1件: 228 💬
33 Osteoclast differentiation 💬
1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
34 Osteoclast differentiation 💬
2件: JAK1, TYK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
35 Osteoclast differentiation 💬
1件: MAP2K1 💬 D10604 💬 Binimetinib 1件: 34 💬
36 Osteoclast differentiation 💬
1件: MAP2K1 💬 D10405 💬 Cobimetinib 1件: 280 💬
37 Osteoclast differentiation 💬
1件: MAP2K1 💬 D09666 💬 Selumetinib 1件: 34 💬
38 Osteoclast differentiation 💬
1件: MAP2K1 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
39 Osteoclast differentiation 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
40 Osteoclast differentiation 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
41 Osteoclast differentiation 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
42 Osteoclast differentiation 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
43 Osteoclast differentiation 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
44 Osteoclast differentiation 💬
1件: PPARG 💬 D11603 💬 Leriglitazone 1件: 20 💬
45 Osteoclast differentiation 💬
1件: PPARG 💬 D00945 💬 Pioglitazone 17件:  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
46 Osteoclast differentiation 💬
1件: PPARG 💬 D08378 💬 Pioglitazone 17件:  2 ,  6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬
47 Osteoclast differentiation 💬
1件: PPARG 💬 D00596 💬 Rosiglitazone 5件: 46, 75, 97, 222, 265 💬
48 Osteoclast differentiation 💬
1件: PPARG 💬 D08491 💬 Rosiglitazone 5件: 46, 75, 97, 222, 265 💬
49 Osteoclast differentiation 💬
1件: PPARG 💬 D11256 💬 Seladelpar 2件: 93, 94 💬
50 Osteoclast differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
51 Osteoclast differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
52 Osteoclast differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
53 Osteoclast differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
54 Osteoclast differentiation 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
55 Osteoclast differentiation 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
56 Osteoclast differentiation 💬
1件: SYK 💬 D09347 💬 Fostamatinib 4件: 46, 49, 61, 66 💬
57 Osteoclast differentiation 💬
2件: TGFB1, TGFB2 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
58 Osteoclast differentiation 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
59 Osteoclast differentiation 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
60 Osteoclast differentiation 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
61 Osteoclast differentiation 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
62 Osteoclast differentiation 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
63 Osteoclast differentiation 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
64 Osteoclast differentiation 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
65 Osteoclast differentiation 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
66 Osteoclast differentiation 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
67 Osteoclast differentiation 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
68 Osteoclast differentiation 💬
1件: TNFSF11 💬 D03684 💬 Denosumab 7件: 46, 50, 93, 95, 96, 274, 299 💬
69 Osteoclast differentiation 💬
1件: TYK2 💬 D11817 💬 Deucravacitinib 2件: 96, 97 💬