Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D00227 💬 Aminophylline 1件: 63 💬
2 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D05429 💬 Aminophylline 1件: 63 💬
3 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
4 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
5 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D00371 💬 Theophylline 2件: 236, 299 💬
6 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D01712 💬 Theophylline 2件: 236, 299 💬
7 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D02017 💬 Theophylline 2件: 236, 299 💬
8 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D06103 💬 Theophylline 2件: 236, 299 💬
9 Sphingolipid signaling pathway 💬
1件: ADORA1 💬 D06104 💬 Theophylline 2件: 236, 299 💬
10 Sphingolipid signaling pathway 💬
2件: ADORA1, ADORA3 💬 D00045 💬 Adenosine 3件: 13, 58, 65 💬
11 Sphingolipid signaling pathway 💬
2件: ADORA1, ADORA3 💬 D02769 💬 Adenosine phosphate 1件: 46 💬
12 Sphingolipid signaling pathway 💬
1件: ADORA3 💬 D10971 💬 Piclidenoson 1件: 46 💬
13 Sphingolipid signaling pathway 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
14 Sphingolipid signaling pathway 💬
1件: FCER1A 💬 D05251 💬 Omalizumab 7件: 46, 53, 65, 98, 162, 226, 299 💬
15 Sphingolipid signaling pathway 💬
1件: FYN 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
16 Sphingolipid signaling pathway 💬
1件: FYN 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
17 Sphingolipid signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
18 Sphingolipid signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
19 Sphingolipid signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
20 Sphingolipid signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
21 Sphingolipid signaling pathway 💬
1件: MAP3K5 💬 D10988 💬 Selonsertib 1件: 86 💬
22 Sphingolipid signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
23 Sphingolipid signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
24 Sphingolipid signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
25 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D00729 💬 Loperamide 2件: 13, 97 💬
26 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D07113 💬 Loperamide 2件: 13, 97 💬
27 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D08144 💬 Loperamide 2件: 13, 97 💬
28 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D00843 💬 Nalbuphine 1件: 85 💬
29 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D08246 💬 Nalbuphine 1件: 85 💬
30 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D05111 💬 Nalmefene 1件:  6  💬
31 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D01340 💬 Naloxone 2件:  6 , 226 💬
32 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D08249 💬 Naloxone 2件:  6 , 226 💬
33 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D02095 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
34 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D05113 💬 Naltrexone 13件:  6 , 10, 13, 40, 41, 42, 43, 44, 45, 46, 96, 97, 226 💬
35 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D03783 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
36 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D05312 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
37 Sphingolipid signaling pathway 💬
1件: OPRD1 💬 D05462 💬 Oxycodone 7件:  6 , 13, 46, 70, 226, 231, 298 💬
38 Sphingolipid signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
39 Sphingolipid signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
40 Sphingolipid signaling pathway 💬
1件: PRKCE 💬 D09671 💬 Sotrastaurin 1件: 97 💬
41 Sphingolipid signaling pathway 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
42 Sphingolipid signaling pathway 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
43 Sphingolipid signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
44 Sphingolipid signaling pathway 💬
2件: ROCK1, ROCK2 💬 D07941 💬 Fasudil 4件:  2 ,  5 ,  7 , 51 💬
45 Sphingolipid signaling pathway 💬
1件: ROCK2 💬 D11815 💬 Belumosudil 1件: 51 💬
46 Sphingolipid signaling pathway 💬
1件: S1PR1 💬 D11283 💬 Cenerimod 1件: 49 💬
47 Sphingolipid signaling pathway 💬
1件: S1PR1 💬 D10001 💬 Fingolimod 3件: 13, 14, 156 💬
48 Sphingolipid signaling pathway 💬
1件: S1PR1 💬 D11215 💬 Ponesimod 1件: 13 💬
49 Sphingolipid signaling pathway 💬
5件: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 D10930 💬 Etrasimod 3件: 96, 97, 98 💬
50 Sphingolipid signaling pathway 💬
5件: S1PR1, S1PR2, S1PR3, S1PR4, S1PR5 💬 D10968 💬 Ozanimod 3件: 13, 96, 97 💬
51 Sphingolipid signaling pathway 💬
2件: S1PR1, S1PR5 💬 D11460 💬 Siponimod 2件: 13, 50 💬
52 Sphingolipid signaling pathway 💬
1件: SMPD1 💬 D10820 💬 Olipudase alfa 1件: 19 💬
53 Sphingolipid signaling pathway 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
54 Sphingolipid signaling pathway 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
55 Sphingolipid signaling pathway 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
56 Sphingolipid signaling pathway 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
57 Sphingolipid signaling pathway 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
58 Sphingolipid signaling pathway 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
59 Sphingolipid signaling pathway 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
60 Sphingolipid signaling pathway 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
61 Sphingolipid signaling pathway 💬
1件: TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
62 Sphingolipid signaling pathway 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
63 Sphingolipid signaling pathway 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬