Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 T cell receptor signaling pathway 💬
3件: CD3D, CD3E, CD3G 💬 D05092 💬 Muromonab 3件: 60, 96, 97 💬
2 T cell receptor signaling pathway 💬
3件: CD3D, CD3E, CD3G 💬 D08959 💬 Otelixizumab 1件: 46 💬
3 T cell receptor signaling pathway 💬
3件: CD3D, CD3E, CD3G 💬 D06314 💬 Visilizumab 2件: 96, 97 💬
4 T cell receptor signaling pathway 💬
1件: CD3E 💬 D11463 💬 Mosunetuzumab 1件: 49 💬
5 T cell receptor signaling pathway 💬
1件: CD40LG 💬 D06193 💬 Toralizumab 1件: 63 💬
6 T cell receptor signaling pathway 💬
1件: CDK4 💬 D10688 💬 Abemaciclib 1件: 34 💬
7 T cell receptor signaling pathway 💬
1件: CSF2 💬 D11343 💬 Otilimab 2件: 46, 256 💬
8 T cell receptor signaling pathway 💬
1件: CTLA4 💬 D04603 💬 Ipilimumab 1件: 159 💬
9 T cell receptor signaling pathway 💬
1件: CTLA4 💬 D06657 💬 Tremelimumab 1件: 96 💬
10 T cell receptor signaling pathway 💬
2件: FYN, LCK 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
11 T cell receptor signaling pathway 💬
2件: FYN, LCK 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
12 T cell receptor signaling pathway 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
13 T cell receptor signaling pathway 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
14 T cell receptor signaling pathway 💬
2件: IL10, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
15 T cell receptor signaling pathway 💬
1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
16 T cell receptor signaling pathway 💬
1件: IL5 💬 D04923 💬 Mepolizumab 4件: 44, 45, 98, 162 💬
17 T cell receptor signaling pathway 💬
1件: IL5 💬 D08985 💬 Reslizumab 2件: 44, 98 💬
18 T cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
19 T cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
20 T cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
21 T cell receptor signaling pathway 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
22 T cell receptor signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
23 T cell receptor signaling pathway 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
24 T cell receptor signaling pathway 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
25 T cell receptor signaling pathway 💬
1件: PDCD1 💬 D10316 💬 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159 💬
26 T cell receptor signaling pathway 💬
1件: PDCD1 💬 D10574 💬 Pembrolizumab 2件: 25, 285 💬
27 T cell receptor signaling pathway 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
28 T cell receptor signaling pathway 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
29 T cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
30 T cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
31 T cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
32 T cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
33 T cell receptor signaling pathway 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
34 T cell receptor signaling pathway 💬
1件: PRKCQ 💬 D09671 💬 Sotrastaurin 1件: 97 💬
35 T cell receptor signaling pathway 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
36 T cell receptor signaling pathway 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
37 T cell receptor signaling pathway 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
38 T cell receptor signaling pathway 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
39 T cell receptor signaling pathway 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
40 T cell receptor signaling pathway 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
41 T cell receptor signaling pathway 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
42 T cell receptor signaling pathway 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
43 T cell receptor signaling pathway 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
44 T cell receptor signaling pathway 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
45 T cell receptor signaling pathway 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
46 T cell receptor signaling pathway 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
47 T cell receptor signaling pathway 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬