Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D00528 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
2 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D01453 💬 Caffeine 9件:  2 ,  6 , 13, 21, 46, 78, 96, 97, 265 💬
3 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D04641 💬 Istradefylline 1件:  6  💬
4 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D09717 💬 Preladenant 1件:  6  💬
5 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D05711 💬 Regadenoson 1件: 58 💬
6 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D02017 💬 Theophylline 2件: 236, 299 💬
7 Vascular smooth muscle contraction 💬
1件: ADORA2A 💬 D10174 💬 Tozadenant 1件:  6  💬
8 Vascular smooth muscle contraction 💬
2件: ADORA2A, ADORA2B 💬 D00045 💬 Adenosine 3件: 13, 58, 65 💬
9 Vascular smooth muscle contraction 💬
2件: ADORA2A, ADORA2B 💬 D02769 💬 Adenosine phosphate 1件: 46 💬
10 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D00227 💬 Aminophylline 1件: 63 💬
11 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D05429 💬 Aminophylline 1件: 63 💬
12 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D00371 💬 Theophylline 2件: 236, 299 💬
13 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D01712 💬 Theophylline 2件: 236, 299 💬
14 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D06103 💬 Theophylline 2件: 236, 299 💬
15 Vascular smooth muscle contraction 💬
1件: ADORA2B 💬 D06104 💬 Theophylline 2件: 236, 299 💬
16 Vascular smooth muscle contraction 💬
1件: ADRA1A 💬 D01692 💬 Alfuzosin 1件: 13 💬
17 Vascular smooth muscle contraction 💬
1件: ADRA1A 💬 D07124 💬 Alfuzosin 1件: 13 💬
18 Vascular smooth muscle contraction 💬
1件: ADRA1A 💬 D01965 💬 Silodosin 2件:  6 , 13 💬
19 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00636 💬 Amiodarone 2件: 28, 127 💬
20 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D02910 💬 Amiodarone 2件: 28, 127 💬
21 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00255 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
22 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D03415 💬 Carvedilol 5件:  6 , 57, 86, 113, 210 💬
23 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D02349 💬 Dipivefrin 1件:  6  💬
24 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00608 💬 Doxazosin 2件: 57, 67 💬
25 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D07874 💬 Doxazosin 2件: 57, 67 💬
26 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D01277 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬
27 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00124 💬 Ephedrine 1件: 11 💬
28 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00095 💬 Epinephrine 3件: 46, 70, 96 💬
29 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00996 💬 Epinephrine 3件: 46, 70, 96 💬
30 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D02149 💬 Epinephrine 3件: 46, 70, 96 💬
31 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D02268 💬 Ergoloid mesylate 2件:  6 , 206 💬
32 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08064 💬 Ifenprodil 1件: 85 💬
33 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00680 💬 Methylergometrine 3件: 118, 280, 288 💬
34 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08207 💬 Methylergometrine 3件: 118, 280, 288 💬
35 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D01307 💬 Midodrine 3件:  6 , 17, 58 💬
36 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08220 💬 Midodrine 3件:  6 , 17, 58 💬
37 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00076 💬 Norepinephrine 1件: 22 💬
38 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D05206 💬 Norepinephrine 1件: 22 💬
39 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00454 💬 Olanzapine 2件:  2 ,  8  💬
40 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D06623 💬 Olanzapine 2件:  2 ,  8  💬
41 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00511 💬 Phenylephrine 1件: 22 💬
42 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08365 💬 Phenylephrine 1件: 22 💬
43 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00485 💬 Pseudoephedrine 1件: 17 💬
44 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D05648 💬 Pseudoephedrine 1件: 17 💬
45 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D05649 💬 Pseudoephedrine 1件: 17 💬
46 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08449 💬 Pseudoephedrine 1件: 17 💬
47 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D00610 💬 Terazosin 1件:  6  💬
48 Vascular smooth muscle contraction 💬
3件: ADRA1A, ADRA1B, ADRA1D 💬 D08569 💬 Terazosin 1件:  6  💬
49 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00150 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
50 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D02014 💬 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224 💬
51 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00522 💬 Candesartan 2件: 58, 67 💬
52 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00522 💬 Candesartan cilexetil 1件: 67 💬
53 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00626 💬 Candesartan cilexetil 1件: 67 💬
54 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
55 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00357 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
56 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D08146 💬 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 💬
57 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00627 💬 Telmisartan 2件: 66, 67 💬
58 Vascular smooth muscle contraction 💬
1件: AGTR1 💬 D00400 💬 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224 💬
59 Vascular smooth muscle contraction 💬
2件: AGTR1, EDNRA 💬 D11776 💬 Sparsentan 3件: 66, 218, 222 💬
60 Vascular smooth muscle contraction 💬
1件: AVPR1A 💬 D01236 💬 Conivaptan 1件: 86 💬
61 Vascular smooth muscle contraction 💬
1件: AVPR1A 💬 D07748 💬 Conivaptan 1件: 86 💬
62 Vascular smooth muscle contraction 💬
2件: AVPR1A, AVPR1B 💬 D06672 💬 Terlipressin 1件: 299 💬
63 Vascular smooth muscle contraction 💬
2件: AVPR1A, AVPR1B 💬 D00101 💬 Vasopressin 1件: 210 💬
64 Vascular smooth muscle contraction 💬
1件: BRAF 💬 D10064 💬 Dabrafenib 1件: 34 💬
65 Vascular smooth muscle contraction 💬
2件: BRAF, RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
66 Vascular smooth muscle contraction 💬
2件: BRAF, RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
67 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
68 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
69 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
70 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01173 💬 Cilnidipine 1件: 67 💬
71 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
72 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
73 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
74 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00349 💬 Isradipine 1件:  6  💬
75 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
76 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
77 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
78 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D01908 💬 Nilvadipine 1件: 90 💬
79 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
80 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
81 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D08441 💬 Propiverine 1件: 226 💬
82 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
83 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
84 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
85 Vascular smooth muscle contraction 💬
1件: CALCA 💬 D11055 💬 Fremanezumab 2件: 124, 226 💬
86 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D07077 💬 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211 💬
87 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D01227 💬 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
88 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D07538 💬 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
89 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D10135 💬 Macitentan 5件: 51, 85, 86, 88, 210 💬
90 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D07171 💬 Sitaxentan 1件: 86 💬
91 Vascular smooth muscle contraction 💬
1件: EDNRA 💬 D07741 💬 Zibotentan 1件: 51 💬
92 Vascular smooth muscle contraction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D00517 💬 Amyl Nitrite 1件: 58 💬
93 Vascular smooth muscle contraction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 D09572 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬
94 Vascular smooth muscle contraction 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
95 Vascular smooth muscle contraction 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
96 Vascular smooth muscle contraction 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
97 Vascular smooth muscle contraction 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
98 Vascular smooth muscle contraction 💬
1件: NPR1 💬 D05147 💬 Nesiritide 2件: 46, 58 💬
99 Vascular smooth muscle contraction 💬
2件: NPR1, NPR2 💬 D04051 💬 Erythrityl tetranitrate 1件: 46 💬
100 Vascular smooth muscle contraction 💬
1件: NPR2 💬 D11190 💬 Vosoritide 1件: 276 💬
101 Vascular smooth muscle contraction 💬
4件: PRKCD, PRKCE, PRKCH, PRKCQ 💬 D09671 💬 Sotrastaurin 1件: 97 💬
102 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D02720 💬 Beraprost 1件: 86 💬
103 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D00106 💬 Epoprostenol 1件: 86 💬
104 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D01337 💬 Epoprostenol 1件: 86 💬
105 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D01385 💬 Ibudilast 2件:  2 , 13 💬
106 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D02721 💬 Iloprost 4件: 51, 84, 85, 86 💬
107 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D10725 💬 Ralinepag 1件: 86 💬
108 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D09994 💬 Selexipag 6件: 47, 51, 70, 84, 86, 88 💬
109 Vascular smooth muscle contraction 💬
1件: PTGIR 💬 D06213 💬 Treprostinil 6件: 51, 84, 85, 86, 88, 210 💬
110 Vascular smooth muscle contraction 💬
2件: ROCK1, ROCK2 💬 D07941 💬 Fasudil 4件:  2 ,  5 ,  7 , 51 💬
111 Vascular smooth muscle contraction 💬
1件: ROCK2 💬 D11815 💬 Belumosudil 1件: 51 💬