Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
2 CPS1 6件: Arginine biosynthesis 💬, Alanine, aspartate and glutamate metabolism 💬, Nitrogen metabolism 💬, Metabolic pathways 💬, Carbon metabolism 💬, Biosynthesis of amino acids 💬 D07130 Carglumic acid 3件: 245, 246, 251
3 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
4 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
5 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
6 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
7 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
8 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
9 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
10 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
11 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
12 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
13 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
14 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
15 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
16 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246
17 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D07546 Bucladesine 1件: 246