Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 RGMA 2件: TGF-beta signaling pathway 💬, Axon guidance 💬 D11355 Elezanumab 1件: 13
2 RTN4 1件: Alzheimer disease 💬 D10331 Ozanezumab 1件: 2
3 RAF1 83件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, Axon guidance 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D06272 Sorafenib 2件: 34, 86
4 RAF1 83件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Cellular senescence 💬, Vascular smooth muscle contraction 💬, Axon guidance 💬, VEGF signaling pathway 💬, Apelin signaling pathway 💬, Focal adhesion 💬, Gap junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Neutrophil extracellular trap formation 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Melanogenesis 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, GnRH secretion 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Salmonella infection 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D08524 Sorafenib 2件: 34, 86
5 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
6 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00348 Isotretinoin 4件: 36, 39, 159, 160
7 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D01418 Tamibarotene 2件: 26, 96
8 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D02754 Acitretin 1件: 37
9 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D02815 Alitretinoin 1件: 49
10 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D04162 Fenretinide 1件: 299
11 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D06543 Vitamin A 3件: 13, 53, 90
12 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
13 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D00348 Isotretinoin 4件: 36, 39, 159, 160
14 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D02754 Acitretin 1件: 37
15 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D02815 Alitretinoin 1件: 49
16 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D04162 Fenretinide 1件: 299
17 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D06543 Vitamin A 3件: 13, 53, 90
18 RELA 76件: Antifolate resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, NF-kappa B signaling pathway 💬, HIF-1 signaling pathway 💬, Sphingolipid signaling pathway 💬, Mitophagy - animal 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Longevity regulating pathway 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, TNF signaling pathway 💬, Neurotrophin signaling pathway 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, Relaxin signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Pancreatic cancer 💬, Prostate cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Small cell lung cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬, Diabetic cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D12181 Edasalonexent 1件: 113
19 REN 3件: Renin-angiotensin system 💬, Renin secretion 💬, Diabetic cardiomyopathy 💬 D03208 Aliskiren 3件: 66, 167, 222
20 RET 5件: Calcium signaling pathway 💬, Pathways in cancer 💬, Thyroid cancer 💬, Non-small cell lung cancer 💬, Central carbon metabolism in cancer 💬 D06272 Sorafenib 2件: 34, 86
21 RET 5件: Calcium signaling pathway 💬, Pathways in cancer 💬, Thyroid cancer 💬, Non-small cell lung cancer 💬, Central carbon metabolism in cancer 💬 D06402 Sunitinib 2件: 28, 34
22 RET 5件: Calcium signaling pathway 💬, Pathways in cancer 💬, Thyroid cancer 💬, Non-small cell lung cancer 💬, Central carbon metabolism in cancer 💬 D08524 Sorafenib 2件: 34, 86
23 RET 5件: Calcium signaling pathway 💬, Pathways in cancer 💬, Thyroid cancer 💬, Non-small cell lung cancer 💬, Central carbon metabolism in cancer 💬 D08552 Sunitinib 2件: 28, 34
24 ROCK1 20件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, Sphingolipid signaling pathway 💬, Vascular smooth muscle contraction 💬, TGF-beta signaling pathway 💬, Axon guidance 💬, Focal adhesion 💬, Tight junction 💬, Platelet activation 💬, Leukocyte transendothelial migration 💬, Regulation of actin cytoskeleton 💬, Oxytocin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Yersinia infection 💬, Human cytomegalovirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬 D07941 Fasudil 4件: 2, 5, 7, 51
25 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01370 Cladribine 3件: 11, 13, 94
26 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01907 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
27 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D03546 Clofarabine 9件: 19, 20, 40, 46, 49, 60, 96, 234, 326
28 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D07966 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
29 RRM2 6件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬, p53 signaling pathway 💬 D00341 Hydroxyurea 8件: 3, 13, 19, 20, 65, 85, 86, 284
30 RXRA 17件: PPAR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Non-alcoholic fatty liver disease 💬, Bile secretion 💬, Hepatitis C 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02754 Acitretin 1件: 37
31 RXRA 17件: PPAR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Non-alcoholic fatty liver disease 💬, Bile secretion 💬, Hepatitis C 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02815 Alitretinoin 1件: 49
32 RXRA 17件: PPAR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Non-alcoholic fatty liver disease 💬, Bile secretion 💬, Hepatitis C 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
33 RXRB 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02754 Acitretin 1件: 37
34 RXRB 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02815 Alitretinoin 1件: 49
35 RXRB 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
36 RXRG 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02754 Acitretin 1件: 37
37 RXRG 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D02815 Alitretinoin 1件: 49
38 RXRG 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
39 ROCK2 21件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, Sphingolipid signaling pathway 💬, Vascular smooth muscle contraction 💬, Wnt signaling pathway 💬, Axon guidance 💬, Focal adhesion 💬, Tight junction 💬, Platelet activation 💬, Leukocyte transendothelial migration 💬, Regulation of actin cytoskeleton 💬, Oxytocin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Yersinia infection 💬, Human cytomegalovirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Lipid and atherosclerosis 💬 D07941 Fasudil 4件: 2, 5, 7, 51
40 ROCK2 21件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, Sphingolipid signaling pathway 💬, Vascular smooth muscle contraction 💬, Wnt signaling pathway 💬, Axon guidance 💬, Focal adhesion 💬, Tight junction 💬, Platelet activation 💬, Leukocyte transendothelial migration 💬, Regulation of actin cytoskeleton 💬, Oxytocin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Yersinia infection 💬, Human cytomegalovirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Lipid and atherosclerosis 💬 D11815 Belumosudil 1件: 51