Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 BCL2 43件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, NF-kappa B signaling pathway 💬, HIF-1 signaling pathway 💬, Sphingolipid signaling pathway 💬, p53 signaling pathway 💬, Autophagy - animal 💬, Protein processing in endoplasmic reticulum 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Apoptosis - multiple species 💬, Necroptosis 💬, Adrenergic signaling in cardiomyocytes 💬, Hedgehog signaling pathway 💬, Focal adhesion 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Estrogen signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Amyotrophic lateral sclerosis 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Salmonella infection 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Prostate cancer 💬, Small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D10679 Venetoclax 1件: 28
2 BMPR2 7件: Cytokine-cytokine receptor interaction 💬, TGF-beta signaling pathway 💬, Axon guidance 💬, Hippo signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, MicroRNAs in cancer 💬, Fluid shear stress and atherosclerosis 💬 D03779 Dibotermin alfa 1件: 34
3 BRAF 44件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, FoxO signaling pathway 💬, mTOR signaling pathway 💬, Vascular smooth muscle contraction 💬, Focal adhesion 💬, Natural killer cell mediated cytotoxicity 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Hepatitis C 💬, Hepatitis B 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬 D06272 Sorafenib 2件: 34, 86
4 BRAF 44件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, FoxO signaling pathway 💬, mTOR signaling pathway 💬, Vascular smooth muscle contraction 💬, Focal adhesion 💬, Natural killer cell mediated cytotoxicity 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Hepatitis C 💬, Hepatitis B 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬 D08524 Sorafenib 2件: 34, 86
5 BRAF 44件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, FoxO signaling pathway 💬, mTOR signaling pathway 💬, Vascular smooth muscle contraction 💬, Focal adhesion 💬, Natural killer cell mediated cytotoxicity 💬, Long-term potentiation 💬, Neurotrophin signaling pathway 💬, Serotonergic synapse 💬, Long-term depression 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Alcoholism 💬, Hepatitis C 💬, Hepatitis B 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Thyroid cancer 💬, Melanoma 💬, Bladder cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬 D10064 Dabrafenib 1件: 34
6 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D10223 Ibrutinib 3件: 28, 60, 61
7 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D10893 Acalabrutinib 2件: 46, 61
8 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11422 Zanubrutinib 2件: 300, 331
9 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11457 Fenebrutinib 1件: 13
10 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11478 Branebrutinib 3件: 46, 49, 53
11 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D12160 Orelabrutinib 3件: 13, 61, 63