Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 HDAC6 💬 4件: Neutrophil extracellular trap formation, Amyotrophic lateral sclerosis, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
2 HDAC5 💬 5件: Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Vorinostat 💬 Vorinostat 2件: 75, 96 💬
3 HRH3 💬 1件: Neuroactive ligand-receptor interaction Bavisant 💬 Bavisant 1件: 6 💬
4 HRH3 💬 1件: Neuroactive ligand-receptor interaction Pitolisant 💬 Pitolisant 3件: 6, 113, 193 💬
5 HTR3C 💬 2件: Serotonergic synapse, Taste transduction Clozapine 💬 Clozapine 1件: 6 💬
6 HTR3C 💬 2件: Serotonergic synapse, Taste transduction Ondansetron 💬 Ondansetron 3件: 6, 97, 107 💬
7 HTR3C 💬 2件: Serotonergic synapse, Taste transduction Dolasetron 💬 Dolasetron 1件: 46 💬
8 HTR3C 💬 2件: Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
9 HTR3D 💬 2件: Serotonergic synapse, Taste transduction Clozapine 💬 Clozapine 1件: 6 💬
10 HTR3D 💬 2件: Serotonergic synapse, Taste transduction Ondansetron 💬 Ondansetron 3件: 6, 97, 107 💬
11 HTR3D 💬 2件: Serotonergic synapse, Taste transduction Dolasetron 💬 Dolasetron 1件: 46 💬
12 HTR3D 💬 2件: Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
13 HTR3E 💬 2件: Serotonergic synapse, Taste transduction Clozapine 💬 Clozapine 1件: 6 💬
14 HTR3E 💬 2件: Serotonergic synapse, Taste transduction Ondansetron 💬 Ondansetron 3件: 6, 97, 107 💬
15 HTR3E 💬 2件: Serotonergic synapse, Taste transduction Dolasetron 💬 Dolasetron 1件: 46 💬
16 HTR3E 💬 2件: Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
17 HCRTR1 💬 1件: Neuroactive ligand-receptor interaction Suvorexant 💬 Suvorexant 3件: 5, 6, 13 💬
18 HCRTR2 💬 1件: Neuroactive ligand-receptor interaction Suvorexant 💬 Suvorexant 3件: 5, 6, 13 💬
19 HDAC1 💬 15件: Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Vorinostat 💬 Vorinostat 2件: 75, 96 💬
20 HDAC2 💬 15件: Cell cycle, Longevity regulating pathway - multiple species, Notch signaling pathway, Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Huntington disease, Amphetamine addiction, Alcoholism, Human papillomavirus infection, Epstein-Barr virus infection, Pathways in cancer, Transcriptional misregulation in cancer, Viral carcinogenesis, MicroRNAs in cancer, Chronic myeloid leukemia Vorinostat 💬 Vorinostat 2件: 75, 96 💬
21 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Lovastatin 💬 Lovastatin 11件: 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310 💬
22 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Simvastatin 💬 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310 💬
23 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
24 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Fluvastatin 💬 Fluvastatin 3件: 79, 218, 222 💬
25 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Pravastatin 💬 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333 💬
26 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Rosuvastatin 💬 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299 💬
27 HMOX1 💬 10件: Porphyrin metabolism, Metabolic pathways, HIF-1 signaling pathway, Ferroptosis, Mineral absorption, Pathways in cancer, MicroRNAs in cancer, Chemical carcinogenesis - reactive oxygen species, Hepatocellular carcinoma, Fluid shear stress and atherosclerosis Stannsoporfin 💬 Stannsoporfin 1件: 254 💬
28 HMOX2 💬 3件: Porphyrin metabolism, Metabolic pathways, Mineral absorption Stannsoporfin 💬 Stannsoporfin 1件: 254 💬
29 HPD 💬 5件: Ubiquinone and other terpenoid-quinone biosynthesis, Tyrosine metabolism, Phenylalanine metabolism, Metabolic pathways, Biosynthesis of cofactors Nitisinone 💬 Nitisinone 3件: 6, 164, 241 💬
30 HPRT1 💬 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Mercaptopurine 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
31 HPRT1 💬 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Mercaptopurine 💬 Mercaptopurine 4件: 65, 96, 97, 164 💬
32 HPRT1 💬 4件: Purine metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Tioguanine 💬 Tioguanine 2件: 13, 37 💬
33 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
34 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Diphenhydramine 💬 Diphenhydramine 8件: 11, 13, 49, 51, 70, 86, 222, 256 💬
35 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Loratadine 💬 Loratadine 4件: 13, 46, 89, 98 💬
36 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Olanzapine 💬 Olanzapine 2件: 2, 8 💬
37 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Promethazine 💬 Promethazine 1件: 96 💬
38 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Clemastine 💬 Clemastine 1件: 13 💬
39 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Desloratadine 💬 Desloratadine 1件: 13 💬
40 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Chlorphenamine 💬 Chlorpheniramine 1件: 14 💬
41 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Levocetirizine 💬 Levocetirizine 1件: 61 💬
42 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Rupatadine 💬 Rupatadine 1件: 46 💬
43 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Cetirizine 💬 Cetirizine 4件: 13, 28, 35, 300 💬
44 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Dexchlorpheniramine 💬 Dexchlorpheniramine 2件: 13, 49 💬
45 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Doxepin 💬 Doxepin 1件: 6 💬
46 HRH1 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels Fexofenadine 💬 Fexofenadine 2件: 13, 46 💬
47 HRH2 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion Cimetidine 💬 Cimetidine 2件: 2, 254 💬
48 HRH2 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion Famotidine 💬 Famotidine 6件: 6, 46, 61, 86, 98, 107 💬
49 HRH2 💬 3件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gastric acid secretion Ranitidine 💬 Ranitidine 2件: 13, 65 💬
50 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Aripiprazole 💬 Aripiprazole 2件: 6, 206 💬
51 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Buspirone 💬 Buspirone 2件: 6, 51 💬
52 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Pardoprunox 💬 Pardoprunox 1件: 6 💬
53 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Cariprazine 💬 Cariprazine 1件: 21 💬
54 HTR1A 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
55 HTR1B 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Zolmitriptan 💬 Zolmitriptan 1件: 6 💬
56 HTR1D 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Zolmitriptan 💬 Zolmitriptan 1件: 6 💬
57 HTR1D 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse, Taste transduction Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
58 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
59 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Cisapride 💬 Cisapride 1件: 13 💬
60 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Clozapine 💬 Clozapine 1件: 6 💬
61 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Risperidone 💬 Risperidone 5件: 8, 156, 179, 187, 206 💬
62 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Olanzapine 💬 Olanzapine 2件: 2, 8 💬
63 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Aripiprazole 💬 Aripiprazole 2件: 6, 206 💬
64 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Cisapride 💬 Cisapride 1件: 13 💬
65 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Iloperidone 💬 Iloperidone 1件: 6 💬
66 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
67 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Quetiapine 💬 Quetiapine 2件: 6, 13 💬
68 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Trazodone 💬 Trazodone 1件: 2 💬
69 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Nelotanserin 💬 Nelotanserin 1件: 6 💬
70 HTR2A 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Cariprazine 💬 Cariprazine 1件: 21 💬
71 HTR2B 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
72 HTR2B 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Olanzapine 💬 Olanzapine 2件: 2, 8 💬
73 HTR2B 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Iloperidone 💬 Iloperidone 1件: 6 💬
74 HTR2B 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Trazodone 💬 Trazodone 1件: 2 💬
75 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Chlorpromazine 💬 Chlorpromazine 1件: 254 💬
76 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Clozapine 💬 Clozapine 1件: 6 💬
77 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Olanzapine 💬 Olanzapine 2件: 2, 8 💬
78 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Agomelatine 💬 Agomelatine 1件: 6 💬
79 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Iloperidone 💬 Iloperidone 1件: 6 💬
80 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬
81 HTR2C 💬 5件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Serotonergic synapse, Inflammatory mediator regulation of TRP channels Trazodone 💬 Trazodone 1件: 2 💬
82 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Cisapride 💬 Cisapride 1件: 13 💬
83 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Clozapine 💬 Clozapine 1件: 6 💬
84 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Ondansetron 💬 Ondansetron 3件: 6, 97, 107 💬
85 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Cisapride 💬 Cisapride 1件: 13 💬
86 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Dolasetron 💬 Dolasetron 1件: 46 💬
87 HTR3A 💬 2件: Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
88 HTR4 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Cisapride 💬 Cisapride 1件: 13 💬
89 HTR4 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Cisapride 💬 Cisapride 1件: 13 💬
90 HTR4 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Mosapride 💬 Mosapride 1件: 96 💬
91 HTR4 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Prucalopride 💬 Prucalopride 3件: 13, 51, 96 💬
92 HTR4 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Velusetrag 💬 Velusetrag 1件: 99 💬
93 HTR6 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Serotonergic synapse Olanzapine 💬 Olanzapine 2件: 2, 8 💬
94 HDAC7 💬 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
95 HAO1 💬 4件: Glyoxylate and dicarboxylate metabolism, Metabolic pathways, Carbon metabolism, Peroxisome Lumasiran 💬 Lumasiran 1件: 234 💬
96 HDAC8 💬 4件: Cell cycle, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
97 HDAC11 💬 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
98 HDAC10 💬 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
99 HDAC3 💬 4件: Neutrophil extracellular trap formation, Thyroid hormone signaling pathway, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
100 HTR3B 💬 2件: Serotonergic synapse, Taste transduction Clozapine 💬 Clozapine 1件: 6 💬
101 HTR3B 💬 2件: Serotonergic synapse, Taste transduction Ondansetron 💬 Ondansetron 3件: 6, 97, 107 💬
102 HTR3B 💬 2件: Serotonergic synapse, Taste transduction Dolasetron 💬 Dolasetron 1件: 46 💬
103 HTR3B 💬 2件: Serotonergic synapse, Taste transduction Vortioxetine 💬 Vortioxetine 1件: 6 💬
104 HDAC9 💬 3件: Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis Vorinostat 💬 Vorinostat 2件: 75, 96 💬
105 HDAC4 💬 5件: Apelin signaling pathway, Neutrophil extracellular trap formation, Alcoholism, Viral carcinogenesis, MicroRNAs in cancer Vorinostat 💬 Vorinostat 2件: 75, 96 💬