Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
2 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
3 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
4 NCSTN 2件: Notch signaling pathway 💬, Alzheimer disease 💬 D09010 Tarenflurbil 1件: 13
5 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00088 Hydrocortisone 11件: 6, 41, 46, 53, 75, 78, 81, 83, 97, 98, 299
6 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00165 Hydrocortisone acetate 1件: 97
7 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00244 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
8 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00246 Budesonide 9件: 66, 93, 94, 95, 96, 97, 98, 228, 299
9 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00292 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
10 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00385 Triamcinolone 10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
11 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
12 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
13 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
14 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00585 Mifepristone 1件: 75
15 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00689 Beclomethasone dipropionate 3件: 85, 97, 98
16 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00690 Mometasone 2件: 98, 162
17 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00690 Mometasone furoate 2件: 98, 162
18 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
19 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00972 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
20 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00973 Cortisone acetate 1件: 81
21 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00975 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
22 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00976 Hydrocortisone cypionate 3件: 6, 81, 83
23 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
24 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
25 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone acetate 1件: 222
26 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
27 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
28 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00983 Triamcinolone 10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
29 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00984 Triamcinolone 10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
30 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00985 Triamcinolone 10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
31 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
32 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01272 Clobetasol propionate 2件: 46, 162
33 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01357 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
34 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01402 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
35 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01442 Hydrocortisone succinate 3件: 6, 81, 83
36 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01510 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
37 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01615 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
38 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01632 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
39 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01637 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
40 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01703 Ciclesonide 1件: 84
41 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01708 Fluticasone propionate 2件: 98, 228
42 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01825 Fluocinolone acetonide 1件: 90
43 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01948 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
44 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
45 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02032 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
46 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
47 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02174 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
48 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02286 Betamethasone 7件: 2, 28, 46, 83, 90, 96, 235
49 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02591 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
50 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02592 Dexamethasone 25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
51 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
52 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03325 Mometasone 2件: 98, 162
53 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03671 Deflazacort 2件: 30, 113
54 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
55 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone hemisuccinate 7件: 13, 49, 50, 51, 53, 97, 211
56 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
57 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
58 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D06216 Triamcinolone 10件: 35, 46, 56, 70, 90, 96, 107, 162, 226, 298
59 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07202 Halometasone 1件: 162
60 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07495 Beclomethasone dipropionate 3件: 85, 97, 98
61 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07715 Clobetasol propionate 2件: 46, 162
62 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07715 Clobetasol 4件: 39, 46, 51, 162
63 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07749 Cortisone 1件: 81
64 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07981 Fluticasone 3件: 98, 228, 299
65 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D08227 Mometasone 2件: 98, 162
66 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D08416 Prednisone acetate 7件: 35, 40, 41, 46, 49, 162, 224
67 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D11000 Vamorolone 2件: 97, 113
68 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D11336 Relacorilant 1件: 75
69 NPC1L1 1件: Fat digestion and absorption 💬 D01966 Ezetimibe 4件: 49, 79, 93, 260
70 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00443 Spironolactone 7件: 58, 67, 86, 113, 210, 218, 225
71 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00986 Fludrocortisone 3件: 6, 17, 81
72 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D01115 Eplerenone 4件: 75, 113, 210, 215
73 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D07967 Fludrocortisone 3件: 6, 17, 81
74 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D10528 Aldosterone 1件: 222
75 NFE2L2 7件: Protein processing in endoplasmic reticulum 💬, Parkinson disease 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D10964 Omaveloxolone 1件: 18
76 NFKB1 76件: Antifolate resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, NF-kappa B signaling pathway 💬, HIF-1 signaling pathway 💬, Sphingolipid signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Longevity regulating pathway 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, TNF signaling pathway 💬, Neurotrophin signaling pathway 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, Relaxin signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Pancreatic cancer 💬, Prostate cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Small cell lung cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬, Diabetic cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D01146 Iguratimod 4件: 46, 51, 53, 271
77 NGF 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Neurotrophin signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬 D09387 Tanezumab 2件: 226, 298
78 NGFR 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, Apoptosis - multiple species 💬, Neurotrophin signaling pathway 💬, Transcriptional misregulation in cancer 💬 D11028 Cenegermin 2件: 53, 90
79 NPR1 10件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Vascular smooth muscle contraction 💬, Thermogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬 D04051 Erythrityl tetranitrate 1件: 46
80 NPR1 10件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Vascular smooth muscle contraction 💬, Thermogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬 D05147 Nesiritide 2件: 46, 58
81 NPR2 5件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Oxytocin signaling pathway 💬 D04051 Erythrityl tetranitrate 1件: 46
82 NPR2 5件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Oxytocin signaling pathway 💬 D11190 Vosoritide 1件: 276
83 NR1H4 1件: Bile secretion 💬 D00163 Chenodeoxycholic acid 4件: 20, 96, 234, 263
84 NR1H4 1件: Bile secretion 💬 D00734 Ursodeoxycholic acid 14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299
85 NR1H4 1件: Bile secretion 💬 D09360 Obeticholic acid 3件: 93, 265, 296
86 NR1H4 1件: Bile secretion 💬 D10699 Cholic Acid 4件: 20, 234, 265, 310
87 NR1H4 1件: Bile secretion 💬 D11548 Tropifexor 1件: 93