Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 KCNA4 2件: Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
2 KCNA4 2件: Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D10228 Amifampridine 3件: 3, 11, 12
3 KCNC3 1件: Spinocerebellar ataxia 💬 D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
4 KCNC3 1件: Spinocerebellar ataxia 💬 D10228 Amifampridine 3件: 3, 11, 12
5 KCND2 1件: Serotonergic synapse 💬 D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
6 KCND2 1件: Serotonergic synapse 💬 D10228 Amifampridine 3件: 3, 11, 12
7 KCND3 1件: Spinocerebellar ataxia 💬 D00636 Amiodarone 2件: 28, 127
8 KCND3 1件: Spinocerebellar ataxia 💬 D02910 Amiodarone 2件: 28, 127
9 KCND3 1件: Spinocerebellar ataxia 💬 D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
10 KCND3 1件: Spinocerebellar ataxia 💬 D10228 Amifampridine 3件: 3, 11, 12
11 KCNJ3 10件: Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, GnRH secretion 💬, Morphine addiction 💬 D00636 Amiodarone 2件: 28, 127
12 KCNJ3 10件: Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, GnRH secretion 💬, Morphine addiction 💬 D02910 Amiodarone 2件: 28, 127
13 KCNJ5 9件: Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Aldosterone synthesis and secretion 💬, GnRH secretion 💬, Morphine addiction 💬 D00636 Amiodarone 2件: 28, 127
14 KCNJ5 9件: Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Aldosterone synthesis and secretion 💬, GnRH secretion 💬, Morphine addiction 💬 D02910 Amiodarone 2件: 28, 127
15 KCNJ8 1件: cGMP-PKG signaling pathway 💬 D00636 Amiodarone 2件: 28, 127
16 KCNJ8 1件: cGMP-PKG signaling pathway 💬 D02910 Amiodarone 2件: 28, 127
17 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D00294 Diazoxide 2件: 13, 193
18 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D00418 Minoxidil 1件: 179
19 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D00594 Repaglinide 3件: 6, 21, 299
20 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D00636 Amiodarone 2件: 28, 127
21 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D02910 Amiodarone 2件: 28, 127
22 KCNJ12 2件: Cholinergic synapse 💬, Oxytocin signaling pathway 💬 D00636 Amiodarone 2件: 28, 127
23 KCNJ12 2件: Cholinergic synapse 💬, Oxytocin signaling pathway 💬 D02910 Amiodarone 2件: 28, 127
24 KCNQ1 6件: Adrenergic signaling in cardiomyocytes 💬, Cholinergic synapse 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Protein digestion and absorption 💬, Vibrio cholerae infection 💬 D00636 Amiodarone 2件: 28, 127
25 KCNQ1 6件: Adrenergic signaling in cardiomyocytes 💬, Cholinergic synapse 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Protein digestion and absorption 💬, Vibrio cholerae infection 💬 D02910 Amiodarone 2件: 28, 127
26 KCNQ1 6件: Adrenergic signaling in cardiomyocytes 💬, Cholinergic synapse 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Protein digestion and absorption 💬, Vibrio cholerae infection 💬 D09569 Ezogabine 2件: 2, 144
27 KCNQ2 1件: Cholinergic synapse 💬 D09569 Ezogabine 2件: 2, 144
28 KCNQ3 1件: Cholinergic synapse 💬 D09569 Ezogabine 2件: 2, 144
29 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D03218 Axitinib 1件: 34
30 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D06272 Sorafenib 2件: 34, 86
31 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D06402 Sunitinib 2件: 28, 34
32 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D08524 Sorafenib 2件: 34, 86
33 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D08552 Sunitinib 2件: 28, 34
34 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D08881 Cediranib 1件: 34
35 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D10062 Cabozantinib 1件: 34
36 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
37 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D11772 Tesevatinib 1件: 67
38 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
39 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D03658 Dasatinib 2件: 51, 85
40 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D06272 Sorafenib 2件: 34, 86
41 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D06402 Sunitinib 2件: 28, 34
42 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D06414 Dasatinib 2件: 51, 85
43 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
44 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08524 Sorafenib 2件: 34, 86
45 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08552 Sunitinib 2件: 28, 34
46 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08953 Nilotinib 5件: 6, 8, 34, 51, 86
47 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D10229 Masitinib 6件: 2, 5, 6, 13, 46, 96
48 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D11270 Pexidartinib 1件: 34
49 KLKB1 1件: Complement and coagulation cascades 💬 D10845 Conestat alfa 1件: 61
50 KCNQ5 1件: Cholinergic synapse 💬 D09569 Ezogabine 2件: 2, 144
51 KCNQ4 1件: Cholinergic synapse 💬 D09569 Ezogabine 2件: 2, 144
52 KEAP1 6件: Ubiquitin mediated proteolysis 💬, Parkinson disease 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D03846 Dimethyl fumarate 5件: 13, 49, 51, 86, 296