Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 F2 8件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Regulation of actin cytoskeleton 💬, Pathogenic Escherichia coli infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D06410 Thrombomodulin Alfa 1件: 85
2 F2 8件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Regulation of actin cytoskeleton 💬, Pathogenic Escherichia coli infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D07144 Dabigatran etexilate 1件: 51
3 F2 8件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Regulation of actin cytoskeleton 💬, Pathogenic Escherichia coli infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D09707 Dabigatran 4件: 51, 85, 91, 124
4 F8 1件: Complement and coagulation cascades 💬 D00291 Desmopressin 6件: 6, 64, 72, 75, 225, 288
5 F8 1件: Complement and coagulation cascades 💬 D02235 Desmopressin 6件: 6, 64, 72, 75, 225, 288
6 F9 1件: Complement and coagulation cascades 💬 D10821 Emicizumab 1件: 288
7 F10 1件: Complement and coagulation cascades 💬 D03213 Apixaban 3件: 96, 97, 222
8 F10 1件: Complement and coagulation cascades 💬 D07086 Rivaroxaban 5件: 46, 49, 75, 91, 210
9 F10 1件: Complement and coagulation cascades 💬 D09710 Edoxaban 2件: 46, 88
10 F10 1件: Complement and coagulation cascades 💬 D10821 Emicizumab 1件: 288
11 FCER1A 4件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Asthma 💬 D05251 Omalizumab 7件: 46, 53, 65, 98, 162, 226, 299
12 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00939 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
13 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00941 Pamidronic acid 3件: 270, 271, 274
14 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00942 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
15 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D01968 Zoledronic acid 13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
16 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D03234 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
17 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D06378 Zoledronic acid 13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
18 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D06379 Zoledronic acid 13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
19 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D07119 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
20 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D07281 Pamidronic acid 3件: 270, 271, 274
21 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D08056 Ibandronate 3件: 46, 49, 274
22 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D08484 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
23 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D08689 Zoledronic acid 13件: 5, 6, 13, 17, 46, 65, 93, 95, 96, 270, 274, 299, 333
24 FGFR1 16件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Adherens junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Thermogenesis 💬, Regulation of actin cytoskeleton 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Prostate cancer 💬, Melanoma 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
25 FGFR1 16件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Adherens junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Thermogenesis 💬, Regulation of actin cytoskeleton 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Prostate cancer 💬, Melanoma 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D11589 Infigratinib 1件: 276
26 FGFR3 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Bladder cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
27 FGFR3 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Bladder cancer 💬, Central carbon metabolism in cancer 💬 D11589 Infigratinib 1件: 276
28 FGFR2 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, Prostate cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D05338 Palifermin 5件: 13, 36, 38, 39, 65
29 FGFR2 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, Prostate cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
30 FGFR2 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, Prostate cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D11589 Infigratinib 1件: 276
31 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D03218 Axitinib 1件: 34
32 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D06402 Sunitinib 2件: 28, 34
33 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D08552 Sunitinib 2件: 28, 34
34 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D08881 Cediranib 1件: 34
35 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
36 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D06272 Sorafenib 2件: 34, 86
37 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D06402 Sunitinib 2件: 28, 34
38 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D08524 Sorafenib 2件: 34, 86
39 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D08552 Sunitinib 2件: 28, 34
40 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D11270 Pexidartinib 1件: 34
41 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D03218 Axitinib 1件: 34
42 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D06272 Sorafenib 2件: 34, 86
43 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D06402 Sunitinib 2件: 28, 34
44 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D08524 Sorafenib 2件: 34, 86
45 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D08552 Sunitinib 2件: 28, 34
46 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D08881 Cediranib 1件: 34
47 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
48 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D11772 Tesevatinib 1件: 67
49 FNTA 1件: Terpenoid backbone biosynthesis 💬 D03720 Tipifarnib 1件: 34
50 FNTA 1件: Terpenoid backbone biosynthesis 💬 D04768 Lonafarnib 2件: 113, 333
51 FNTB 1件: Terpenoid backbone biosynthesis 💬 D03720 Tipifarnib 1件: 34
52 FNTB 1件: Terpenoid backbone biosynthesis 💬 D04768 Lonafarnib 2件: 113, 333
53 FYN 14件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Axon guidance 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Adherens junction 💬, Platelet activation 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Cholinergic synapse 💬, Prion disease 💬, Pathogenic Escherichia coli infection 💬, Viral myocarditis 💬 D03658 Dasatinib 2件: 51, 85
54 FYN 14件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Axon guidance 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Adherens junction 💬, Platelet activation 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Cholinergic synapse 💬, Prion disease 💬, Pathogenic Escherichia coli infection 💬, Viral myocarditis 💬 D06414 Dasatinib 2件: 51, 85
55 FGF23 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Regulation of actin cytoskeleton 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Melanoma 💬, Breast cancer 💬, Gastric cancer 💬 D10913 Burosumab 1件: 238