Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00122 Calcifediol 2件: 113, 299
2 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00129 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326
3 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00187 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299
4 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00188 Cholecalciferol 25件: 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
5 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00299 Dihydrotachysterol 2件: 6, 85
6 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00930 Paricalcitol 4件: 19, 66, 218, 238
7 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D01125 Calcipotriol 2件: 36, 51
8 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D01518 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238
9 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D07578 Eldecalcitol 1件: 46
10 VEGFA 24件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Bladder cancer 💬, Rheumatoid arthritis 💬, Fluid shear stress and atherosclerosis 💬 D05697 Ranibizumab 4件: 34, 166, 227, 301
11 VEGFA 24件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Bladder cancer 💬, Rheumatoid arthritis 💬, Fluid shear stress and atherosclerosis 💬 D06409 Bevacizumab 9件: 13, 34, 85, 86, 87, 89, 227, 280, 331
12 VEGFA 24件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Bladder cancer 💬, Rheumatoid arthritis 💬, Fluid shear stress and atherosclerosis 💬 D09574 Aflibercept 2件: 90, 166
13 VEGFB 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Relaxin signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Pathways in cancer 💬 D09574 Aflibercept 2件: 90, 166
14 VWF 8件: PI3K-Akt signaling pathway 💬, Focal adhesion 💬, ECM-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Neutrophil extracellular trap formation 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬 D11160 Caplacizumab 1件: 64
15 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
16 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
17 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D08354 Phenindione 1件: 65
18 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97