Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 DHODH 💬 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors Leflunomide 💬 Leflunomide 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300 💬
2 DHODH 💬 3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors Teriflunomide 💬 Teriflunomide 3件: 13, 25, 26 💬
3 RRM1 💬 6件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Cladribine 💬 Cladribine 3件: 11, 13, 94 💬
4 RRM1 💬 6件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Clofarabine 💬 Clofarabine 5件: 19, 20, 60, 234, 326 💬
5 RRM1 💬 6件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism Fludarabine 💬 Fludarabine 20件: 11, 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326 💬
6 RRM2 💬 7件: Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, Drug metabolism - other enzymes, Metabolic pathways, Nucleotide metabolism, p53 signaling pathway Hydroxyurea 💬 Hydroxyurea 8件: 3, 13, 19, 20, 65, 85, 86, 284 💬
7 TYMS 💬 5件: Pyrimidine metabolism, One carbon pool by folate, Metabolic pathways, Nucleotide metabolism, Antifolate resistance Tegafur 💬 Tegafur 1件: 46 💬