Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Cellular senescence 💬
1件: CACNA1D 💬 D00615 💬 Amlodipine 4件: 13, 51, 67, 298 💬
2 Cellular senescence 💬
1件: CACNA1D 💬 D02914 💬 Amlodipine 4件: 13, 51, 67, 298 💬
3 Cellular senescence 💬
1件: CACNA1D 💬 D07450 💬 Amlodipine 4件: 13, 51, 67, 298 💬
4 Cellular senescence 💬
1件: CACNA1D 💬 D01173 💬 Cilnidipine 1件: 67 💬
5 Cellular senescence 💬
1件: CACNA1D 💬 D00616 💬 Diltiazem 3件: 51, 58, 86 💬
6 Cellular senescence 💬
1件: CACNA1D 💬 D03830 💬 Diltiazem 3件: 51, 58, 86 💬
7 Cellular senescence 💬
1件: CACNA1D 💬 D07845 💬 Diltiazem 3件: 51, 58, 86 💬
8 Cellular senescence 💬
1件: CACNA1D 💬 D00349 💬 Isradipine 1件:  6  💬
9 Cellular senescence 💬
1件: CACNA1D 💬 D00617 💬 Nicardipine 2件: 70, 86 💬
10 Cellular senescence 💬
1件: CACNA1D 💬 D08270 💬 Nicardipine 2件: 70, 86 💬
11 Cellular senescence 💬
1件: CACNA1D 💬 D00437 💬 Nifedipine 2件: 50, 81 💬
12 Cellular senescence 💬
1件: CACNA1D 💬 D01908 💬 Nilvadipine 1件: 90 💬
13 Cellular senescence 💬
1件: CACNA1D 💬 D05442 💬 Perhexiline 2件: 58, 272 💬
14 Cellular senescence 💬
1件: CACNA1D 💬 D08340 💬 Perhexiline 2件: 58, 272 💬
15 Cellular senescence 💬
1件: CACNA1D 💬 D08441 💬 Propiverine 1件: 226 💬
16 Cellular senescence 💬
1件: CACNA1D 💬 D00537 💬 Topiramate 6件:  6 , 97, 140, 144, 156, 193 💬
17 Cellular senescence 💬
1件: CACNA1D 💬 D00619 💬 Verapamil 3件: 96, 140, 167 💬
18 Cellular senescence 💬
1件: CACNA1D 💬 D02356 💬 Verapamil 3件: 96, 140, 167 💬
19 Cellular senescence 💬
2件: CDK4, CDK6 💬 D10688 💬 Abemaciclib 1件: 34 💬
20 Cellular senescence 💬
6件: HLA-A, HLA-B, HLA-C, HLA-E, HLA-F, HLA-G 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
21 Cellular senescence 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
22 Cellular senescence 💬
1件: IL1A 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
23 Cellular senescence 💬
2件: IL1A, IL6 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
24 Cellular senescence 💬
1件: IL6 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
25 Cellular senescence 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
26 Cellular senescence 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
27 Cellular senescence 💬
2件: MAP2K1, MAP2K2 💬 D10604 💬 Binimetinib 1件: 34 💬
28 Cellular senescence 💬
2件: MAP2K1, MAP2K2 💬 D10405 💬 Cobimetinib 1件: 280 💬
29 Cellular senescence 💬
2件: MAP2K1, MAP2K2 💬 D09666 💬 Selumetinib 1件: 34 💬
30 Cellular senescence 💬
2件: MAP2K1, MAP2K2 💬 D10175 💬 Trametinib 4件:  2 , 34, 279, 280 💬
31 Cellular senescence 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
32 Cellular senescence 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
33 Cellular senescence 💬
1件: MTOR 💬 D02714 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬
34 Cellular senescence 💬
1件: MTOR 💬 D00753 💬 Sirolimus 41件:  2 ,  6 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331 💬
35 Cellular senescence 💬
1件: MTOR 💬 D06068 💬 Temsirolimus 4件: 13, 34, 89, 331 💬
36 Cellular senescence 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
37 Cellular senescence 💬
3件: PIK3CA, PIK3CB, PIK3CD 💬 D11158 💬 Leniolisib 2件: 53, 65 💬
38 Cellular senescence 💬
1件: PIK3CD 💬 D11437 💬 Parsaclisib 3件: 35, 53, 61 💬
39 Cellular senescence 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
40 Cellular senescence 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
41 Cellular senescence 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
42 Cellular senescence 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
43 Cellular senescence 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
44 Cellular senescence 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
45 Cellular senescence 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
46 Cellular senescence 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
47 Cellular senescence 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬